Introduction:

I am a MRC Senior Clinical Fellow based in the Translational and Clinical Research Institute, with research interests spanning haematology and immunology. I also practice as an honorary consultant haematologist at Freeman Hospital, specialising in bone marrow transplantation, with a particular interest in adult primary inborn errors of immunity (IEI).

Research: As one of two Principle Investigators in the Haematopoiesis and Immunogenomics Laboratory, I lead a small group working to map the cellular pathways and genetic control of myeloid cell haematopoiesis, the genetic causes of dendritic cell (DC) primary immunodeficiency and the immunological consequences of these disorders. The group has also pioneered methods to probe the phenotype and function of human monocytes and DCs in clinical samples.

Clinical Practice: This immunological approach to haematology is reflected in my clinical practice, leading the bone marrow transplant service for adults with inborn errors of immunity in Newcastle upon Tyne. As one of two National Centres, we work in close collaboration with Newcastle paediatric immunology at the Great North Children's Hospital, Great Ormond Street Hospital and The Royal Free Hospital, London.

Funding has recently been agreed by NHS England to provide bone marrow transplantation for those adult patients with IEI who would benefit from the procedure.

NanoString Facility: I lead the Newcastle NanoString facility and welcome enquiries about this gene expression technology.

Qualifications:

BA (Natural Sciences), Cambridge University

BM, BChir, Cambridge University

MRCP, Royal College of Physicians (UK)

FRCPath, Royal College of Pathologists (UK)

Ph.D., Newcastle University

Membership of Learned Societies:

European Society for Immunodeficiencies

British Society of Immunology

British Society of Blood and Marrow Transplantation

British Society of Haematology

Esteem Indicators:

Editorial Board Membership:

Frontiers in Immunology

Professional responsibilities:

Reviewer for Science, Nature Immunology, Blood, Nature Reviews Immunology, Journal of Clinical Immunology, Journal of Immunology, Molecular Immunology, Cellular Immunology

Expert reviewer for MRC Infection and Immunity Board

Frontiers in Immunology Editorial Board Member

Member of Genomics England Clinical Interpretation Partnership (GeCIP)

Member of Working Party for NHS England Policy Proposal ‘All ages bone marrow transplantation for primary immunodeficiencies’

Member of the National adult primary immunodeficiency bone marrow transplant multidisciplinary team

Newcastle University Athena Swan Self Assessment Team member

Selected Lectures at Recent National and International Meetings:

European Bone Marrow Transplant Annual Meeting (EBMT2020), Virtual (2020)

UK Primary immunodeficiency Network Annual Meeting, Liverpool, UK (2019)

Paediatric Immunodeficiency Annual Meeting, London, UK (2019)

BSHI Annual meeting, Leeds (2019)

Dean's Celebratory Lecture, Newcastle University (2018)

15th International Symposium on Dendritic Cells, Aachen, Germany (2018)

28th Nikolas Symposium, Athens, Greece (2018)

Keystone Myeloid Cells, Brechenridge, USA (2018)

Northern Immunology and Allergy Meeting, Newcastle (2018)

European Society of Immunodeficiencies Annual Meeting, Edinburgh (2017)

Clinical Immunology Society (USA) Annual Meeting, Seattle, USA (2017)

Infections, Immunity, Inflammation Seminar Series, UCL, GOS Institute of Child Health, London UK (2017)

Peter Gorer Department of Immunobiology Seminar, King's College London (2016)

European Haematology Association 21st Congress, Copenhagen, Denmark (2016)

UK Primary Immunodeficiency Network, Belfast (2015)

Research Interests:

1. Dendritic Cell Haematopoiesis. 

Dendritic Cells are professional antigen presenting cells which initiate and control immune responses. They act as innate effector cells, able to recognise and respond to danger signals and influence the innate immune response. However, they are best know for their role in antigen-specific priming and activation of naive T cells to drive adaptive immune responses. On the other hand, in the absence of danger signals, DCs critically maintain tolerance to non-pathogenic and self antigen. Despite the pivotal role these cells play in infection, cancer biology, vaccine medicine and autoimmunity, the cellular pathways of their development, and the genes which control their differentiation were unknown in human. Through in vitro culture of prospective progenitors, single cell transcriptomics and the study of patients with DC deficiencies, the group has mapped the pathways and defined genes important in DC development and function, including GATA2, IRF8 and IKZF1.

2. Dendritic Cell Immunodeficiency

During my PhD work we identified an immunodeficiency syndrome associated with heterozygous GATA2 mutation, encompassing dendritic cell, monocyte and lymphoid (DCML) deficiency. We successfully treated the index case with bone marrow transplantation. In collaboration with Sophie Hambleton, we defined the clinical and cellular characteristics of a patient with bi-allelic IRF8 mutations leading to complete loss of dendritic cells and monocytes. More recently, in collaboration with Sinisia Savic and Gina Doody in Leeds, we further refined the complex immunological phenotype of bi-allelic IRF8 mutations through the study of a patient with compound heterozygous mutations. A recent international collaboration allowed us to dissect the role of IKZF1 in human DC development, based on analysis of a cohort of patients with IKZF1 haploinsufficiency and myeloma patients with pharmacological IKZF1 deficiency induced by lenalidomide treatment. These studies have highlighted the importance of DCs in human health and disease and opened avenues for therapeutic manipulation.

3. Dendritic Cell Therapy

Despite the therapeutic potential of DCs, the application of monocyte-derived DCs as vaccines has proven underwhelming. One reason for this may be that these in vitro generated cells do not sufficiently resemble in vivo DCs which develop through independent haematopoietic pathways and share their specialised roles between subsets. One prime therapeutic candidate subset, cDC1, specialised for antigen cross-presentation and critical for immune responses to tumour, virus and intracellular pathogens, is very rare in human blood. We have developed a culture system to derive clinically-relevant numbers of cDC1 from primary progenitors, leading the way for further studies to develop their translational potential.

Future work will investigate the molecular mechanisms of genes important in human DC haematopoiesis, the role of these genes in health and disease and explore options for therapeutic manipulation of in vivo cells or in vitro-generated DCs for therapy.

Future work will investigate the molecular mechanisms of genes important in human DC haematopoiesis, the role of these genes in health and disease and explore options for therapeutic manipulation of in vivo cells or in vitro-generated DCs for therapy.

Grant Funding:

MRC Senior Clinical Fellowship, 2022-2027

Newcastle Joint Research Executive Scientific Committee award, 2019

Wellcome Intermediate Clinical Fellowship, 2013-2019

Bright Red PhD Fellowship 2014-2016

Newcastle Joint Research Executive Scientific Committee award, 2014

George Walker Fellowship 2011-2013

British Society of Haematology Start up Award 2011-2013

MRC Clinical Training Fellowship 2009-2011

Tyneside Leukaemia Research Association 2008

Newcastle Healthcare Charity 2008

Undergraduate Teaching:

Medical Sciences BSc project supervisor

Postgradulate Teaching

Medical Sciences MRes and MSc project supervisor

PhD students:

3 students completed

1 current student

The lab welcomes clinicians and scientists keen to pursue doctoral and post-doctoral studies in human immunology, haematopoiesis or cellular therapy. 

• Gothe F, Hatton CF, Truong L, Klimova Z, Kanderova V, Fejtkova M, Grainger A, Bigley V, Perthen J, Mitra D, Janda A, Fronkova E, Maravicikova D, Hambleton S, Duncan CJA. A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis. Clinical Infectious Diseases 2022, 74(1), 136-139.
• Albert MH, Sirait T, Eikema DJ, Bakunina K, Wehr C, Suarez F, Fox ML, Mahlaoui N, Gennery AR, Lankester AJ, Beier R, Bernardo ME, Bigley V, Lindemans CA, OBurns S, Carpenter B, Dybko J, Gungor T, Hauck F, Lum SH, Balashov D, Meisel R, Moshous D, Schulz A, Speckmann C, Slatter MA, Strahm B, Uckan-Cetinkaya D, Meyts I, Vallee TC, Wynn R, Neven B, Morris EC, EBMT IEWP, ESID. Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study. Blood 2022, 140(14), 1635-1649.
• Cox F, Bigley V, Irvine A, Leahy R, Conlon N. PAMI Syndrome: Two Cases of an Autoinflammatory Disease with an ALPS-Like Phenotype. Journal of Clinical Immunology 2022, 42, 955–958.
• Singh P, Heer M, Resteu A, Mikulasova A, Reza M, Largeaud L, Dufrechou S, Prade N, Dickinson RE, Bustamante J, Neven B, Bigley V, Delabesse E, Rico D, Pasquet M, Collin M. GATA2 deficiency phenotype associated with tandem duplication of GATA2 and overexpression of GATA2-AS1. Blood Advances 2021, 5(24), 5631-5635.
• Collin M, Bigley V. Many Langerhans make light work of skin immunity. Immunity 2021, 54(10), 2188-2190.
• Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, McDonald D, Hulme G, Filby A, Carpenter B, Queen R, Hambleton S, Hague R, Lango Allen H, Thaventhiran JED, Doody G, Collin M, Bigley V. Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans. Immunity 2020, 53(2), 353-370.
• Jardine L, Cytlak U, Gunawan M, Reynolds G, Green K, Wang XN, Pagan S, Paramitha M, Lamb CA, Long A, Hurst E, Nair S, Jackson GH, Publicover A, Bigley V, Haniffa M, Simpson AJ, Collin M. Donor monocyte-derived macrophages promote human acute graft-versus-host disease. The Journal of Clinical Investigation 2020, 130(9), 4574-4586.
• Bigley V, Collin M. Insights from Patients with Dendritic Cell Immunodeficiency. Molecular Immunology 2020, 122, 116-123.
• Heger L, Hofer TP, Bigley V, de Vries IJM, Dalod M, Dudziak D, Ziegler-Heitbrock L. Subsets of CD1c⁺ DCs: Dendritic Cell Versus Monocyte Lineage. Frontiers in Immunology 2020, 11, 559166.
• Günther P, Cirovic B, Bassler K, Händler K, Becker M, Dutertre CA, Bigley V, Newell E, Collin M, Ginhoux F, Schlitzer A, Schultze JL. A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space. Biology 2019. In Press.
• Bigley V, Cytlak U, Collin M. Human dendritic cell immunodeficiencies. Seminars in Cell & Developmental Biology 2019, 86, 50-61.
• Milne P, Wilhelm-Benartzi C, Grunwald MR, Bigley V, Dillon R, Freeman SD, Gallagher K, Publicover A, Pagan S, Marr H, Jones GL, Dickinson AM, Grech A, Burnett AK, Russell NH, Levis M, Knapper S, Collin M. Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia. Blood Advances 2019, 3(20), 3052-3061.
• Tholouli E, Sturgess K, Dickinson RE, Gennery A, Cant AJ, Jackson G, Lordan J, Hambleton S, Slatter MA, Bigley V, Collin M. In vivo T-depleted reduced intensity transplantation for GATA2-related immune dysfunction. Blood 2018, 131(12), 1383-1387.
• Bogaert DJ, Kuehn HS, Bonroy C, Calvo KR, Dehoorne J, Vanlander AV, De Bruyne M, Cytlak U, Bigley V, De Baets F, De Baere E, Rosenzweig SD, Haerynck F, Dullaers M. A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects. Journal of Allergy and Clinical Immunology 2018, 141(1), 432-435.e7.
• Bigley V, Maisuria S, Cytlak U, Jardine L, Care MA, Green K, Gunawan M, Milne P, Dickinson R, Wiscombe S, Parry D, Doffinger R, Laurence A, Fonseca C, Stoevesandt O, Gennery A, Cant A, Tooze R, Simpson AJ, Hambleton S, Savic S, Doody G, Collin M. Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation. Journal of Allergy and Clinical Immunology 2018, 141(6), 2234-2248.
• Collin M, Bigley V. Human dendritic cell subsets: an update. Immunology 2018, 154(1), 3-20.
• Cytlak U, Resteu A, Bogaert D, Kuehn HS, Altmann T, Gennery A, Jackson G, Kumanovics A, Voelkerding KV, Prader S, Dullaers M, Reichenbach J, Hill H, Haerynck F, Rosenzweig SD, Collin M, Bigley V. Ikaros family zinc finger 1 regulates dendritic cell development and function in humans. Nature Communications 2018, 9, 1239.
• Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B. Notch signaling facilitates in vitro generation of cross-presenting classical dendritic cells. Cell Reports 2018, 23(12), 3658-3672.e6.
• Fox TA, Chakraverty R, Burns S, Carpenter B, Thomson K, Lowe D, Fielding A, Peggs K, Kottaridis P, Uttenthal B, Bigley V, Buckland M, Grandage V, Denovan S, Grace S, Dahlstrom J, Workman S, Symes A, Mackinnon S, Hough R, Morris E. Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency. Blood 2018, 131, 917-931.
• Schlums H, Jung M, Han H, Theorell J, Bigley V, Chiang SCC, Allan DSJ, Davidson-Moncada JK, Dickinson RE, Holmes TD, Hsu AP, Townsley D, Winkler T, Wang W, Aukrust P, Nordøy I, Calvo KR, Holland SM, Collin M, Dunbar CE, Bryceson YT. Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. Blood 2017, 129(14), 1927-1939.
• Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Akdemir ZC, Smith JB, Hernandez-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS. Biallelic mutations in IRF8 impair human NK cell maturation and function. Journal of Clinical Investigation 2017, 127(1), 306-320.
• Milne P, Bigley V, Bacon CM, Néel A, McGovern N, Bomken S, Haniffa M, Diamond EL, Durham BH, Visser J, Hunt D, Gunawardena H, Macheta M, McClain KL, Allen C, Abdel-Wahab O, Collin M. Hematopoietic origin of Langerhans cell histiocytosis and Erdheim Chester disease in adults. Blood 2017, 130(2), 167-175.
• McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Hong DK, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 2017, 546, 662-666.
• Green K, Pearce K, Sellar RS, Jardine L, Nicolson PL, Nagra S, Bigley V, Jackson G, Dickinson AM, Thomson K, Mackinnon S, Craddock C, Peggs KS, Collin M. Impact of Alemtuzumab Scheduling on Graft-versus-Host Disease after Unrelated Donor Fludarabine and Melphalan Allografts. Biology of Blood and Marrow Transplantation 2017, 23(5), 805-812.
• Hunt D, Milne P, Fernandes P, Bigley V, Collin M. Targeted treatment of brainstem neurohistiocytosis guided by urinary cell-free DNA. Neurology: Neuroimmunology & Neuroinflammation 2017, 4(1), e299.
• Patel AA, Zhang Y, Fullerton JN, Boelen L, Rongvaux A, Maini AA, Bigley V, Flavell RA, Gilroy DW, Asquith B, Macallan D, Yona S. The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. Journal of Experimental Medicine 2017, 214(7), 1913-1923.
• Bigley V, Barge D, Collin M. Dendritic cell analysis in primary immunodeficiency. Current Opinion in Allergy & Clinical Immunology 2016, 16(6), 530-540.
• Hardie C, Green K, Jopson L, Millar B, Innes B, Pagan S, Tiniakos D, Dyson J, Haniffa M, Bigley V, Jones DE, Brain J, Walker LJ. Early Molecular Stratification of High-risk Primary Biliary Cholangitis. EBioMedicine 2016, 14, 65-73.
• Collin M, Bigley V. Monocyte, macrophage, and dendritic cell development: The human perspective. Microbiology Spectrum 2016, 4(5).
• Webb G, Chen YY, Li KK, Neil D, Oo YH, Richter A, Bigley V, Collin M, Adams DH, Hirschfield GM. Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease. Journal of Hepatology 2016, 64(5), 1190-1193.
• Mannurita SC, Vignoli M, Colarusso G, Tucci F, Veltroni M, Frenos S, Tintori V, Arico M, Bigley V, Collin M, Favre C, Gambineri E. Timely follow-up of a GATA2 deficiency patient allows successful treatment. Journal of Allergy and Clinical Immunology 2016, 138(5), 1480-1483.
• Jardine L, Publicover A, Bigley V, Hale G, Pearce K, Dickinson A, Jackson G, Collin M. A comparative study of reduced dose alemtuzumab in matched unrelated donor and related donor reduced intensity transplants. British Journal of Haematology 2015, 168(6), 874-881.
• Salotti J, Collin M, Wood K, Bigley V, Windebank K. A survey of adults with histiocytic disorders in Northeast England. 2015. In Preparation.
• Milne P, Bigley V, Gunawan M, Haniffa M, Collin M. CD1c⁺ blood dendritic cells have Langerhans cell potential. Blood 2015, 125(3), 470-473.
• Collin M, Bigley V, McClain KL, Allen CE. Cell(s) of Origin of Langerhans Cell Histiocytosis. Hematology/Oncology Clinics of North America 2015, 29(5), 825-838.
• Collin M, Dickinson R, Bigley V. Haematopoietic and immune defects associated with GATA2 mutation. British Journal Of Haematology 2015, 169(2), 173-187.
• Haniffa M, Bigley V, Collin M. Human mononuclear phagocyte system reunited. Seminars in Cell & Developmental Biology 2015, 41, 59-69.
• Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, Haniffa M, Collin M. Langerin-expressing dendritic cells in human tissues are related to CD1c⁺ dendritic cells and distinct from Langerhans cells and CD₁₄₁^high XCR1⁺ dendritic cells. Journal of Leukocyte Biology 2015, 97(4), 627-634.
• Holzinger D, Fassl SK, de Jager W, Lohse P, Rohrig UF, Gattorno M, Omenetti A, Chiesa S, Schena F, Austermann J, Vogl T, Kuhns DB, Holland SM, Rodriguez-Gallego C, Lopez-Almaraz R, Arostegui JI, Colino E, Roldan R, Fessatou S, Isidor B, Poignant S, Ito K, Epple HJ, Bernstein JA, Jeng M, Frankovich J, Lionetti G, Church JA, Ong PY, LaPlant M, Abinun M, Skinner R, Bigley V, Sachs UJ, Hinze C, Hoppenreijs E, Ehrchen J, Foell D, Chae JJ, Ombrello A, Aksentijevich I, Sunderkoetter C, Roth J. Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. Journal of Allergy and Clinical Immunology 2015, 136(5), 1337-1345.
• Berres ML, Lim KPH, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrao M, Lira SA, Heym KM, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. Journal of Experimental Medicine 2014, 211(4), 669-683.
• Salem S, Langlais D, Lefebvre F, Bourque G, Bigley V, Haniffa M, Casanova JL, Burk D, Berghuis A, Butler KM, Leahy TR, Hambleton S, Gros P. Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8^K108E mutation. Blood 2014, 124(12), 1894-1904.
• McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Saavedra DM, Larbi A, Wasan PS, Duan K, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M. Human Dermal CD14⁺ Cells Are a Transient Population of Monocyte-Derived Macrophages. Immunity 2014, 41(3), 465-477.
• Sturgess K, Thoulouli E, Jackson G, Bigley V, Collin M. T cell depleted reduced intensity transplantation is effective for patients with GATA2 mutation and severe infections or respiratory compromise. In: 40th Annual Meeting of the European Group for Blood and Marrow Transplantation. 2014, Milan, Italy: Nature Publishing Group.
• Dickinson RE, Milne P, Jardine L, Zandi S, Swierczek SI, McGovern N, Cookson S, Ferozepurwalla Z, Langridge A, Pagan S, Gennery A, Heiskanen-Kosma T, Hamalainen S, Seppanen M, Helbert M, Tholouli E, Gambineri E, Reykdal S, Gottfreosson M, Thaventhiran JE, Morris E, Hirschfield G, Richter AG, Jolles S, Bacon CM, Hambleton S, Haniffa M, Bryceson Y, Allen C, Prchal JT, Dick JE, Bigley V, Collin M. The evolution of cellular deficiency in GATA2 mutation. Blood 2014, 123(6), 863-874.
• Jardine L, Barge D, Ames-Draycott A, Pagan S, Cookson S, Spickett G, Haniffa M, Collin M, Bigley V. Rapid detection of dendritic cell and monocyte disorders using CD4 as a lineage marker of the human peripheral blood antigen-presenting cell compartment. Frontiers in Immunology 2013, 4(4), 495.
• Jardine L, Hambleton S, Bigley V, Pagan S, Wang X-N, Collin M. Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands. Leukemia and Lymphoma 2013, 54(1), 167-173.
• Hugle T, O'Reilly S, Simpson R, Kraaij MD, Bigley V, Collin M, Krippner-Heidenreich A, van Laar JM. Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts. Arthritis & Rheumatism 2013, 65(2), 481-491.
• Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141^hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103⁺ Nonlymphoid Dendritic Cells. Immunity 2012, 37(1), 60-73.
• Haniffa M, Shin A, Bigley V, McGovern N, Wang X, Wasan P, Gehring A, Bertoletti A, Collin M, Ginhoux F. Identification of the human cross-presenting migratory dendritic cell and harmonization of the functional classification of human and mouse dendritic cells. In: European Congress of Immunology. 2012, Glasgow: Wiley-Blackwell.
• Hambleton S, Salem S, Bustamente J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez C, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong X, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova J-L, Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency. New England Journal of Medicine 2011, 365(2), 127-138.
• Bigley V, Collin M. Dendritic cell, monocyte, B and NK lymphoid deficiency defines the lost lineages of a new GATA-2 dependent myelodysplastic syndrome. Haematologica 2011, 96(8), 1081-1083.
• Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 2011, 118(10), 2656-2658.
• Collin M, Bigley V, Haniffa M, Hambleton S. Human dendritic cell deficiency: the missing ID?. Nature Reviews Immunology 2011, 11(9), 575-583.
• Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Dick JE, Hambleton S, Collin M. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. Journal of Experimental Medicine 2011, 208(2), 227-234.
• Haniffa M, Ginhoux F, Wang XN, Bigley V, Abel M, Dimmick I, Bullock S, Grisotto M, Booth T, Taub P, Hilkens C, Merad M, Collin M. Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. Journal of Experimental Medicine 2009, 206(2), 371-385.
• Bigley VH, Duarte RF, Gosling RD, Kibbler CC, Seaton S, Potter M. Fusarium dimerum infection in a stem cell transplant recipient treated successfully with voriconazole. BONE MARROW TRANSPLANTATION 2004, 34(9), 815-817.