Staff Profile

I am an MRC Clinician Scientist in Old Age Psychiatry. My research interests include dementia with Lewy bodies, prodromal disease, brain imaging and neuroinflammation.

• Articles

  • Pan X, Donaghy PC, Roberts G, Chouliaras L, O'Brien JT, Thomas AJ, Heslegrave AJ, Zetterberg H, McGuinness B, Passmore AP, Green BD, Kane JPM. Plasma metabolites distinguish dementia with Lewy bodies from Alzheimer’s disease: a cross-sectional metabolomic analysis. Frontiers in Aging Neuroscience 2024, 15, 1326780.
  • Firbank MJ, Collerton D, da Silva Morgan K, Schumacher J, Donaghy PC, O'Brien JT, Thomas A, Taylor JP. Functional connectivity in Lewy body disease with visual hallucinations. European Journal of Neurology 2024, 31(2), e16115.
  • Hamilton CA, Matthews FE, Attems J, Donaghy PC, Erskine D, Taylor JP, Thomas AJ. Associations between multimorbidity and neuropathology in dementia: a case for considering functional cognitive disorders, psychiatric illness, and dementia mimics. British Journal of Psychiatry 2024. In Press.
  • Hicks B, Gridley K, Dixon J, Baxter K, Birks Y, Colclough C, Karim A, Perach R, Moseley E, Russell A, Sondh H, Storey B, Tipping E, Mc Ardle R, Donaghy P, Dangoor M, Miles E, Robinson L, Rusted J, Waine H, Wheatley K, Banerjee S. Using digital technologies to facilitate social inclusion during the COVID-19 pandemic: Experiences of co-resident and non-co-resident family carers of people with dementia from DETERMIND-C19. International Journal of Geriatric Psychiatry 2023, 38(2), e5886.
  • Hamilton CA, Gallagher P, Ciafone J, Barnett N, Barker SAH, Donaghy PC, O'Brien JT, Taylor J-P, Thomas AJ. Sustained attention in mild cognitive impairment with Lewy bodies and Alzheimer's disease. Journal of the International Neuropsychological Society 2024, 30(5), 421-427.
  • Durcan R, Roberts G, Hamilton CA, Donaghy PC, Howe K, Colloby SJ, Allan LM, Firbank M, Lawley S, Petrides GS, Lloyd JJ, Taylor JP, O'Brien JT, Thomas AJ. Serial Nigrostriatal Dopaminergic Imaging in Mild Cognitive Impairment With Lewy Bodies, Alzheimer Disease, and Age-Matched Controls. Neurology 2023, 101(12), e1196-e1205.
  • Donaghy PC, Carrarini C, Ferreira D, Habich A, Aarsland D, Babiloni C, Bayram E, Kane JPM, Lewis SJG, Pilotto A, Thomas AJ, Bonanni L. Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis. Alzheimer's and Dementia 2023, 19(7), 3186-3202.
  • Wright LM, Donaghy PC, Burn DJ, Taylor JP, O'Brien JT, Yarnall AJ, Matthews FE, Firbank MJ, Thomas AJ, Lawson RA. Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study. Parkinsonism and Related Disorders 2023, 113, 105762.
  • Schumacher J, Ray NJ, Hamilton CA, Bergamino M, Donaghy PC, Firbank M, Watson R, Roberts G, Allan L, Barnett N, O'Brien JT, Thomas AJ, Taylor J-P. Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease. Alzheimer's and Dementia 2023, 19(10), 4549-4563.
  • Donaghy PC, Hamilton C, Durcan R, Lawley S, Barker S, Ciafone J, Barnett N, Olsen K, Firbank M, Roberts G, Lloyd J, Allan LM, Saha R, McKeith IG, O'Brien JT, Taylor J-P, Thomas AJ. Clinical symptoms in mild cognitive impairment with Lewy bodies: Frequency, time of onset, and discriminant ability. European Journal of Neurology 2023, 30(6), 1585-1593.
  • Donaghy PC, Firbank M, Petrides G, Lloyd J, Barnett N, Olsen K, Heslegrave A, Zetterberg H, Thomas AJ, O'Brien JT. The relationship between plasma biomarkers and amyloid PET in dementia with Lewy bodies. Parkinsonism and Related Disorders 2022, 101, 111-116.
  • Thomas AJ, Hamilton CA, Barker S, Durcan R, Lawley S, Barnett N, Firbank M, Roberts G, Allan L, O'Brien J, Taylor JP, Donaghy PC. Olfactory Impairment in Mild Cognitive Impairment with Lewy Bodies and Alzheimer’s Disease. International Psychogeriatrics 2022, 34(Special Issue 6), 585-592.
  • Donaghy PC, Ciafone J, Durcan R, Hamilton CA, Barker S, Lloyd J, Firbank M, Allan LM, O'Brien JT, Taylor JP, Thomas AJ. Mild cognitive impairment with Lewy bodies: neuropsychiatric supportive symptoms and cognitive profile. Psychological Medicine 2022, 52(6), 1147-1155.
  • Chouliaras L, Thomas A, Malpetti M, Donaghy P, Kane J, Mak E, Savulich G, Prats-Sedano MA, Heslegrave AJ, Zetterberg H, Su L, Rowe JB, O'Brien JT. Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry 2022, 93(6), 651-658.
  • Schumacher J, Ray NJ, Hamilton CA, Donaghy PC, Firbank M, Roberts G, Allan L, Durcan R, Barnett N, O'Brien JT, Taylor JP, Thomas AJ. Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer’s disease. Brain 2022, 145(5), 1173-1784.
  • Roberts G, Kane JPM, Lloyd J, Firbank M, Donaghy PC, Petrides GS, Taylor J-P, O'Brien J, Thomas AJ. Can early phase cardiac [¹²³I]mIBG images be used to diagnose Lewy body disease?. Nuclear Medicine Communications 2022, 43(7), 770-777.
  • Hamilton CA, Frith J, Donaghy PC, Barker SAH, Durcan R, Lawley S, Barnett NA, Firbank M, Roberts G, Taylor JP, Allan LM, O'Brien J, Yarnall AJ, Thomas AJ. Blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre in mild cognitive impairment with Lewy bodies. International Journal of Geriatric Psychiatry 2022, 37(5).
  • Donaghy PC, Cockell SJ, Martin-Ruiz C, Coxhead J, Kane J, Erskine D, Koss D, Taylor JP, Morris CM, O'Brien JT, Thomas AJ. Blood mRNA expression in Alzheimer’s disease and dementia with Lewy bodies. American Journal of Geriatric Psychiatry 2022, 30(9), 964-975.
  • Hamilton CA, Frith J, Donaghy PC, Barker SAH, Durcan R, Lawley S, Barnett NA, Firbank M, Roberts G, Taylor JP, Allan LM, O'Brien JT, Yarnall AJ, Thomas AJ. Assessment of autonomic symptoms may assist with early identification of mild cognitive impairment with Lewy bodies. International Journal of Geriatric Psychiatry 2022, 37(4).
  • Thomas AJ, Hamilton CA, Heslegrave A, Barker S, Durcan R, Lawley S, Barnett NA, Lett D, Firbank M, Roberts G, Taylor JP, Donaghy PC, Zetterberg H, O'Brien JT. A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease. Movement Disorders 2022, 37(7), 1495-1504.
  • Hamilton CA, Matthews FE, Allan LM, Barker S, Ciafone J, Donaghy PC, Durcan R, Firbank MJ, Lawley S, O'Brien JT, Roberts G, Taylor JP, Thomas AJ. Utility of the pareidolia test in mild cognitive impairment with Lewy bodies and Alzheimer’s disease. International Journal of Geriatric Psychiatry 2021, 36(9), 1407-1414.
  • Prats-Sedano MA, Savulich G, Surendranathan A, Donaghy PC, Thomas AJ, Rowe JB, Su L, O'Brien JT. The revised Addenbrooke's Cognitive Examination can facilitate differentiation of dementia with Lewy bodies from Alzheimer's disease. International Journal of Geriatric Psychiatry 2021, 36(6), 831-838.
  • Mc Ardle R, Del Din S, Donaghy P, Galna B, Thomas A, Rochester L. The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes. Sensors 2021, 21(3), 813.
  • Hamilton C, Schumacher J, Matthews FE, Taylor JP, Allan L, Barnett N, Cromarty R, Donaghy P, Durcan R, Firbank M, Lawley S, O'Brien JT, Roberts G, Thomas A. Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment. International Psychogeriatrics 2021, 33(Special Issue 12), 1321-1325.
  • Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O'Brien JT, Barnett NA, Olsen K, Durcan R, Roberts G, Ciafone J, Barker S, Firbank MJ, McKeith IG, Thomas AJ. Progression to dementia in mild cognitive impairment with Lewy bodies or Alzheimer’s disease. Neurology 2021, 96(22), e2685-e2693.
  • Ciafone J, Thomas A, Durcan R, Donaghy P, Hamilton CA, Lawley S, Roberts G, Colloby S, Firbank MJ, Allan L, Petrides G, Taylor JP, O'Brien JT, Gallagher P. Neuropsychological Impairments and Their Cognitive Architecture in Mild Cognitive Impairment (MCI) with Lewy Bodies and MCI-Alzheimer’s Disease. Journal of the International Neuropsychological Society 2021, 28(9), 963-973.
  • Firbank MJ, O'Brien JT, Durcan R, Allan LM, Barker S, Ciafone J, Donaghy PC, Hamilton CA, Lawley S, Lloyd J, Roberts G, Taylor J-P, Thomas AJ. Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling. Journal of Neurology 2021, 268, 1284-1294.
  • Schumacher J, Taylor J-P, Hamilton CA, Firbank M, Cromarty RA, Donaghy PC, Roberts G, Allan L, Lloyd J, Durcan R, Barnett N, O'Brien JT, Thomas AJ. In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies. NeuroImage: Clinical 2021, 30, 102604.
  • Firbank MJ, Durcan R, O'Brien JT, Allan LM, Barker S, Ciafone J, Donaghy PC, Hamilton CA, Lawley S, Roberts G, Taylor JP, Thomas AJ. Hippocampal and insula volume in mild cognitive impairment with Lewy bodies. Parkinsonism and Related Disorders 2021, 86, 27-33.
  • Schumacher J, Taylor J-P, Hamilton CA, Firbank M, Donaghy PC, Roberts G, Allan L, Durcan R, Barnett N, O'Brien JT, Thomas AJ. Functional connectivity in mild cognitive impairment with Lewy bodies. Journal of Neurology 2021, 268, 4707-4720.
  • Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, Lloyd J, Petrides G, McKeith IG, Thomas AJ. Cognitive decline in mild cognitive impairment with Lewy bodies or Alzheimer’s disease: a prospective cohort study. American Journal of Geriatric Psychiatry 2021, 29(3), 272-284.
  • Roberts G, Donaghy PC, Lloyd J, Durcan R, Petrides G, Colloby SJ, Lawley S, Ciafone J, Hamilton CA, Firbank M, Allan L, Barnett N, Barker S, Olsen K, Howe K, Ali T, Taylor JP, O'Brien J, Thomas AJ. Accuracy of dopaminergic imaging as a biomarker for mild cognitive impairment with Lewy bodies. The British Journal of Psychiatry 2021, 218(5), 276-282.
  • Roberts G, Durcan R, Donaghy PC, Lawley S, Ciafone J, Hamilton CA, Colloby SJ, Firbank MJ, Allan L, Barnett N, Barker S, Howe K, Ali T, Petrides GS, Lloyd J, Taylor J-P, O'Brien J, Thomas AJ. Accuracy of Cardiac Innervation Scintigraphy for Mild Cognitive Impairment With Lewy Bodies. Neurology 2021, 96(23), e2801-e2811.
  • Revie L, Hamilton CA, Ciafone J, Donaghy PC, Thomas AJ, Metzler-Baddeley C. Visuo-Perceptual and Decision-Making Contributions to Visual Hallucinations in Mild Cognitive Impairment in Lewy Body Disease: Insights from a Drift Diffusion Analysis. Brain Sciences 2020, 10(8), 540.
  • McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz J, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P. Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology 2020, 94(17), 743-755.
  • Schumacher J, Taylor J-P, Hamilton CA, Firbank M, Cromarty RA, Donaghy PC, Roberts G, Allan L, Lloyd J, Durcan R, Barnett N, O'Brien JT, Thomas AJ. Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies. Alzheimer's Research & Therapy 2020, 12(1), 82.
  • Hamilton CA, Matthews FE, Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, McKeith IG, Thomas AJ. Prospective predictors of decline versus stability in mild cognitive impairment with Lewy bodies or Alzheimer’s disease. Psychological Medicine 2020, 51(15), 2590-2598.
  • Thomas AJ, Hamilton CA, Donaghy PC, Martin-Ruiz C, Morris CM, Barnett N, Olsen K, Taylor JP, O'Brien JT. Prospective Longitudinal Evaluation of Cytokines in mild cognitive impairment due to AD and Lewy Body Disease. International Journal of Geriatric Psychiatry 2020, 35(10), 1250-1259.
  • Durcan R, Donaghy PC, Barnett NA, Olsen K, Yarnall AJ, Taylor J-P, McKeith I, O'Brien JT, Thomas AJ. Prevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2020, 34(7), 990-998.
  • Donaghy PC, Firbank M, Mitra D, Petrides G, Lloyd J, Barnett N, Olsen K, Thomas AJ, O'Brien JT. Microbleeds in dementia with Lewy bodies. Journal of Neurology 2020, 267, 1491-1498.
  • Mc Ardle R, Del Din S, Donaghy P, Galna B, Thomas A, Rochester L. Factors that influence habitual activity in mild cognitive impairment and dementia. Gerontology 2020, 66, 197-208.
  • Schumacher J, Thomas AJ, Peraza LR, Firbank M, Cromarty R, Hamilton CA, Donaghy PC, O'Brien JT, Taylor JP. EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease. Alzheimers' Research & Therapy 2020, 12, 46.
  • Donaghy PC, Firbank M, Petrides G, Lloyd J, Barnett N, Olsen K, Thomas AJ, O'Brien JT. Diffusion imaging in dementia with Lewy bodies: Associations with amyloid burden, atrophy, vascular factors and clinical features. Parkinsonism and Related Disorders 2020, 78, 109-115.
  • Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT. Amyloid imaging and longitudinal clinical progression in dementia with Lewy bodies. American Journal of Geriatric Psychiatry 2020, 28(5), 573-577.
  • King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ. Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer’s disease. International Psychogeriatrics 2019, 31(4), 551-560.
  • King E, O'Brien J, Donaghy P, Williams-Gray CH, Lawson RA, Morris CM, Barnett N, Olsen K, Martin-Ruiz C, Burn DJ, Yarnall AJ, Taylor JP, Duncan GW, Khoo TK, Thomas A. Inflammation in Mild Cognitive Impairment due to Parkinson’s disease, Lewy Body disease and Alzheimer’s disease. International Journal of Geriatric Psychiatry 2019, 34(8), 1244-1250.
  • Mc Ardle R, Galna B, Donaghy P, Thomas A, Rochester L. Do Alzheimer’s and Lewy body disease have discrete pathological signatures of gait?. Alzheimer's and Dementia 2019, 15(10), 1367-1377.
  • Thomas A, Donaghy P, Roberts G, Colloby SJ, Barnett NA, Petrides G, Lloyd J, Olsen K, Taylor J-P, McKeith I, O'Brien JT. Diagnostic Accuracy of Dopaminergic Imaging in Prodromal Dementia with Lewy Bodies. Psychological Medicine 2019, 49(3), 396-402.
  • Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn DJ, Donaghy P, Morris CM, Taylor JP, Thomas AJ, Attems J, McKeith IG. Dementia with Lewy bodies: an update and outlook. Molecular Neurodegeneration 2019, 14, 5.
  • Mak E, Donaghy P, McKiernan E, Firbank M, Lloyd J, Petrides G, Thomas A, O'Brien J. Beta-amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies. Neurobiology of Aging 2019, 73, 74-81.
  • Roberts G, Lloyd JJ, Petrides GS, Donaghy PC, Kane JPM, Durcan R, Lawley S, Howe K, Sims AJ, Taylor JP, O'Brien JT, Thomas AJ. ¹²³I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults. Annals of Nuclear Medicine 2019, 33(6), 434-443.
  • King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor J-P, Thomas AJ. Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias. Journal of Neurology, Neurosurgery and Psychiatry 2018, 89(4), 339-345.
  • Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, Colloby SJ, Lloyd J, Petrides G, McKeith IG, Thomas AJ. Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies. Psychological Medicine 2018, 48(14), 2384-2390.
  • Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT. Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies. Movement Disorders 2018, 33(7), 1130-1138.
  • Lloyd JJ, Petrides G, Donaghy PC, Colloby SJ, Attems J, O'Brien JT, Roberts G, Thomas AJ. A new visual rating scale for Ioflupane imaging in Lewy body disease. NeuroImage: Clinical 2018, 20, 823-829.
  • Chee JN, Rapoport MJ, Molnar F, Herrmann N, O'Neill D, Marottoli R, Mitchell S, Tant M, Dow J, Ayotte D, Lanctôt KL, McFadden R, Taylor JP, Donaghy PC, Olsen K, Classen S, Elzohairy Y, Carr DB. Update on the Risk of Motor Vehicle Collision or Driving Impairment with Dementia: A Collaborative International Systematic Review and Meta-Analysis. American Journal of Geriatric Psychiatry 2017, 25(12), 1376-1390.
  • Donaghy PC, Barnett N, Olsen K, Taylor J-P, McKeith IG, O'Brien JT, Thomas AJ. Symptoms associated with Lewy body disease in mild cognitive impairment. International Journal of Geriatric Psychiatry 2017, 32(11), 1163-1171.
  • McKeith I, Taylor JP, Thomas A, Donaghy P, Kane J. Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease. Journal of Geriatric Psychiatry and Neurology 2016, 29(5), 249-253.
  • Donaghy P, Thomas AJ, O'Brien JT. Amyloid PET Imaging in Lewy Body Disorders. American Journal of Geriatric Psychiatry 2015, 23(1), 23-37.

• Conference Proceedings (inc. Abstracts)

  • Donaghy P, Blanc F, Thomas A, Bousiges O. FP CIT imaging in prodromal DLB. In: Balancing Cure with Care: Advances in Late Life Mental Health. 17th IPA International Congress. 2015, Berlin, Germany: Cambridge University Press.
  • Blanc F, Thomas A, Donaghy P, Bousiges O. Cortical thickness in dementia with Lewy bodies and Alzheimer's disease: A comparison of prodromal and dementia stages. In: 17th IPA International Conference: Balancing Cure with Care - Advances in Late Life Mental Health. 2015, Berlin, Germany: Cambridge University Press.
  • Bousiges O, Donaghy P, Blanc F, Thomas A. Conventional Alzheimer's biomarkers in cerebrospinal fluid are not pathological in patients with prodromal dementia with Lewy bodies. In: Balancing Cure with Care: Advances in Late Life Mental Health. 17th IPA International Congress. 2015, Berlin, Germany: Cambridge University Press.
  • Thomas A, Blanc F, Donaghy P, Bousiges O. Clinical profile of prodromal DLB: The Newcastle LewyPro study. In: 17th IPA International Congress. 2015, Berlin, Germany: Cambridge University Press.

• Note

  • Killen A, Olsen K, McKeith IG, Thomas AJ, O'Brien JT, Donaghy P, Taylor J-P. The challenges of COVID-19 for people with dementia with Lewy bodies and family caregivers. International Journal of Geriatric Psychiatry 2020, 35(12), 1431-1436.

• Reviews

  • Amin J, Erskine D, Donaghy PC, Surendranathan A, Swann P, Kunicki AP, Boche D, Holmes C, McKeith IG, O'Brien JT, Teeling JL, Thomas AJ. Inflammation in dementia with Lewy bodies. Neurobiology of Disease 2022, 168, 105698.
  • Rapoport MJ, Chee JN, Prabha T, Dow J, Gillespie I, Koppel S, Charlton JL, O'Neill D, Donaghy PC, Ho AO, Taylor J-P, Tant M. A Systematic Review of the Risks of Motor Vehicle Crashes Associated with Psychiatric Disorders / Une revue systématique des risques d’accidents de véhicules automobiles associés à des troubles psychiatriques. Canadian Journal of Psychiatry 2023, 68(4), 221-240.
  • Durcan R, Donaghy P, Osborne C, Taylor J-P, Thomas AJ. Imaging in prodromal dementia with Lewy bodies: Where do we stand?. International Journal of Geriatric Psychiatry 2019, 34(5), 635-646.
  • Rapoport MJ, Chee JN, Carr DB, Molnar F, Naglie G, Dow J, Marottoli R, Mitchell S, Tant M, Herrmann N, Lanctot KL, Taylor J-P, Donaghy PC, Classen S, O'Neill D. An International Approach to Enhancing a National Guideline on Driving and Dementia. Current Psychiatry Reports 2018, 20, 16.
  • Donaghy PC, O'Brien JT, Thomas AJ. Prodromal dementia with Lewy bodies. Psychological Medicine 2015, 45(2), 259-268.
  • Donaghy PC, McKeith IG. The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis. Alzheimer's Research & Therapy 2014, 6(4), 46.