Staff Profile

1998 Specialist in Biology-Biophysics (BSc), Taras Shevchenko Kiev State University

2003 Doctor of Biological Sciences (PhD) in Biophysics, Bogomoletz Institute of Physiology

2016 Fellow of Higher Education Academy, Cardiff University

Employment records

2017 Lecturer in Physiology, School of Dental Sciences, Newcastle University

2012 Senior Research Fellow, School of Biosciences, Cardiff University

2009 Research Associate, Research Department of Neuroscience, Physiology and Pharmacology, University College London

2007 Research Associate in the School of Biosciences, Cardiff University

2006 Research Associate, Department of Pharmacy and Pharmacology, University of Bath

2004 Research Associate, Department of Obstetrics and Gynaecology, College of Medicine, University of Vermont

Awards

2019 Long Term Invitational Fellowship - Japan Society for the Promotion of Science (JSPS)

2021 Chinese Academy of Sciences International Fellowship Initiative (CAS PIFI)

Memberships

Regular Member of European Huntington’s Disease Network (EHDN)

Member of The Physiological Society (established physiologist)

Regular Member of Biophysical Society

Additional Affiliations

Visitor at University College London and Cardiff University

Membership in editorial boards

Antioxidants & Redox Signaling Journal

Cardiovascular Research

Oxidative Medicine and Cellular Longevity

Roles and responsibilities

Dental Physiology Course Leader

Dental Physiology Course Leader

BDS1. Cellular Physiology

BDS1. Cardiovascular System

BDS1. Gastrointestinal Tract and Renal Physiology

BDS1. Orientation and Study Skills

BDS1. Neurobiology

Research Interests

The studies of our group is focused on physiological/pathophysiological aspects of neuronal differentiation, maturation and degeneration in relation to the persistent neuropathic and acute pain of various aetiology. In our research we employ in vitro pain models on recombinant cell lines, primarily cultured sensory neurons isolated from animals (rats and mice) and the neurons derived from human induced pluripotent stem cells (hiPSCs). Using these models we explore the pathways of ion channel regulation by G-protein coupled receptors (GPCRs) with a set of physiological and molecular techniques.

The aim of our research is to generate the data that provide rational basis for selecting drugs which may be useful for enhancing neuronal function in patients with neurodegenerative disorders, inflammatory, post traumatic and neuropathic pain.

• Yarova PL, Huang P, Schepelmann MW, Bruce R, Ecker R, Nica R, Telezhkin V, Traini D, dos Reis LG, Kidd EJ, Ford WR, Broadley KJ, Kariuki BM, Corrigan CJ, Ward JPT, Kemp PJ, Riccardi D. Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma. Journal of Pharmacology and Experimental Therapeutics 2021, 376(1), 51-63.
• Chuinsiri N, Edwards D, Telezhkin V, Nile CJ, Van der Cruyssen F, Durham J. Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies. Archives of Oral Biology 2021, 130, 105247.
• Kukharsky MS, Ninkina NN, An H, Telezhkin V, Wei W, Meritens CR, Cooper-Knock J, Nakagawa S, Hirose T, Buchman VL, Shelkovnikova TA. Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice. Translational Psychiatry 2020, 10(1), 171.
• Obara I, Telezhkin V, Alrashdi I, Chazot PL. Histamine, histamine receptors, and neuropathic pain relief. British Journal of Pharmacology 2019, 177(3), 580-599.
• Telezhkin V, Straccia M, Yarova P, Pardo M, Yung S, Vinh N-N, Hancock JM, Barriga GG-D, Brown DA, Rosser AE, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflugers Archiv European Journal of Physiology 2018, 470, 1359-1376.
• Young F, Telezhkin V, Youde SJ, Langley MS, Stack M, Kemp PJ, Waddington RJ, Sloan AJ, Song B. Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells. Stem Cells International 2016, 2016, 1290561.
• Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, Joy S, Badder L, Connor-Robson N, Comella A, Straccia M, Bombau G, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ. Forced cell cycle exit and modulation of GABA_A, CREB, and GSK₃β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology 2016, 310(7), C520-C541.
• Brazier SP, Telezhkin V, Kemp PJ. Functional Interactions between BK_Ca^α-Subunit and Annexin A5: Implications in Apoptosis. Oxidative Medicine and Cellular Longevity 2016, 2016, 1607092.
• Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, Riccardi D, Randall AD, Brown JT, Allen ND, Telezhkin V. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 2016, 594(22), 6583-6594.
• Zhang G, Edmundson M, Telezhkin V, Gu Y, Wei X, Kemp PJ, Song B. The Role of Kv1.2 Channel in Electrotaxis Cell Migration. Journal of Cellular Physiology 2016, 231(6), 1375–1384.
• Hänggi P, Telezhkin V, Kemp PJ, Schmugge M, Gassmann M, Goede JS, Speer O, Bogdanova A. Functional plasticity of the N-methyl-D-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology: Cell Physiology 2015, 308(12), C993–C1007.
• Kemp PJ, Telezhkin V. Oxygen sensing by the carotid body: is it all just rotten eggs?. Antioxidants & Redox Signaling 2014, 20(5), 794-804.
• Telezhkin V, Thomas AM, Harmer SC, Tinker A, Brown DA. A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂. Pflügers Archiv - European Journal of Physiology 2013, 465(7), 945-953.
• Reilly JM, Telezhkin V, Passmore GM, Marsh SJ, Brown DA. Kv7/M-type potassium channels in rat skin keratinocytes. Pflügers Archiv - European Journal of Physiology 2013, 465(9), 1371-1381.
• Telezhkin V, Brown DA, Gibb AJ. Distinct subunit contributions to the activation of M-type potassium channels by PI(4,5)P₂. The Journal of General Physiology 2012, 140(1), 41-53.
• Telezhkin V, Reilly JM, Thomas AM, Tinker A, Brown DA. Structural requirements of membrane phospholipids for M-type potassium channel activation and binding. The Journal of Biological Chemistry 2012, 287(13), 10001-10012.
• Telezhkin V, Brazier SP, Mears R, Müller CT, Riccardi D, Kemp PJ. Cysteine residue 911 in C-terminal tail of human BK_Caα channel subunit is crucial for its activation by carbon monoxide. Pflügers Archiv - European Journal of Physiology 2011, 461(6), 665-675.
• Telezhkin V, Brazier SP, Cayzac S, Wilkinson WJ, Riccardi D, Kemp PJ. Mechanism of inhibition by hydrogen sulfide of native and recombinant BK_Ca channels. Respiratory Physiology & Neurobiology 2010, 172(3), 169-178.
• Brazier SP, Telezhkin V, Mears R, Müller CT, Riccardi D, Kemp PJ. Cysteine residues in the C-terminal tail of the human BK_Caα subunit are important for channel sensitivity to carbon monoxide. Advances in Experimental Medicine and Biology 2009, 648, 49-56.
• Kemp PJ, Telezhkin V, Wilkinson WJ, Mears R, Hanmer SB, Gadenberg HC, Müller CT, Riccardi D, Brazier SP. Enzyme-linked oxygen sensing by potassium channels. Annals of the New York Academy of Sciences 2009, 1177, 112–118.
• Telezhkin V, Brazier SP, Cayzac S, Muller CT, Riccardi D, Kemp PJ. Hydrogen sulfide inhibits human BK_Caα channels. Advances in Experimental Medicine and Biology 2009, 648, 65-72.
• Williams SE, Brazier SP, Baban N, Telezhkin V, Müller CT, Riccardi D, Kemp PJ. A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BK_Ca channels. Pflügers Archiv - European Journal of Physiology 2008, 456(3), 561-572.
• Telezhkin V, Goecks T, Bonev A, Osol G, Gokina NI. Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy. American Journal of Physiology - Heart and Circulatory Physiology 2008, 294(1), H272-H284.