Staff Profile

I am a biostatistician and genetic epidemiologist with extensive experience in health research and teaching in both academic and industry settings. Since 1993, I have designed and implemented health studies, analysed clinical trials and conducted training courses in statistical analysis and research methods for government institutions, pharmaceutical companies and international organizations. I have held research and academic appointments at Imperial College London, University of Oxford, University of Göttingen (Germany) and University of the Philippines. Currently, I lead and teach modules offered in the Public Health suite of programmes at Newcastle University. I also lead the Artificial Intelligence in Health Research initiative and serve as research/statistical adviser for the NIHR Research Support Service.

Education / Qualifications

(PhD, MSc, BSc, GradStat, FRSPH, SFHEA, PG Cert LTHE)

Ph.D. in Applied Statistics and Empirical Methods (Genetic Epidemiology), Centre for Statistics, Georg-August-Universität Göttingen, Germany

Dr. rer. nat., Faculties of Mathematics and Natural Sciences, Georg-August-Universität Göttingen, Germany

M.Sc. in Public Health (Biostatistics), University of the Philippines Manila

B.Sc. in Public Health, University of the Philippines Manila

Certificate in Oxford Executive Leadership Programme, University of Oxford, United Kingdom

Certificate in Pharmacogenomics in Oncology, Universitätsmedizin Göttingen, Germany

Postgraduate Certificate in Learning and Teaching in Higher Education, University of London, United Kingdom

Certificate in Effective Online Tutoring, Department for Continuing Education, University of Oxford, United Kingdom

Professional Membership

Senior Fellow of the Higher Education Academy, United Kingdom

Fellow of the Royal Statistical Society, United Kingdom

Fellow of the Royal Society for Public Health, United Kingdom

My current research interests include the following:

•   Modelling techniques that could be efficiently applied to answer questions on identification of disease states, treatment efficacy, treatment cost-effectiveness and disease prevention

•   Understanding the determinants of health and disease using real world data and big data analytical tools in biostatistics, epidemiology and artificial intelligence (AI)

•   Applications of AI in biomarker studies, healthcare and clinical trials

•   Population and family-based analysis methods in genetics

I am currently engaged in several MRC and NIHR funded studies as co-investigator and senior statistician. I serve in various trial steering committees and data monitoring committees nationwide. I also serve in the Newcastle ethics committee and in the AI Working Group. Having been involved in international consortiums, I am open to international research collaborations in my current fields of interest.

For more information on my research projects and publications, please see: 

https://www.researchgate.net/profile/Jingky_Lozano-Kuehne, ORCID: https://orcid.org/0000-0002-7372-0725, Google Scholar

I supervise undergraduate and graduate students and teach in the following postgraduate modules:

Health Statistics (HSC8036) - deputy module lead

Research Skills and Principles for the Biosciences (MMB8100 / MMB8101) - lecturer

Clinical Trials (MCR8015) - module lead

Ethics and Research Governance - Dissertation (HSC8099 / HSC8096) - lecturer

• Articles

  • Gumber L, Agbeleye O, Inskip A, Fairbairn R, Still M, Ouma L, Lozano-Kuehne J, Bardgett M, Isaacs JD, Wason JM, Craig D, Pratt AG. Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions. BMJ Open 2024, 14(4), e077132.
  • Cunnea P, Curry E, Christie E, Nixon K, Kwok CH, Pandey A, Wulandari R, Thol K, Ploski J, Morera-Albert C, McQuaid S, Lozano-Kuehne J, Clark JJ, Krell J, Stronach E, McNeish I, Bowtell D, Fotopoulou C. Spatial and temporal intra-tumoural heterogeneity in advanced High-Grade Serous Ovarian Cancer: implications for surgical and clinical outcomes. Cell Reports Medicine 2023, 4(6), 101055.
  • Aravind P, Popat S, Barwick TD, Soneji N, Lythgoe M, Sreter KB, Lozano-Kuehne JP, Bergqvist M, Patel N, Aboagye EO, Kenny LM. A subset of non-small cell lung cancer patients treated with Pemetrexed show ¹⁸F-Fluorothymidine “Flare” on Positron Emission Tomography. Cancers 2023, 15(14), 3718.
  • Coombes RC, Badman P, Lozano-Kuehne JP, Macpherson IRJ, Zubairi I, Baird RD, Garcia-Corbacho J, Cresti N, Plummer R, Armstrong AC, Allerton R, Landers D, McLellan L, Lim A, Mouliere F, Seckl M. Results of the Phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer. Nature Communications 2022, 13, 3246.
  • Braga A, Paiva G, Ghorani E, Freitas F, Velarde LGC, Kaur B, Unsworth N, Lozano-Kuehne J, Esteves APVS, Filho JR, Junior JA, Aguiar X, Sarwar N, Elias KM, Horowitz NS, Berkowitz RS, Seckl MJ. Predictors for single-agent resistance in FIGO score 5 or 6 gestational trophoblastic neoplasia: an international, multicentre, retrospective study. Lancet Oncology 2021, 22(8), 1188-1198.
  • Pinato DJ, Kaseb A, Wang Y, Saeed A, Szafron D, Jun T, Dharmapuri S, Naqash AR, Muzaffar M, Navaid M, Khan U, Lee C, Bulumulle A, Yu B, Paul S, Fessas P, Nimkar N, Bettinger D, Hildebrand H, Pressiani T, Abugabal YI, Personeni N, Huang Y-H, Lozano-Kuehne J, Rimassa L, Ang C, Marron TU. Impact of corticosteroid therapy on the outcomes of hepatocellular carcinoma treated with immune checkpoint inhibitor therapy. Journal for Immunotherapy of Cancer 2020, 8(2), e000726.
  • Sharma R, Valls PO, Inglese M, Dubash S, Chen M, Gabra H, Montes A, Challapalli A, Arshad M, Tharakan G, Chambers E, Cole T, Lozano-Kuehne JP, Barwick TD, Aboagye EO. [¹⁸F]Fluciclatide PET as a biomarker of response to combination therapy of pazopanib and paclitaxel in platinum-resistant/refractory ovarian cancer. European Journal of Nuclear Medicine and Molecular Imaging 2020, 47, 1239–1251.
  • Trousil S, Lee P, Edwards RJ, Maslen L, Lozano-Kuehne JP, Ramaswami R, Aboagye EO, Clarke S, Liddle C, Sharma R. Altered cytochrome 2E1 and 3A P450‐dependent drug metabolism in advanced ovarian cancer correlates to tumour‐associated inflammation. British Journal of Pharmacology 2019, 176(18), 3712-3722.
  • Sharma R, Valls PO, Inglese M, Dubash S, Chen M, Gabra H, Montes A, Challapalli A, Arshad M, Thakaran G, Chambers E, Cole T, Lozano-Kuehne J, Barwick TD, Aboagye EO. [¹⁸F]Fluciclatide PET As A Biomarker Of Response To Combination Therapy Of Pazopanib And Paclitaxel In Platinum-resistant/refractory Ovarian Cancer. European Journal of Nuclear Medicine and Molecular Imaging 2019, 47(5), 1239-1251.
  • Sharma R, Valls PO, Inglese M, Dubash SR, Chen M, Gabra H, Montes A, Challapalli A, Tharakan G, Chambers E, Cole T, Lozano-Kuehne J, Barwick T, Aboagye E. [¹⁸F] Fluciclatide PET as a biomarker of clinical response to combination therapy of pazopanib and paclitaxel in patients with platinum-resistant or platinum-refractory advanced ovarian cancer: Results of a phase Ib study. Journal of Clinical Oncology 2019, 37(15_suppl).
  • Mihaylova B, Schlackow I, Herrington W, Lozano-Kühne J, Kent S, Emberson J, Reith C, Haynes R, Cass A, Craig J, Gray A, Collins R, Landray M, Baigent C. Cost-effectiveness of simvastatin plus ezetimibe for cardiovascular prevention in chronic kidney disease: results of the SHARP trial. American Journal of Kidney Diseases 2016, 67(4), 576-584.
  • Kent S, Schlackow I, Lozano-Kühne J, Reith C, Emberson J, Haynes R, Gray A, Cass A, Baigent C, Landray MJ, Herrington W, Mihaylova B. What is the impact of chronic kidney disease stage and cardiovascular disease on the annual cost of hospital care in moderate-to-severe kidney disease?. BMC Nephrology 2015, 16, 65.
  • Gabud RS, Aguila MER, Manalang Jr GF, Chua RB, Mendoza ER, Lozano-Kühne JP. An assessment of chronotype and social jet lag among Filipinos. International Journal of Philippine Science and Technology 2015, 8(1), 31-40.
  • Baclig MO, Lozano-Kühne JP, Mapua CA, Gopez-Cervantes J, Natividad FF. Genetic Variation I148M in Patatin-Like Phospholipase 3 Gene and Risk of Non-Alcoholic Fatty Liver Disease Among Filipinos. International Journal of Clinical and Experimental Medicine 2014, 7(8), 2129-2136.
  • Lozano-Kühne JP, Aguila MER, Manalang Jr GF, Chua RB, Gabud RS, Mendoza ER. Shift work research in the Philippines: current state and future directions. Philippine Science Letters 2012, 5(1), 17-29.
  • Baclig MO, Alvarez MR, Lozada XMR, Mapua CA, Lozano-Kühne JP, Dimamay MPS, Natividad FF, Gopez-Cervantes J, Matias RR. Association of glutathione S-transferase T1 and M1 genotypes with chronic liver diseases among Filipinos. International Journal of Molecular Epidemiology and Genetics 2012, 3(2), 153-159.
  • Baclig MO, Predicala RZ, Mapua CA, Lozano-Kühne JP, Daroy MLG, Natividad FF, Javier FO. Allelic and genotype frequencies of catechol-Omethyltransferase (Val158Met) and CYP2D6*10 (Pro34Ser) single nucleotide polymorphisms in the Philippines. International Journal of Molecular Epidemiology and Genetics 2012, 3(2), 115-121.
  • Elsner L, Flügge PF, Lozano J, Muppala V, Eiz-Vesper B, Demiroglu SY, Malzahn D, Herrmann T, Brunner E, Bickeböller H, Multhoff G, Walter L, Dressel R. The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells. Journal of Cellular and Molecular Medicine 2010, 14(4), 992-1002.
  • Malzahn D, Balavarca Y, Lozano JP, Bickeböller H. Tests for candidate gene interaction for longitudinal quantitative traits measured in a large cohort. BMC Proceedings 2009, 3, S80.
  • Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeböller H, Brunner E, Zientkowska M, Herrmann T, Walter L, Alves F, Multhoff G, Dressel R. The heat shock protein HSP70 promotes mouse NK cell activity against tumors which express inducible NKG2D ligands. Journal of Immunology 2007, 179(8), 5523-5533.
  • Bickeböller H, Goddard KAB, Igo RP, Kraft P, Lozano JP, Prankratz N. Issues in association mapping with high-density SNP data and diverse family structures. Genetic Epidemiology 2007, 31(S1), S22-S33.
  • Guazon JLB, Lozano JP, Posas FEB, Calleja HB. Chest radiograph aortic arch calcification is a surrogate marker of coronary artery disease. The Leading Edge in Cardiology 2004.

• Authored Books

  • Lozano JP. Generalized Quantitative Transmission Disequilibrium Test for Analyzing Genetic Main Effects and Epistasis. Göttingen, Germany: Cuvillier Verlag Göttingen, 2010.
  • Mendoza OM, Borja MP, Sevilla TL, Ancheta CA, Saniel OP, Sarol Jr JN, Lozano JP. Foundations of Statistical Analysis for the Health Science. Philippines: Buencamino Press, 2010.

• Book Chapters

  • Lozano-Kühne J. SNPedia. In: Dubitzky W, Wolkenhauer O, Yokota H, Cho K-H, ed. Encyclopedia of Systems Biology. Springer New York LLC, 2013.
  • Lozano-Kühne J. Disease Databases. In: Dubitzky W, Wolkenhauer O, Yokota H, Cho K-H, ed. Encyclopedia of Systems Biology. Springer New York LLC, 2013.
  • Lozano-Kühne J. Cancer Resources. In: Dubitzky W, Wolkenhauer O, Yokota H, Cho K-H, ed. Encyclopedia of Systems Biology. New York: Springer, 2013.

• Conference Proceedings (inc. Abstracts)

  • Lythgoe M, Dama P, Frampton AE, Pickford E, Tookman L, Cunnea P, Fotopoulou C, Liu D, Clark J, Lozano-kuehne J, Badman PD, Clarke A, Chetal S, Fyvie G, Stevenson A, Krell J. Immune modulation and the oral live biotherapeutic product, MRx0518, in treatment-naïve patients with cancer: Updated safety data. 2023, American Society of Clinical Oncology.
  • Kenny LM, Gilbert FJ, Gopalakrishnan G, Aravind P, Barwick T, Patel N, Hiscock DR, Boros I, Kealey S, Aigbirhio FI, Lozano-Kuehne J, Cleator SJ, Fleming B, Riddle P, Ahmad R, Chua S, Johnston SRD, Mansi J, Cook GJ, Aboagye EO. The HERPET study: Imaging HER2 expression in breast cancer with the novel PET tracer [¹⁸F]GE-226, a first-in-patient study. In: ASCO Annual Meeting. 2022, Chicago, IL, USA: American Society of Clinical Oncology.
  • Aravind P, Popat S, Barwick TD, Soneji N, Lythgoe M, Lozano-Kuehne J, Sreter KB, Bergqvist M, Patel NH, Aboagye EO, Kenny LM. [18F]Fluorothymidine(FLT)-PET imaging of thymidine kinase 1 pharmacodynamics in non-small cell lung cancer treated with pemetrexed. In: ASCO Annual Meeting. 2022, Chicago, IL, USA: American Society of Clinical Oncology.
  • Lozano J. Generalized Method in Candidate Gene Analysis for Nonnormally Distributed Quantitative Traits using Family Trios. In: Nineteenth Annual Meeting of the International Genetic Epidemiology Society. 2010, Boston, MA, USA: John Wiley & Sons, Inc.
  • Lozano JP. A generalized method for analyzing genetic main effects and epistasis among candidate genes using parent-offspring trios. In: 18th Annual Meeting of the Belgian Statistical Society. 2010, Spa, Belgium.

• Note

  • Coombes RC, Badman PD, Lozano-Kuehne JP, Liu X, Macpherson IR, Zubairi I, Baird RD, Rosenfeld N, Garcia-Corbacho J, Cresti N, Plummer R, Armstrong A, Allerton R, Landers D, Nicholas H, McLellan L, Lim A, Mouliere F, Pardo OE, Ferguson V, Seckl MJ. Author Correction: Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer (Nature Communications, (2022), 13, 1, (3246), 10.1038/s41467-022-30666-0). Nature Communications 2023, 14(1), 260.