Staff Profile

Area of Expertise

cardiovascular genetics, cancer genetics, endocrine genetics, clinical education

CURRENT RESEARCH & DEVELOPMENT ACTIVITY

• Transforming Genomic Medicine Initiative (TGMI) July 2017 – current : collaborator on national project which addresses many of the requirements that will be required for the systematic adoption of genomic medicine across the NHS.

• Tumor Familiengeschichtetriage April 2017 – current : joint project with Professor Gabriela Möslein of Witten-Herdecke University and HELIOS University Hospital’s Institute for Hereditary Tumours, Wuppertal, Germany to introduce cancer family history triage.

• NaGen: Proyecto Genoma 1000 Navarra 2016 – current: advisor on the Strategic Steering Committee of the Navarran regional genome project.

• Molecular PROfiling in Early Clinical Trials - North East (PROSPECT-NE). Sir Bobby Robson Foundation 2015 – current (IRAS 216629): establishment of somatic mutation panel testing in tumours from patients with treatment-refractory cancer being recruited to phase 1 studies.

• 100,000 Genomes Project (Clinical Lead, North East & North Cumbria NHS Genomic Medicine Centre – Rare Diseases and Cancer) 2015-current: national translational service development project to introduce whole genome sequencing into routine clinical practice. 

MB BS Stage 1 Newcastle & Durham

MB BS CSIM3 Newcastle & NUMED

postgraduate teaching in many different settings 

• Brennan P, Claber O, Brennan T. Cancer family history triage: a key step in the decision to offer screening and genetic testing. Familial Cancer 2013, 12(3), 497-502.
• Brennan P, Parkes O. Case-finding in Fabry disease: experience from the North of England. Journal of Inherited Metabolic Disease 2014, 37(1), 103-107.
• Jafri M, Whitworth J, Rattenberry E, Vialard L, Kilby G, Kumar A, Izatt L, Lalloo F, Brennan P, Cook J, Morrison PJ, Canham N, Armstrong R, Brewer C, Tomkins S, Donaldson A, Barwell J, Cole TR, Atkinson AB, Aylwin S, Ball SG, Srirangalingam U, Chew SL, Evans DGR, Hodgson SV, Irving R, Woodward E, Macdonald F, Maher ER. Evaluation of SDHB, SDHD and VHL gene susceptibility testing in the assessment of individuals with non-syndromic phaeochromocytoma, paraganglioma and head and neck paraganglioma. Clinical Endocrinology 2013, 78(6), 898-906.
• Wilson BT, Jensen SA, McAnulty CPP, Brennan P, Handford PA. Juvenile idiopathic arthritis, mitral valve proplapse and a familial variant involving the integrin-binding fragment of FBN1. American Journal of Medical Genetics Part A 2013, 161(8), 2047-2051.
• Ball SG, Brennan P, Lennard TWJ. Familial endocrine disease: genetics, clinical presentation and management. In: Lennard, TWJ, ed. Endocrine Surgery. London: Saunders Elsevier, 2009, pp.99-120.
• Azad J, Brennan P, Carmichael AJ. New mutation identified in adult onset erythropoeitic protoporphyria. Clinical and Experimental Dermatology 2013, 38(6), 601-605.
• Rafi I, Qureshi N, Lucassen A, Modell M, Elmslie F, Kai J, Kirk M, Starey N, Goff S, Brennan P, Hodgson S. 'Over-the-counter' genetic testing: What does it really mean for primary care?. British Journal of General Practice 2009, 59(561), 283-287.
• Lee D, Brennan P, Lord S. The extent and consequences of diagnostic uncertainty in individuals assessed for arrhythmogenic right ventricular cardiomyopathy. In: Congress of the European Society of Cardiology (ESC). 2012, Munchen, Germany: Oxford University Press.
• Sayer J, Haslam P, Brennan P. Multiple parapelvic cysts leading to a diagnosis of Fabry disease. In: 8th Annual European Round Table on Fabry Disease. 2007, Rome, Italy: Clinical Therapeutics: Elsevier.
• Campbell J, Kent R, O'Dair L, Brennan P, Goodship JA, Prem C. Marfan syndrome: Audit of diagnosis and follow-up arrangements. In: Journal of Medical Genetics: British Human Genetics Conference. 2005, York, UK: BMJ Group.
• Oliver J, Goodfellow J, Hammond A, Farrer M, Stewart M, Bourke J, Brennan P. The impact of cardiac genetics nurses in a pre-genetic screening clinic. In: 12th Annual Spring Meeting on Cardiovascular Nursing. 2012, Copenhagen, Denmark: Sage Publications Ltd.
• Brennan P. Clinical Opinion: Revised diagnostic criteria for Marfan syndrome. Journal of the Royal College of Physicians of Edinburgh 2011, 41, 223-223.
• Oliver J, Goodfellow J, Smyth L, Bourne R, Farrer M, Brennan P. Using patient experiences to develop a pre cardiac genetic service around family needs. British Journal of Cardiac Nursing 2011, 6(6), 291-294.
• Steward CG, Newbury-Ecob RA, Hastings R, Smithson SF, Quarrell OW, Kulik W, Wanders R, Jones M, Williams M, Cresswell JL, Gonzalez IL, Brennan P. Barth syndrome: an X-linked cause of fetal cardiomyopathy and stillbirth. Prenatal Diagnosis 2010, 30(10), 970-976.
• Brennan P. Delivering a clinical cardiovascular service. In: Kumar, D; Elliot, P, ed. Clinical Cardiovascular Genetics: Principles and Practice. New York: Oxford University Press, 2010.
• Sayer JA, Haslam P, Brennan P. Parapelvic cysts leading to a diagnosis of Fabry disease. Kidney International 2008, 74(10), 1366.
• Brennan P, Claber O, Shaw T. The Teesside Cancer Family History Service: Change management and innovation at cancer network level. Familial Cancer 2007, 6(2), 181-187.
• Brown S, Ahmed J, Zwolinski S, Brennan P, Rajan N. A novel link between keratoderma and cardiomyopathy: Contiguous gene deletion involving the desmoglein gene cluster. British Journal of Dermatology 2018, 178(1), 284-285.
• Sayer JA, McCloskey S, Brennan P. Variable phenotypic presentations of renal involvement in Fabry disease: A case series [version 1; referees: 2 approved]. F1000Research 2018, 7, 356.
• Midttun O, Theofylaktopoulou D, McCann A, Fanidi A, Muller DC, Meyer K, Ulvik A, Zheng W, Shu X-O, Xiang Y-B, Prentice R, Thomson CA, Pettinger M, Giles GG, Hodge A, Cai Q, Blot WJ, Wu J, Johansson M, Hultdin J, Grankvist K, Stevens VL, McCullough ML, Weinstein SJ, Albanes D, Langhammer A, Hveem K, Naess M, Sesso HD, Gaziano JM, Buring JE, Lee I-M, Severi G, Zhang X, Han J, Stampfer MJ, Smith-Warner SA, Zeleniuch-Jacquotte A, Le Marchand L, Yuan J-M, Butler LM, Koh W-P, Wang R, Gao Y-T, Ericson U, Sonestedt E, Ziegler RG, Freedman ND, Visvanathan K, Jones MR, Relton C, Brennan P, Johansson M, Ueland PM. Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. American Journal of Clinical Nutrition 2017, 105(6), 1314-1326.
• Brown S, Ahmed J, Zwolinski S, Brennan P, Rajan N. A novel contiguous heterozygous deletion involving the desmoglein 2 and desmocollin 2 genes is associated with arrhythmogenic right ventricular cardiomyopathy. In: BAD/RCP Medical Dermatology Meeting. 2016, Royal College of Physicians, London: Wiley-Blackwell Publishing Ltd.
• Owens M, Kivuva E, Quinn A, Brennan P, Caswell R, Allen HL, Vaidya B, Ellard S. SOS1 frameshift mutations cause pure mucosal neuroma syndrome, a clinical phenotype distinct from multiple endocrine neoplasia type 2B. Clinical Endocrinology 2016, 84(5), 715-719.
• Brady M, Montgomery E, Brennan P, Mohindra R, Sayer JA. Diagnosing Fabry disease-delays and difficulties within discordant siblings. QJM 2015, 108(7), 585-590.
• Lang Kuhs KA, Anantharaman D, Waterboer T, Johansson M, Brennan P, Michel A, Willhauck-Fleckenstein M, Purdue MP, Holcatova I, Ahrens W, Lagiou P, Polesel J, Simonato L, Merletti F, Healy CM, Kjaerheim K, Conway DI, Macfarlane TV, Thomson P, Castellsague X, Znaor A, Black A, Huang W-Y, Krogh V, Trichopoulou A, Bueno-De-Mesquita HBAS, Clavel-Chapelon F, Weiderpass E, Ekstrom J, Riboli E, Tjonneland A, Sanchez M-J, Travis RC, Hildesheim A, Pawlita M, Kreimer AR. Human Papillomavirus 16 E6 Antibodies in Individuals without Diagnosed Cancer: A Pooled Analysis. Cancer Epidemiology, Biomarkers and Prevention 2015, 24(4), 683-689.
• Brennan P. Breast cancer risk in MEN1 – a cancer genetics perspective. Clinical Endocrinology 2014, 82(3), 327-329.
• Brennan P, Ball SG, Lennard TWJ. Familial endocrine disease: genetics, clinical presentation and management. In: Lennard, T.W.J, ed. Endocrine Surgery: A Companion to Specialist Surgical Practice. London: Saunders Elsevier, 2014, pp.98-124.
• Dronamraju S, Oppong K, Nayar M, Brennan P, Henderson A, Douglas F, O'Dair L, Charnley R. Pancreatic Cancer Screening - are we doing it right?. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: John Wiley & Sons Ltd.
• Brennan P, Claber O, Brennan T, O'Dair L, Oliver J, Ball S, Miller M. Mainstreaming initiatives in the North East: innovation, leadership and a new role for tertiary services. In: JOURNAL OF MEDICAL GENETICS. 2011, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND: B M J PUBLISHING GROUP.
• Ormondroyd L, Blair E, McClymont C, McKeown P, McOsker J, Stewart F, Brennan P, Ecob RN, Stewart G, Mehta S, Newman W, Metcalfe K, Storrar LK, Watkins H. UK GenetICC - Inherited Cardiac Conditions register. In: JOURNAL OF MEDICAL GENETICS. 2011, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND: B M J PUBLISHING GROUP.
• Khoury L, Douglas SF, Brennan P, Henderson A. An audit of Li Fraumeni syndrome and Li-Fraumeni like syndrome. In: JOURNAL OF MEDICAL GENETICS. 2010, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND: B M J PUBLISHING GROUP.
• Theofylaktopoulou D, Midttun O, Ueland PM, Meyer K, Fanidi A, Zheng W, Shu X-O, Xiang Y-B, Prentice R, Pettinger M, Thomson CA, Giles GG, Hodge A, Cai Q, Blot WJ, Wu J, Johansson M, Hultdin J, Grankvist K, Stevens VL, McCullough MM, Weinstein SJ, Albanes D, Ziegler R, Freedman ND, Langhammer A, Hveem K, Naess M, Sesso HD, Gaziano JM, Buring JE, Lee I-M, Severi G, Zhang X, Stampfer MJ, Han J, Smith-Warner SA, Zeleniuch-Jacquotte A, Le Marchand L, Yuan J-M, Wang R, Butler LM, Koh W-P, Gao Y-T, Rothman N, Ericson U, Sonestedt E, Visvanathan K, Jones MR, Relton C, Brennan P, Johansson M, Ulvik A. Impaired functional vitamin B6 status is associated with increased risk of lung cancer. International Journal of Cancer 2018, 142(12), 2425-2434.