Staff Profile

Introduction

I am an ophthalmologist with a specialist interest in the visual problems of children. I undertake clinical research in this area with the aim of improving the effectiveness and efficiency of the delivery of children's ophthalmic services. I have also developed a multidisciplinary service for the assessment of visual symptoms experienced by patients with dementia and other neurodegenerative diseases.

Qualifications

1979 Bachelor of Arts (Natural Sciences). Class II.1

1981 Bachelor of Medicine and Surgery

1985 Diploma in Ophthalmology

1986 Fellow of the Royal College of Surgeons of England 

1988 Fellow of the Royal College of Ophthalmologists  

2013 PhD (Newcastle)    

 

Professional Experience:          

1982      House Physician, Addenbrookes' Hospital   

1982/3   House Surgeon, Manchester Royal Infirmary  

1983      Casualty Officer, University College Hospital, London  

1984      S.H.O. Ophthalmology, St. Bartholomew's Hospital, London 

1984/5   S.H.O. Ophthalmology, Western Ophthalmic Hospital, London 

1985/6   S.H.O. Medical and Surgical Neurology, Addenbrookes' Hospital 

1986/8   Registrar Ophthalmology, West Yorkshire Rotation 

1988/90 Senior Registrar Ophthalmology, Nottingham University Hospital  

1990/1 Clinical Fellow, Ophthalmology, Hospital for Sick Children, Toronto  

1991 -    Consultant Ophthalmologist, Royal Victoria Infirmary, Newcastle upon Tyne        

 

Newcastle University Appointments:   

           

1991/8   Honorary Lecturer

1995/8   Acting Head of University Department of Ophthalmology

1995 -    Examiner Part 1 and 2 Final M.B

1998/03 Senior Lecturer, A + B appointment

1995/03 Course Director, Undergraduate Ophthalmology

1999/01 Associate Clinical SubDean, Faculty of Medicine

2003 -    Reader in Ophthalmology

2003/9   Co-Director, North East Centre for  Age Related Eye Disease Research

2007/10 Theme leader, Vision Theme, Specialist Academic Medical Centre for Ageing

2009/11 Academic Lead for Ophthalmology, Board of Clinical specialities

2010-     Associate Fellow, Graduate school, Faculty of Medicine 

 

Newcastle upon Tyne Hospitals NHS Foundation Trust Appointments

 

2010/13 Head of Department of Ophthalmology

2013-     Clinical Director: Plastic Surgery, Ophthalmology and Dermatology 

 

 External Examiner      

 

 2004      University of London MD

 2005          University of Manchester PhD

 2007      University of Nottingham PhD

 2009      Queensland University of Technology PhD

 2009      University of London      MD      

 

Visiting Professorships           

 

 2004      First Medical Faculty, Zhengzhou University, China

 

External Research Roles         

 

 2007/10 Non Executive Chair to the Ulverscroft Vision Research Group, Institute of Child Health

 

Trusteeships 

  

 2007-     Trustee of Henshaw’s Society for Blind People (North East)

 

Prizes 

 2007      Royal College of Ophthalmologists Nettleship Research Medal

 

  

 

           

 

           

 

                      

• Pediatric Eye Disease Investigator Group, Writing Committee, Wallace DK, Lazar EL, Holmes JM, Repka MX, Cotter SA, Chen AM, Kraker RT, Beck RW, Clarke MP, Lorenzana IJ, Petersen DB, Roberts JT, Suh DW. A Randomized Trial of Increasing Patching for Amblyopia. Ophthalmology 2013, 120(11), 2270-2277.
• Archibald NK, Hutton SB, Clarke MP, Mosimann UP, Burn DJ. Visual exploration in Parkinson's disease and Parkinson's disease dementia. Brain 2013, 136(3), 739-750.
• Killen AJ, Firbank MJ, Collerton D, Clarke MP, Jefferis J, Taylor J-P, McKeith IG, Mosimann U. The assessment of cognition in visually impaired older adults. Age and Ageing 2013, 42(1), 98-102.
• Jefferis JM, Clarke MP, Mosimann UP, O'Brien JT, Taylor JP. The influence of two common dementia types on visual symptoms. Acta Ophthalmologica 2013, 91(2), e159-e160.
• Han RC, Jefferis JM, Taylor JP, Archibald NK, Clarke MP. A novel, multidisciplinary clinic for complex visual problems in older people. Eye 2012, 26(12), 1536-1541.
• Buck D, McColl E, Powell CJ, Shen J, Sloper J, Steen N, Taylor R, Tiffin P, Vale L, Clarke MP. Surgery versus Active Monitoring in Intermittent Exotropia (SamExo): study protocol for a pilot randomised controlled trial. Trials 2012, 13, 192.
• Buck D, Powell CJ, Sloper JJ, Taylor R, Tiffin P, Clarke MP, for the Improving Outcomes in Intermittent Exotropia (IOXT) Study group. Surgical intervention in childhood intermittent exotropia: current practice and clinical outcomes from an observational cohort study. British Journal of Ophthalmology 2012, 96(10), 1291-1295.
• Jefferis JM, Collerton J, Taylor JP, Jagger c, Kingston A, Davies K, Kirkwood T, Clarke MP. The impact of visual impairment on mini-mental state examination scores in the Newcastle 85+ study. Age and Ageing 2012, 41(4), 565-568.
• Buck D, Powell CJ, Rahi J, Cumberland P, Tiffin P, Taylor R, Slope J, Davis H, Dawson E, Clarke MP. The improving outcomes in intermittent exotropia study: outcomes at 2 years after diagnosis in an observational cohort. BMC Ophthalmology 2012, 12(1), 1.
• Buck D, Clarke MP, Powell C, Tiffin P, Drewett RF. Use of the PedsQL in childhood intermittent exotropia: estimates of feasibility, internal consistency reliability and parent-child agreement. Quality of Life Research 2012, 21(4), 727-736.
• Jefferis JM, Mosimann UP, Taylor JP, Clarke MP. "Do your eyes play tricks on you?" Asking older people about visual hallucinations in a general eye clinic. International Psychogeriatrics 2011, 23(6), 1014-1015.
• Jefferis JM, Mosimann UP, Clarke MP. Republished review: Cataract and cognitive impairment: a review of the literature. Postgraduate Medical Journal 2011, 87(1031), 636-642.
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. Retinal thickness in Parkinson's disease. Parkinsonism & Related Disorders 2011, 17(6), 431-436.
• Serrano-Pedraza I, Manjunath V, Osunkunle O, Clarke MP, Read JCA. Visual Suppression in Intermittent Exotropia during Binocular Alignment. Investigative Ophthalmology & Visual Science 2011, 52(5), 2352-2364.
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. Visual symptoms in Parkinson's disease and Parkinson's disease dementia. Movement Disorders 2011, 26(13), 2387-2395.
• Porteous AM, Clarke MP. Medically unexplained visual symptoms in children and adolescents: an indicator of abuse or adversity?. Eye 2009, 23(9), 1866-1867.
• Nassar MM, Dickinson AJ, Neoh C, Powell C, Buck D, Galal E, Clarke MP. Parameters predicting outcomes of strabismus surgery in the management of Graves' ophthalmopathy. In: Journal of AAPOS: 33rd Annual Meeting of the American Association for Pediatric Ophthalmology and Strabismus. 2009, Seattle, Washington, USA: Mosby, Inc.
• Archibald NK, Clarke MP, Mosimann UP, Burn DJ. The retina in Parkinson’s disease: A review. Brain 2009, 132(5), 1128-1145.
• Clarke MP. Vitreoretinal traction is a major factor in causing the haemorrhagic retinopathy of abusive head injury? - No. Eye 2009, 23(9), 1761-1763.
• Mosimann UP, Collerton D, Dudley R, Meyer TD, Graham G, Dean JL, Bearn D, Killen A, Dickinson L, Clarke MP, McKeith IG. A semi-structured interview to assess visual hallucinations in older people. International Journal of Geriatric Psychiatry 2008, 23(7), 712-718.
• Buck D, Clarke MP, Haggerty H, Hrisos S, Powell C, Sloper J, Strong NP. Grading the severity of intermittent distance exotropia: The revised Newcastle Control Score. British Journal of Ophthalmology 2008, 92(4), 577.
• Clarke MP. Intermittent exotropia. Journal of Pediatric Ophthalmology and Strabismus 2007, 44(3), 153-157.
• Holmes JM, Clarke MP. Amblyopia. The Lancet 2006, 367(9519), 1343-1351.
• Clarke MP. Modern Treatment of Amblyopia. In: Lorenz, B., Moore, A.T, ed. Pediatric Ophthalmology, Neuro-Ophthalmology, Genetics. Berlin, Germany: Springer, 2006, pp.37-48.
• Hrisos S, Clarke MP, Kelly T, Henderson J, Wright CM. Unilateral visual impairment and neurodevelopmental performance in preschool children. British Journal of Ophthalmology 2006, 90(7), 836-838.
• Adams WE, Hrisos S, Richardson S, Davis H, Frisby JP, Clarke MP. Frisby Davis distance stereoacuity values in visually normal children. British Journal of Ophthalmology 2005, 89(11), 1438-1441.
• Richardson SR, Wright CM, Hrisos S, Buck D, Clarke MP. Stercoacuity unilateral visual impairment detected at preschool screening: Outcomes from a randomized controlled trial. Investigative Ophthalmology and Visual Science 2005, 46(1), 150-154.
• Clarke MP. Reform of undergraduate medical teaching in the United Kingdom: Evangelism triumphs over common sense for ophthalmology. British Medical Journal 2004, 329(7469), 799-800.
• Richardson SR, Clarke MP. Surgery for Intermittent Exotropia. International Review of Modern Surgery 2004, 36–37.
• Hrisos S, Clarke MP, Wright CM. The emotional impact of amblyopia treatment in preschool children: Randomized controlled trial. Ophthalmology 2004, 111(8), 1550-1556.
• Haggerty H, Richardson S, Hrisos S, Strong NP, Clarke MP. The Newcastle Control Score: a new method of grading the severity of intermittent exotropia. British Journal of Ophthalmology 2004, 88(2), 233-235.
• Mckie JN, Mohamed J, Li Z, Arris CE, Hiscott P, Sheridan C, Langton KP, Barker MD, Clarke MP, Bevitt DJ. Expression of ADAMTS metalloproteinases in ARPE19 cells: Transcriptional regulation by TNF alpha. In: Investigative Ophthalmology & Visual Science: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2003, Ft Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Ressiniotis T, Zeki SM, Clarke MP, Mitchell KW. Improved illumination for the Perkins applanation tonometer. Ophthalmic and Physiological Optics 2003, 23(6), 513-516.
• Henderson A, Lynch SA, Clarke M, Williamson K, van Heyningen V. Microphthalmia associated with neurofibromatosis 1 and PAX6 mutation. In: Journal of Medical Genetics: British Human Genetics Conference. 2003, York, UK: BMJ Group.
• Clarke MP, Wright CM, Hrisos S, Anderson JD, Henderson J, Richardson SR. Randomised controlled trial of treatment of unilateral visual impairment detected at preschool vision screening. British Medical Journal 2003, 327(7426), 1251-1254.
• Clarke MP, Haggerty H, Richardson S, Hrisos S. Surgical decision making in intermittent distance exotropia using the Newcastle Control Score. In: Investigative Ophthalmology & Visual Science: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2003, Ft Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Clarke M, Richardson S, Hrisos S, Anderson J, Henderson J, Wright C. The UK amblyopia treatment trial: Visual acuity and stereoacuity values in treated and untreated unilateral straight eyed amblyopia. In: Progress in Strabismology: 9th Meeting of the International Strabismological Association. 2003, Sydney, Australia: Taylor & Francis.
• Brennan R, Clarke MP, Redfearn A, Gibson M, Lazaro C, Mitchell KW. Visual impairment following shaking/impact injury in infancy: A clinical and electrophysiological study. In: Investigative Ophthalmology & Visual Science: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2003, Ft Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Clarke M. The assessment and management of strabismus in childhood. Current Paediatrics 2002, 12(4), 269-274.
• Herrema I, Clarke M. Anaesthesia for retinoblastoma screening - a dilemma. Anaesthesia 2001, 56(5), 486-487.
• Clarke M, Mitchell KW, Goodship J, McDonnell S, Barker MD, Griffiths ID, McKie N. Clinical features of a novel TIMP-3 mutation causing Sorsby's fundus dystrophy: implications for disease mechanism. British Journal of Ophthalmology 2001, 85(12), 1429-1431.
• Griffiths PG, Barron MJ, Durham S, Johnson MA, Bristow E, Clarke MP, Lai-Cheong J, Turnbull DM. Distribution of mitochondrial dysfunction in ageing ocular tissues. In: Annual Meeting of the Association for Research in Vision and Ophthalmology. 2001, Fort Lauderdale, Florida, USA: Association for Research in Vision and Ophthalmology.
• Hrisos S, Clarke MP, Anderson JD, Wright C. Emotional Impact of Amblyopia Treatment on Preschool Children. In: Annual Meeting of the American Academy of Ophthalmology (AAO). 2001, New Orleans, Louisiana, USA.
• Barron MJ, Johnson MA, Andrews RM, Clarke MP, Griffiths PG, Bristow E, He L, Durham S, Turnbull DM. Mitochondrial abnormalities in ageing macular photoreceptors. Investigative Ophthalmology and Visual Science 2001, 42(12), 3016-3022.
• Boyle NJ, Clarke MP, Figueiredo F. Reduced corneal sensation and severe dry eyes in a child with fetal valproate syndrome. Eye 2001, 15(5), 661-662.
• Ziakas NG, Cottrell DG, Milligan DWA, Pennefather PM, Bamashmus MA, Clarke MP. Regionalisation of retinopathy of prematurity (ROP) screening improves compliance with guidelines: an audit of ROP screening in the Northern Region of England. British Journal of Ophthalmology 2001, 85(7), 807-810.
• McKie JN, Bevitt DJ, Lorite MJ, Pimenides D, Clarke MP, Langton KP, Barker MD. RPE cells express several members of the metallo-disintegrin (ADAM) family of extracellular matrix modifying enzymes. Investigative Ophthalmology & Visual Science 2001, 42(4), 1197.
• Ziakas NG, Wong CP, Ramsay AS, Bamashmus MA, Forsyth RJ, Eyre JA, Clarke MP. Visual impairment in children with acute non-traumatic coma. Journal of Pediatric Ophthalmology and Strabismus 2001, 38(1), 6-10.
• Clarke MP, Barker MD, Langton KP, Curtis A, Goodship JA, Bond PM, Mitchell KA, McKie N. A novel TIMP-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2000.
• Langton KP, McKie N, Curtis A, Goodship JA, Bond PM, Barker MD, Clarke M. A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy. Journal of Biological Chemistry 2000, 275(35), 27027-27031.
• Barron MJ, Andrews RM, Griffiths PG, Johnson MA, Bristow E, He LP, Durham S, Turnbull DM, Clarke MP. The macular photoreceptor layer accumulates the mitochondrial DNA(4977) deletion with age. In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2000.
• Pennefather PM, Tin W, Clarke MP, Dutton J, Fritz S, Hey EN. Bias due to incomplete follow up in a cohort study. British Journal of Ophthalmology 1999, 83(6), 643-645.
• Hanson I, Churchill A, Love J, Axton R, Moore T, Clarke M, Meire F, van Heyningen V. Missense mutations in the most ancient residues of the PAX6 paired domain underlie a spectrum of human congenital eye malformations. Human Molecular Genetics 1999, 8(2), 165-172.
• Pennefather PM, Clarke MP, Strong NP, Cottrell DG, Dutton J, Tin W. Risk factors for strabismus in children born before 32 weeks' gestation. British Journal of Ophthalmology 1999, 83(5), 514-518.
• Stafanous SN, Clarke MP, Ashton H, Mitchell KW. The effect of long-term use of benzodiazepines on the eye and retina. Documenta Ophthalmologica 1999, 99(1), 55-68.
• Gilchrist ID, Brown V, Findlay JM, Clarke MP. Using the eye-movement system to control the head. Proc. R. Soc .Lond. B 1998, 265, 1831-1836.
• Clarke M., Mitchell KW, McDonnell S. Electrophysiology in macular dystrophies. Documenta Ophthalmologica 1997, 92, 325 - 339.
• Pennefather PM, Tin W, Strong NP, Clarke MP, Dutton J, Cottrell DG. Refractive errors at two years of infants born before 32 weeks gestation. Eye 1997, 11, 736-743.
• Clarke MP, Mitchell KW, Gibson M. The prognostic value of flash visual evoked potentials in the assessment of non-ocular visual impairment in infancy in infants. Eye 1997, 11, 398-402.
• Bray LC, Clarke MP, Jarvis SM, Francis PM, Colver A. Pre School Vision Screening: A Prospective Comparative Evaluation. Eye 1996, 10, 714-718.
• MacLean H, Clarke MP, Strong NP, Kernahan J, Ashraf S. Primary ocular relapse in acute lymphoblastic leukaemia. Eye 1996 1996, 10, 719-722.
• Pennefather PM, Tin W, Clarke MP, Fritz S, Strong NP. Retinopathy of prematurity in a controlled trial of prophylactic surfactant treatment. British Journal of Ophthalmology 1996, 80, 420-424.
• Sullivan TJ, Clarke MP, Tuli R, Devenyi R, Harvey P. General Anaesthesia with endotracheal intubation for cryotherapy for retinopathy of prematurity. European Journal of Ophthalmology 1995, 5(3), 187-191.
• Pennefather PM, Clarke MP, Strong NP, Cotterell D, Fritz S, Tin W. Ocular outcome in children born before 32 weeks gestation. Eye 1995, 9 (Suppl.), 26-30.
• West J, Askin G, Clarke M, Vernon S. Loss of vision following scoliosis surgery. Br. J. Ophthalmol 1990, 74(243-244).
• Clarke M., Vernon S., Pearson J., Matthews C. The effect of pupil size on measurements of lens opacity with the Lens Opacity Meter 701. British Journal of Ophthalmology 1990, 74, 526-527.
• Clarke M., Yap M., Weatherill J. Do intraocular lenses containing ultraviolet filters protect against macular oedema?. Acta Ophthalmologica 1989, 67, 593-596.
• Clarke M., Yap M., Weatherill J. Pattern ERG and Contrast Sensitivity findings in Waldenstrom's Macroglobulinaemia. Eye 1987, 1, 750-753.
• Clarke M., Jagger J. Is acute glaucoma a symptom of diabetes?. British Journal of Ophthalmology 1986, 70, 877-878.
• Joyce KE, Beyer F, Thomson RG, Clarke MP. A systematic review of the effectiveness of treatments in altering the natural history of intermittent exotropia. British Journal of Ophthalmology 2015, 99(4), 440-450.
• Jefferis JM, Connor AJ, Clarke MP. Amblyopia. BMJ 2015, 351, h5811.
• Read J, Vancleef K, Serrano-Pedraza I, Morgan G, Sharp C, Clarke M. ASTEROID: Accurate STEReoacuity measurement in the eye clinic. In: 38th European Conference on Visual Perception (ECVP). 2015, Liverpool, UK: Sage Publications Ltd.
• Jefferis JM, Clarke MP, Taylor JP. Effect of cataract surgery on cognition, mood, and visual hallucinations in older adults. Journal of Cataract & Refractive Surgery 2015, 41(6), 1241-1247.
• Jefferis JM, Clarke MP, Taylor JP. Reply to: Colin et al. Effect of cataract surgery on visual hallucinations in older adults Journal of Cataract & Refractive Surgery, Volume 41, Issue 10, October 2015, Pages 2342-2343. Journal of Cataract & Refractive Surgery 2015, 41(10), 2343-2344.
• Buck D, Hogan V, Powell CJ, Sloper JJ, Speed C, Taylor RH, Tiffin P, Clarke MP, SamExo Surg Versus Active. Surrendering control, or nothing to lose: Parents' preferences about participation in a randomised trial of childhood strabismus surgery. Clinical Trials 2015, 12(4), 384-393.
• Buck D, Hogan V, Powell CJ, Sloper JJ, Speed C, Taylor RH, Tiffin P, Clarke MP, on behalf of the SamExo (Surgery versus Active Monitoring in Intermittent Exotropia) trial. Surrendering control, or nothing to lose: Parents’ preferences about participation in a randomised trial of childhood strabismus surgery. Clinical Trials 2015, 12(4), 384-393.
• Lecouturier J, Clarke MP, Errington G, Hallowell N, Murtagh MJ, Thomson R. Treating childhood intermittent distance exotropia: a qualitative study of decision making. BMC Opthalmology 2015, 15, 112.
• Clarke M, Powell C, Buck D, McColl E, Speed C, Hogan V, Vale L, Shen J, Steen N, Nassar M, Thomson R, Joyce K, Beyer F, Taylor R, Tiffin P, Sloper J. An External Pilot Study to Test the Feasibility of a Randomised Controlled Trial comparing Eye Muscle Surgery against Active Monitoring for Childhood Intermittent Distance Exotropia [X(T)]. Pilot Rehearsal Trial and Feasibility Study, Final Report to the NIHR HTA, HTA Project 09/01/20, July 2013. 2014. In Press.
• Jefferis JM, Clarke MP, Taylor JP, Brittain KR. Challenges for the cataract surgeon treating people with dementia: a qualitative study exploring anesthetic choices. Clinical Ophthalmology 2014, 8, 1993-1999.
• Buck D, Ali N, Tiffin P, Taylor RH, Powell CJ, Clarke MP. Child-rated and parent-rated quality of life in childhood intermittent exotropia: findings from an observational cohort study. Ophthalmology Research: An International Journal 2014, 3(3), 59-66.
• Jefferis JM, Taylor J-P, Clarke MP. Does cognitive impairment influence outcomes from cataract surgery? Results from a 1-year follow-up cohort study. British Journal of Ophthalmology 2014, 99(3), 412-417.
• Clarke M. NHS sight tests include unevaluated screening examinations that lead to waste. BMJ 2014, 348, 1-2.
• Kulp MT, Cotter SA, Connor AJ, Clarke MP. Should amblyopia be treated?. Ophthalmic and Physiological Optics 2014, 34(2), 226-232.
• Clarke M. The Waste in NHS eye tests: Author's reply to Elliott, Parkins, Shah and colleagues, and Dhua. BMJ 2014, 348, g3057.
• Buck D, Powell C, Sloper J, Taylor R, Tiffin P, Clarke MP. Authors' response: After intermittent exotropia surgery, consecutive esotropia: good or bad? by K K Shoaib. British Journal of Ophthalmology 2013, 97(6), 797-798.
• Makin SM, Redman J, Mosimann UP, Dudley R, Clarke MP, Colbourn C, Collerton D. Complex visual hallucinations and attentional performance in eye disease and dementia: a test of the Perception and Attention Deficit model. International Journal of Geriatric Psychiatry 2013, 28(12), 1232-1238.