Staff Profile

Following PhD completion as an MRC Clinical Research Training Fellow with Kevin Docherty exploring gene and cell replacement therapy for diabetes, a Glaxo-Smith-Kline Senior Fellowship enabled me to move to Newcastle and join the world-acclaimed diabetes team there. 

In addition to setting up a translational research laboratory I developed a regional complex Type 1 diabetes service focused on specialist hypoglycaemia management incorporating pump therapy and continuous glucose monitoring. I established a supra-regional islet transplant service truly integrated with the solid organ pancreas transplant programme. 

I am Chief Investigator for the multicentre Diabetes UK-funded HypoCOMPaSS RCT comparing optimised insulin analogue with pump therapy and conventional with continuous glucose monitoring in Type 1 diabetes complicated by impaired awareness of hypoglycaemia.  I led the successful United Kingdom Islet Transplant Consortium bid for dedicated NHS funding of this intervention as an established clinical procedure in 2008. This underpinned a further multicentre Diabetes UK grant to prospectively evaluate biomedical / psychosocial outcomes in all UK islet recipients; and enabled participation in the only international RCT in islet transplantation, evaluating the potential of a novel anti-inflammatory agent to maximise engrafted islet mass post-transplantation. I am clinical lead for a burgeoning exercise in Type 1 diabetes research programme in collaboration with Dr Dan West.

My laboratory group is exploring mechanisms underlying loss of beta-cell mass and function in diabetes in addition to further innovations in islet transplantation. As Director of the Transplant Regenerative Medicine Laboratories, I established the Newcastle Islet Isolation and Innovation Hub providing research tissue processing and human islet isolation. Potentially reversible beta-cell dedifferentiation as a common mechanism underlying beta-cell dysfunction in Type 1, Type 2 and cystic fibrosis-related diabetes in addition to post-transplantation is becoming a major focus, facilitated by recent funding from the CF Trust enabling me to establish two international collaborative Strategic Research Centre consortia.

I am Newcastle lead for an MRC-funded initiative to extend the Quality and Safety in Organ Donation Biobank led by Prof Rutger Ploeg in Oxford, to include pancreas, islets hearts and lungs. Through the Newcastle MRC Molecular Pathology Node, this will provide a unique platform for molecular phenotyping across a range of organs linked to clinical data and a circulating biomarker proteomic core. 

I am co-Director of the Newcastle University Translational and Clinical Research Institute, Regenerative Medicine, Stem Cells and Transplantation Theme. I am also Newcastle University Chief Investigator for the Northern Alliance Advanced Therapies Treatment Centre, one of three Innovate UK-funded centres with the goal of accelerating trials and clinical adoption of cell and gene therapies.

I previously co-edited the international textbook ‘Islet transplantation and beta-cell replacement therapy’ with James Shapiro and am editor for the Type 1 diabetes section of the Oxford Textbook of Endocrinology and Diabetes.

Research Interests

Major interests in the development of gene therapy and beta cell replacement for diabetes including stem cell approaches; pancreatic/islet transplantation; and pump therapy by continuous subcutaneous insulin infusion.

Esteem Indicators

Funding

• Dyson NJ, Kattner N, Honkanen-Scott M, Hunter B, Doyle JA, White K, Davey TS, Ploeg RJ, Bury YA, Tiniakos DG, Shaw JAM, Scott WE. Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets. Transplantation Direct 2022, 8(1), e1271.
• Taylor GS, Shaw A, Scragg JH, Smith K, Campbell MD, Macdonald TJ, Shaw JAM, Ross MD, West DJ. Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation. Frontiers in Endocrinology: Clinical Diabetes 2022, 13, 797438.
• Counter C, Sinha S, Muthusamy A, Drage M, Callaghan C, Elker D, Harper S, Sutherland A, Van Dellen D, Johnson P, Manas D, Shaw J, Wilson C, Forsythe J, Hughes S, Casey J, White S. 105.2: Pancreas and Islet Transplantation in the UK During the COVID-19 Era. Transplantation 2021, 105(12S1), S2-S2.
• Nielsen BU, Faurholt-Jepsen D, Oturai PS, Qvist T, Krogh-Madsen R, Katzenstein TL, Shaw J, Ritz C, Pressler T, Almdal TP, Mathiesen IHM. Associations between glucose tolerance, insulin secretion, muscle and fat mass in cystic fibrosis. Clinical Medicine Insights: Endocrinology Diabetes 2021, 14, 1-7.
• Sabbah S, Liew A, Brooks AM, Kundu R, Reading JL, Flatt A, Counter C, Choudhary P, Forbes S, Rosenthal MJ, Rutter MK, Cairns S, Johnson P, Casey J, Peakman M, Shaw J, Tree TIM. Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function. American Journal of Transplantation 2021, 21(3), 1027-1038.
• Masi AC, Oppong YEA, Haugk B, Lamb CA, Sharp L, Shaw JM, Stewart CJ, Oppong KW. Endoscopic ultrasound (EUS) guided fine needle biopsy (FNB) formalin preserved paraffin embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis. Gut 2021, 70(5), 999-1001.
• Izsak V, Soos A, Szakacs Z, Hegyi P, Varannai O, Martonosi AR, Juhasz FM, Foldi M, Kozma A, Vajda Z, Shaw JAM, Parniczky A. Evaluation of currently available screening methods for cystic fibrosis-related diabetes. Pancreatology 2021, 21(1), S53.
• Zummo FP, Krishnanda SI, Georgiou M, O'Harte FPM, Parthsarathy V, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis. Autophagy 2022, 18(4), 799-815.
• Stocker R, Shaw JA, Taylor GS, Witham MD, West DJ. EXercise to Prevent frailty and Loss Of independence in insulin treated older people with DiabetEs (EXPLODE): protocol for a feasibility randomised controlled trial (RCT). BMJ Open 2021, 11, e048932.
• Dyson N, Kattner N, Carey S, Honkanen-Scott M, Hunter B, Davey T, Shaw JA, Scott WE. P.112: Ultrastructural Assessment of the Associations of Obesity and Established Diabetes in Human Pancreata. In: 18th World Congress of the International Pancreas and Islet Transplantation Association (IPITA 2021). 2021, Virtual: Lippincott Williams & Wilkins.
• Owen R, Kurian TA, Carr HJ, Counter C, Thompson EJ, Shaw J, Wilson CH, White SA. P.137: Multi-centre UK Analysis After SPK in Recipients With Type 2 Diabetes Mellitus. In: 18th World Congress of the International Pancreas and Islet Transplantation Association (IPITA 2021). 2021, Virtual: Lippincott Williams & Wilkins.
• Flatt AJS, Greenbaum CJ, Shaw JAM, Rickels MR. Pancreatic islet reserve in type 1 diabetes. Annals of the New York Academy of Sciences 2021, 1495(1), 40-54.
• Al-Mrabeh A, Hollingsworth KG, Shaw JAM, McConnachie A, Sattar N, Lean MEJ, Taylor R. Remission of type 2 diabetes over 2 years restores normal pancreas morphology: post-hoc study. 2021. In Preparation.
• Krentz NAJ, Shea LD, Huising MO, Shaw JAM. Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering. Lancet Diabetes Endocrinol 2021, 9(10), 708-724.
• Izsak VD, Soos A, Szakacs Z, Hegyi P, Juhasz MF, Varannai O, Martonosi AR, Foldi M, Kozma A, Vajda Z, Shaw JAM, Parniczky A. Screening Methods for Diagnosing Cystic Fibrosis-Related Diabetes: A Network Meta-Analysis of Diagnostic Accuracy Studies. Biomolecules 2021, 11(4), 520.
• Forbes S, Flatt AJ, Bennett D, Crookston R, Pimkova M, Birtles L, Pernet A, Wood RC, Burling K, Barker P, Counter C, Lumb A, Choudhary P, Rutter MK, Rosenthal M, Sutherland A, Casey J, Johnson P, Shaw JAM. The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program. American Journal of Transplantation 2021, 10(16), 3653.
• Taylor GS, Shaw A, Smith K, Capper TE, Scragg JH, Cronin M, Bashir A, Flatt A, Campbell MD, Stevenson EJ, Shaw JA, Ross M, West DJ. Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated. Scientific Reports 2021, 11(1), 14502.
• Al-Selwi Y, Shaw JAM, Kattner N. Understanding the Pancreatic Islet Microenvironment in Cystic Fibrosis and the Extrinsic Pathways Leading to Cystic Fibrosis Related Diabetes. Clinical Medicine Insights: Endocrinology and Diabetes 2021, 14, 1-7.
• Piemonti L, Andres A, Casey J, de Koning E, Engelse M, Hilbrands R, Johnson P, Keymeulen B, Kerr-Conte J, Korsgren O, Lehmann R, Lundgren T, Maffi P, Pattou F, Saudek F, Shaw J, Scholz H, White S, Berney T. US food and drug administration (FDA) panel endorses islet cell treatment for type 1 diabetes: A pyrrhic victory?. Transplant International 2021, 34(7), 1182-1186.
• Al-Mrabeh A, Hollingsworth KG, Shaw JAM, McConnachie A, Sattar N, Lean MEJ, Taylor R. 2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial. The Lancet: Diabetes & Endocrinology 2020, 8(12), 939-948.
• Al-Mrabeh A, Hollingsworth KG, Shaw JAM, McConnachie A, Sattar N, Lean MEJ, Taylor R. 2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial. The Lancet Diabetes and Endocrinology 2020, 8(12), 939-948.
• Taylor GS, Moser O, Smith K, Shaw A, Tang JCY, Fraser WD, Eckstein ML, Aziz F, Stevenson EJ, Shaw JA, West DJ. Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case-control study. BMJ Open Diabetes Research and Care 2020, 8(2), e001779.
• Kattner N, Dyson N, Bury Y, Tiniakos D, White K, Davey T, Eliasson L, Tindale L, Wagner B, Honkanen-Scott MM, Doyle J, Ploeg RJ, Shaw JAM, Scott III WE. Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas. Journal of Pathology: Clinical Research 2020, 7(2), 173-187.
• Shapey IM, Summers A, Yiannoullou P, Khambalia H, Fullwood C, Hanley NA, Casey J, Forbes S, Rosenthal M, Johnson PRV, Choudhary P, Bushnell J, Shaw JAM, Augustine T, Rutter MK, van Dellen D. Donor insulin use predicts beta-cell function after islet transplantation. Diabetes, Obesity and Metabolism 2020, 22(10), 1874-1879.
• DeBuitleir C, OConnor E, Satti MM, Shaw JAM, Liew A. Efficacy and safety of a sodium-glucose co-transporter-2 inhibitor versus placebo as an add-on therapy for people with type 2 diabetes inadequately treated with metformin and a dipeptidyl peptidase-4 inhibitor: a systematic review and meta-analysis of randomised controlled trials. Diabetic Medicine 2020, 38(2), e14409.
• White MG, Maheshwari RR, Anderson SJ, Berlinguer-Palmini R, Jones C, Richardson SJ, Rotti PG, Armour SL, Ding Y, Krasnogor N, Engelhardt JF, Gray MA, Morgan NG, Shaw JAM. In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas. Journal of Clinical Endocrinology and Metabolism 2020, 105(5), 1366-1374.
• Taylor GS, Smith K, Capper TE, Scragg JH, Bashir A, Flatt A, Stevenson EJ, McDonald TJ, Oram RA, Shaw JA, West DJ. Postexercise Glycemic Control in Type 1 Diabetes Is Associated With Residual β-Cell Function. Diabetes Care 2020, 43(10), 2362-2370.
• Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, MacDonald P, Shaw JAM, White MG. Reduced expression of the co-regulator TLE1 in type 2 diabetes is associated with increased islet α-cell number. Endocrinology 2020, 161(4), bqaa011.
• Maffi P, Lundgren T, Tufveson G, Rafael E, Shaw JAM, Liew A, Saudek F, Witkowski P, Golab K, Bertuzzi F, Gustafsson B, Daffonchio L, Ruffini PA, Piemonti L, Nano R, Mercalli A, Lampasona V, Magistretti P, Sordi V, Antonio S, Antonioli B, Galuzzi M, Tosca MC, De Carlis L, Colussi G, Korsgren O, Pollard H. Targeting CXCR1/2 does not improve insulin secretion after pancreatic islet transplantation: A phase 3, double-blind, randomized, placebo-controlled trial in type 1 diabetes. Diabetes Care 2020, 43(4), 710-718.
• Speight J, Holmes-Truscott E, Harsimran S, Little SA, Shaw JAM. Development and psychometric validation of the novel Glucose Monitoring Experiences Questionnaire (GME-Q) among adults with type 1 diabetes. Diabetes Technology & Therapeutics 2019, 21(12), 691-701.
• Kelly AC, Smith KE, Purvis WG, Min CG, Weber CS, Cooksey AM, Hasilo C, Paraskevas S, Suszynski TM, Weegman BP, Anderson MJ, Camacho LE, Harland RC, Loudovaris T, Jandova J, Molano DS, Price ND, Georgiev IG, Scott WE, Manas DMD, Shaw JAM, O'Gorman D, Kin T, McCarthy FM, Szot GL, Posselt AM, Stock PG, Karatzas T, Shapiro AMJ, Lynch RM, Limesand SW, Papas KK. Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling. Transplantation 2019, 103(1), 160-167.
• Flatt AJS, Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Lubina-Solomon A, Holmes-Truscott E, Chadwick TJ, Wood R, McDonald TJ, Kerr D, Flanagan D, Brooks A, Heller SR, Evans ML, Shaw JAM. Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study. Diabetes Care 2019, 42(10), 1-9.
• Speight J, Holmes-Truscott E, Little SA, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial. Diabetes Technology & Therapeutics 2019, 21(11), 619-626.
• Khan D, Kelsey R, Maheshwari RR, Stone VM, Hasib A, Manderson Koivula FN, Watson A, Harkin S, Irwin N, Shaw JA, McClenaghan NH, Venglovecz V, Ebert A, Flodstrom-Tullberg M, White MG, Kelly C. Short-term CFTR inhibition reduces islet area in C57BL/6 mice. Scientific Reports 2019, 9(1), 11244.
• Flatt AJS, Bennett D, Counter C, Brown AL, White SA, Shaw JAM. β-Cell and renal transplantation options for diabetes. Diabetic Medicine 2019, 37(4), 580-592.
• Rickels MR, Stock PG, De Koning EJP, Piemonti L, Pratschke J, Alejandro R, Bellin MD, Berney T, Choudhary P, Johnson PR, Kandaswamy R, Kay TWH, Keymeulen B, Kudva YC, Latres E, Langer RM, Lehmann R, Ludwig B, Markmann JF, Marinac M, Odorico JS, Pattou F, Senior PA, Shaw JAM, Vantyghem M-C, White S. Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria from the IPITA/EPITA Opinion Leaders Workshop. Transplantation 2018, 102(9), 1479-1486.
• Al-Jahdhami NA, Anderson SJ, Aldibbiat A, Shaw JA. Improved Beta-Cell Differentiation and Function in Isolated Islets Established in Dynamic Culture to Reduce Hypoxia. In: 78th American Diabetes Association Scientific Sessions. 2018, Orlando, FL: American Diabetes Association.
• Anderson SJ, White MG, Armour SL, Maheshwari R, Tiniakos D, Muller YD, Berishvili E, Berney T, Shaw JAM. Loss of end-differentiated β-cell phenotype following pancreatic islet transplantation. American Journal of Transplantation 2018, 18(3), 750-755.
• Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Lubina-Solomon A, Chadwick TJ, Stocken DD, Brennand C, Marshall SM, Wood R, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Sustained reduction in severe hypoglycemia in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: 2-year follow-up in the HypoCOMPaSS randomized clinical trial. Diabetes Care 2018, 41(8), 1600-1607.
• Carter V, Howell WM, Shaw JAM. Donor-Specific Antibodies - The Devil Is in the Detail. American Journal of Transplantation 2017, 17(7), 1959-1959.
• Zummo FP, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Glucagon-like peptide-1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function. Diabetes 2017, 66(5), 1272-1285.
• Stewart CJ, Nelson A, Campbell MD, Walker M, Stevenson EJ, Shaw JA, Cummings SP, West DJ. Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study. Diabetic Medicine 2017, 34(1), 127-134.
• Niessen SJM, Hazuchova K, Powney SL, Guitian J, Niessen APM, Pion PD, Shaw JA, Church DB. The big pet diabetes survey: Perceived frequency and triggers for euthanasia. Veterinary Sciences 2017, 4(2), 27.
• Armour SL, Anderson SJ, Shaw JAM, White MG. A Novel Role for Tle3 in Maintaining Beta Cell Identity. In: 76th Scientific Sessions. 2016, New Orleans: American Diabetes Association.
• Popov AA, Montalbano G, Scott WE, Chen J, Shaw JAM, Dalgarno K, Ferreira-Duarte AM. 3D manufactured islet micro-tissues for the treatment of type-1 diabetes. In: TERMIS-EU 2016 Conference. 2016, Uppsala, Sweden: eCM.
• Campbell MD, Walker M, King D, Allerton D, Shaw JA, Luzio S, Dunseath G, Bracken RM, Stevenson EJ, West DJ. Administering a small rapid-acting insulin bolus 3 h after eating a mixed macronutrient meal improves postprandial glucose control, without hypoglycaemia, in people with Type 1 diabetes. In: Diabetes UK Professional Conference 2016. 2016, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Campbell MD, Walker M, King D, Gonzalez JT, Allerton D, Stevenson EJ, Shaw JA, West DJ. Carbohydrate counting at meal time followed by a small secondary postprandial bolus injection at 3 hours prevents late hyperglycemia, without hypoglycemia, after a high-carbohydrate high-fat meal in Type 1 diabetes. Diabetes Care 2016, 39(9), e141-e142.
• Speight J, Barendse SM, Singh H, Little SA, Inkster B, Frier BM, Heller SR, Rutter MK, Shaw JAM. Characterizing problematic hypoglycaemia: iterative design and preliminary psychometric validation of the Hypoglycaemia Awareness Questionnaire (HypoA-Q). Diabetic Medicine 2016, 33(3), 376-385.
• Logue JA, Scott WE, Honkanen-Scott M, De Haviland J, Abou-Saleh A, Manas DM, Shaw JAM, Dickinson A, Gabre H, Dennison AR, Charnley RM, White SA. Diversifying the Indications for Pancreas Resection and Autologous Islet Cell Transplantation (IAT) in both Adults and Children. In: Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, 19th Annual Scientific Meeting. 2016, Leeds: John Wiley & Sons, Ltd.
• Anderson SJ, Armour SL, White MG, Berishvili E, Berney T, Shaw JAM. Evidence for Beta Cell Dedifferentiation as a Cause for Sustained Graft Dysfunction Following Peri Engraftment Hypoxia in Clinical Islet Transplantation. In: American Diabetes Association 76th Scientific Sessions. 2016, New Orleans: American Diabetes Association.
• Logue JA, Scott WE, Honkanen-Scott M, De Haviland J, Abou-Saleh A, Gabre H, Manas DM, Shaw JAM, Dickinson A, Dennison AR, Charnley RM, White SA. Expanding the indications for pancreas resection and autologous islet cell transplantation (IAT) in both adults and children. In: Society of Academic and Research Surgery 2016 Annual Meeting. 2016, London: John Wiley & Sons Ltd.
• Liew A, Bhattacharya V, Shaw J, Stansby G. Gene therapy for peripheral arterial disease (Protocol). Cochrane Database of Systematic Reviews 2016, (1), CD012058.
• Zummo FP, Cullen KS, Lovat PE, Shaw JA, Arden C. Glucagon-like peptide-1 requires EPAC activity to restore autophagy and protect pancreatic beta cells from cell death. In: Diabetes UK Professional Conference 2016. 2016, Glasgow: Wiley-Blackwell.
• Anderson SJ, Marshall H, Shaw JAM. Hypoxia-induced beta cell dedifferentiation: the missing link in islet transplant dysfunction?. In: Diabetes UK Professional Conference 2016. 2016, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
• Armour SL, Shaw JA, White MG. Limitation of glucotoxicity-induced beta-cell dedifferentiation and alpha-cell transition following Nkx6.1 overexpression. In: Diabetes UK Professional Conference. 2016, Glasgow: Wiley-Blackwell.
• Tan HK, Little SA, Leelarathna L, Walkinshaw E, Lubina-Solomon A, Hosking J, Speight J, Kerr D, Heller SR, Evans ML, Shaw JAM, Flanagan D. Low-blood glucose avoidance training improves glycemic variability in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: HypoCOMPaSS trial. Diabetes Care 2016, 39(4), e56-e58.
• Ye J, Bulwer C, Amin R, Dayan CM, Marshall H, Shaw JA, Williams AJK, Gillespie KM. Methylation specific cell free DNA to monitor islet autoimmunity in Type 1 diabetes. In: Diabetes UK Professional Conference 2016. 2016, Glasgow, UK: Wiley-Blackwell.
• Ye J, Bulwer C, Amin R, Dayan CM, Marshall H, Shaw JA, Williams AJK, Gillespie KM. Methylation specific cell free DNA to monitor islet autoimmunity in Type 1 diabetes. In: Diabetes UK Professional Conference. 2016, Glasgow: Wiley-Blackwell Publishing Ltd.
• Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Recovery of hypoglycemia awareness in longstanding type 1 diabetes: A multicenter 2×2 factorial randomized controlled trial comparing insulin pump with multiple daily injections and continuous with conventional glucose selfmonitoring (HypoCOMPaSS). Diabetes Technology and Therapeutics 2016, 18(Suppl. 1), S27-S28.
• White MG, Shaw JAM, Taylor R. Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction. Diabetes Care 2016, 39(11), 2080-2088.
• Brooks AM, Carter V, Liew A, Marshall H, Aldibbiat A, Sheerin NS, Manas DM, White SA, Shaw JA. De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes. American Journal of Transplantation 2015.
• Campbell MD, Walker M, Trenell MI, Stevenson EJ, Shaw JA, Luzio S, Dunseath GJ, West DJ. A combined basal-bolus insulin dose reduction strategy for preventing exercise-induced hypoglycaemia does not cause hormonal, metabolic or inflammatory disturbances in Type 1 diabetes. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Campbell MD, Walker M, Trenell MI, Stevenson EJ, Shaw JA, Bracken RM, Turner D, Gray BJ, West DJ. A novel strategy that prevents early- and late-onset nocturnal hypoglycaemia following evening exercise in Type 1 diabetes. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell.
• Zummo FP, Cullen KS, Lovat PE, Shaw JA, Arden C. An emerging role for autophagy in the regulation of beta cell survival by glucagon-like peptide-1. In: 51st EASD Annual Meeting. 2015, Stockholm, Sweden: Springer.
• Armour SL, Shaw JA, White MG. An in vitro model of beta cell de-differentiation and potential alpha cell reprogramming. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Speight J, Singh H, Little SA, Flanagan D, Kerr D, Evans ML, Heller SR, Shaw JA. Associations with hyperglycaemia avoidance among adults with long-standing Type 1 diabetes and impaired awareness of hypoglycaemia: baseline characteristics from the HypoCOMPaSS Study. In: Diabetes UK Professional Conference 2015. 2015, London, UK: WILEY-BLACKWELL.
• Walkinshaw E, Little SA, Bernjak A, Lubina-Solomon A, Chow E, Shaw JAM, Heller SR. Cardiac autonomic regulation during experimental hypoglycaemia in type 1 diabetes with impaired awareness of hypoglycaemia. In: 51st EASD Annual Meeting. 2015, Stockholm, Sweden: Springer.
• Walkinshaw E, Little SA, Bernjak A, Lubina-Solomon A, Chow E, Shaw JA, Heller SR. Cardiac autonomic regulation during experimental hypoglycaemia in Type 1 diabetes with impaired awareness of hypoglycaemia (IAH). In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell.
• Liew A, Bhattacharya V, Shaw J, Stansby G. Cell Therapy for Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. Angiology 2015, 1-12.
• Campbell MD, Gonzalez JT, Rumbold PL, Walker M, Shaw JA, Stevenson EJ, West DJ. Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes. American Journal of Clinical Nutrition 2015, 101(3), 478-486.
• Anderson SJ, White MG, Marshall HL, Shaw JA. Contaminating exocrine tissue as a source of MCP-1 in islet transplantation. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell.
• Brooks AM, Oram R, Home P, Steen N, Shaw JAM. Demonstration of an Intrinsic Relationship Between Endogenous C-Peptide Concentration and Determinants of Glycemic Control in Type 1 Diabetes Following Islet Transplantation. Diabetes Care 2015, 38(1), 105-112.
• Scott W, Honkanen-Scott MM, De Havilland J, Logue J, Abou-Saleh A, Gabra H, Charnley R, Shaw JAM, White SA. Expanding the indications for paediatric and adult autologous islet transplantation. In: IPITA-IXA-CTS 2015 Joint Congress. 2015, Melbourne, Australia: Wiley-Blackwell.
• Zummo FP, Cullen KS, Lovat PE, Shaw JA, Arden C. Glucagon-like peptide 1 protects pancreatic beta cells from programmed cell death: a role for autophagy. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Tan HK, Little SA, Leelarathna L, Walkinshaw E, Lubina-Solomon A, Kerr D, Heller SR, Evans ML, Shaw JA, Flanagan D, Speight J. Hypoglycaemia avoidance training improves glucose variability in Type 1 diabetes (HypoCOMPaSS Study). In: Diabetes UK Professional Conference 2015. 2015, London, UK: Wiley-Blackwell.
• West DJ, Stevenson EJ, Campbell MD, Walker M, Shaw JA, Ahmed FW, Wijaya S, Weaver J. Inflammation and the acute endothelial progenitor cell response to submaximal running exercise in males with and without Type 1 diabetes. In: Diabetes UK Professional Conference 2015. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Campbell MD, Walker M, Bracken RM, Turner D, Stevenson EJ, Gonzalez JT, Shaw JA, West DJ. Insulin therapy and dietary adjustments to normalise glycaemia and prevent nocturnal hypoglycaemia after evening exercise in Type 1 diabetes: a randomized controlled trial. BMJ Open Diabetes Research & Care 2015, 3, e000085.
• White MG, Armour SL, Shaw JA. Limiting human beta cell de-differentiation by small molecule inhibitors of the transforming growth factor beta (TGF-beta) pathway. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell Publishing Ltd.
• Stevenson EJ, Campbell MD, Gonzalez JT, Walker M, Shaw JA, West DJ. Subjective and hormonal appetite responses to high and low glycaemic index post-exercise meals, under matched insulinaemia and fibre in Type 1 diabetes. In: Diabetes UK Professional Conference. 2015, London, UK: Wiley-Blackwell.
• Scott W, De Havilland J, Honkanen-Scott MM, Logue J, Abou-Saleh A, Charnley RM, Manas DM, Shaw JAM, White SA. Successful autologous islet transplantation post-frey's procedure using a side-vented 'therapeutic infusion needle' for improved enzyme delivery. In: IPITA-IXA-CTS Joint Congress. 2015, Melbourne, Australia: Wiley-Blackwell Publishing Ltd.
• West DJ, Campbell MD, Gonzalez JT, Walker M, Stevenson EJ, Ahmed FW, Wijaya S, Shaw JA, Weaver JU. The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study. Cardiovascular Diabetology 2015, 14, 71.
• Hudson A, Bradbury L, Johnson R, Fuggle SV, Shaw JAM, Casey JJ, Friend PJ, Watson CJE. The UK Pancreas Allocation Scheme for Whole Organ and Islet Transplantation. American Journal Of Transplantation 2015, 15(9), 2443-2455.
• Campbell MD, Walker M, Trenell MI, Stevenson EJ, Turner D, Bracken RM, Shaw JA, West DJ. A Low-Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes. Diabetes Care 2014, 37(7), 1845-1853.
• Tan HK, Little SA, Leelarathna L, Walkinshaw E, Lubina-Solomon A, Kerr D, Heller S, Evans ML, Shaw JA, Flanagan D. Coefficient of variation from continuous glucose monitoring is associated with the frequency of hypoglycaemia in Type 1 diabetes complicated by impaired awareness of hypoglycaemia: baseline analysis of the HypoCOMPaSS study group. In: Diabetes UK Professional Conference 2014. 2014, Liverpool, UK: Wiley-Blackwell.
• Harrison M, Marriott C, Shaw J. Examining Glycaemic Control and Variability Utilising the Medtronic Continuous Glucose Monitoring System (CGMS) In Pre And Post CSII Therapy. In: 7th International Conference on Advanced Technologies & Treatments for Diabetes. 2014, Vienna, Austria: Mary Ann Liebert, Inc.
• Oram RA, Brooks AM, Forbes S, Eckoldt S, Smith RM, Choudhary P, Rosenthal MJ, Johnson P, Rutter MK, Burling KA, McDonald TJ, Shaw JAM, Hattersley AT. Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function. Diabetes Care 2014, 37(6), 1737-1740.
• White MG, Shaw JAM. Involvement of Notch signaling in Human Beta-Cell Dedifferentiation. In: American Diabetes Association 74th Scientific Sessions. 2014, San Francisco, CA, USA: Diabetes.
• Reddy MS, Carter N, Cunningham A, Shaw J, Talbot D. Portal Venous Oxygen Persufflation of the Donation after Cardiac Death pancreas in a rat model is superior to static cold storage and hypothermic machine perfusion. Transplant International 2014, 27(6), 634-639.
• Little SA, Leelarathna L, Walkinshaw E, Kai Tan H, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Recovery of Hypoglycemia Awareness in Long-Standing Type 1 diabetes: A Multicenter 2x2 Factorial Randomized Controlled Trial Comparing Insulin Pump with Multiple Daily Injections and Continuous with Conventional Glucose Self-Monitoring (HypoCOMPaSS). Diabetes Care 2014, 37(8), 2114-2122.
• Little SA, Leelarathna L, Walkinshaw E, Tan HK, Chapple O, Lubina-Solomon A, Chadwick TJ, Barendse S, Stocken DD, Brennand C, Marshall SM, Wood R, Speight J, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Response to Comment on Little et al. Recovery of Hypoglycemia Awareness in Long-standing Type 1 Diabetes: A Multicenter 2 x 2 Factorial Randomized Controlled Trial Comparing Insulin Pump With Multiple Daily Injections and Continuous With Conventional Glucose Self-monitoring (HypoCOMPaSS). Diabetes Care 2014;37:2114-2122. Diabetes Care 2014, 37(12), E272-E273.
• Little SA, Leelarathna L, Barendse SM, Walkinshaw E, Tan HK, Solomon AL, de Zoysa N, Rogers H, Choudhary P, Amiel SA, Heller SR, Evans M, Flanagan D, Speight J, Shaw JAM. Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention. Diabetes/Metabolism Research and Reviews 2014, 30(3), 175-190.
• Fairhall EA, Wallace K, White SA, Huang GC, Shaw JA, Wright SC, Charlton KA, Burt AD, Wright MC. Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research. Toxicology Research 2013, 2(1), 80-87.
• Brooks AM, Walker N, Aldibbiat A, Hughes S, Jones G, de Havilland J, Choudhary P, Huang GC, Parrott N, McGowan NWA, Casey J, Mumford L, Barker P, Burling K, Hovorka R, Walker M, Smith RM, Forbes S, Rutter MK, Amiel S, Rosenthal MJ, Johnson P, Shaw JAM. Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations. American Journal of Transplantation 2013, 13(12), 3236-3243.
• White MG, Marshall HL, Shaw JAM. Beta cell dedifferentiation: Evidence for ductal progenitors as a source of new beta cells?. In: Diabetes UK Professional Conference. 2013, Manchester: Wiley-Blackwell Publishing Ltd.
• White MG, Marshall HL, Rigby R, Huang GC, Amer A, Booth T, White S, Shaw JAM. Expression of Mesenchymal and α-Cell Phenotypic Markers in Islet β-Cells in Recently Diagnosed Diabetes. Diabetes Care 2013, 36(11), 3818-3820.
• Mueller KR, Scott WE, Jie T, Weegman BP, Balamurugan AN, Kitzmann JP, Marshall H, Shaw J, Manas D, Persaud S, Huang GC, Khorsandi SE, Tempelman L, Pongratz RL, Cline GW, Gruessner AC, Gruessner RW, Papas K. Human Pancreas Persufflation Ameliorates Hypoxia-Induced Impairment of Islet Function Post-Isolation. In: 14th World Congress of the International Pancreas and Islet Transplant Association. 2013, Monterey, CA, USA: Lippincott Williams & Wilkins.
• Papas KK, Karatzas T, Berney T, Minor T, Pappas P, Pattou F, Shaw J, Toso C, Schuurman HJ. International workshop: islet transplantation without borders enabling islet transplantation in Greece with international collaboration and innovative technology. Clinical Transplantation 2013, 27(2), E116-E125.
• Mumford LL, Shaw JA, Johnson P, Jones G, Parrott N, Rutter MK, Amiel S, Smith RM, McGowan N, Hughes S, Huang GC, Casey J. Islet Activity and Outcomes in the United Kingdom. In: 14th World Congress of the International Pancreas and Islet Transplant Association. 2013, Monterey, CA, USA: Lippincott Williams & Wilkins.
• Forbes S, Shaw JAM. Islet transplantation and return of hypoglycaemic awareness: the same Driver and Vehicle Licensing Agency (DVLA) rules still apply. Diabetic Medicine 2013, 30(7), 886-886.
• Leelarathna L, Little SA, Walkinshaw E, Tan HK, Kumareswaran K, Solomon AL, Flanagan D, Heller S, Shaw JAM, Evans ML, Chow E. Patients with longstanding type 1 diabetes show improved self awareness of hypoglycaemia measured during clamped hypoglycaemic challenges after a six month intensive treatment period in the HypoCOMPASS Study: comparison of optimised multiple daily injections (MDI) and continuous insulin infusion therapy (CSII) with or without adjunctive real-time continuous glucose monitoring (RTCGM). In: Diabetes UK Professional Conference 2013. 2013, Manchester, UK: Wiley-Blackwell Publishing Ltd.
• Ahmmed AA, Brooks AMS, Hollingsworth KG, Trenell M, Choudhary P, Amiel SA, Rosenthal M, Forbes S, Rutter MK, Taylor R, Shaw JAM. Quantification of hepatic steatosis before and after intraportal pancreatic islet transplantation. In: Diabetes UK Professional Conference 2013. 2013, Manchester, UK: Wiley-Blackwell Publishing Ltd.
• Marshall HL, Mueller KR, Papas KK, Shaw JAM. Rapid detection of hypoxic islet stress by oxygen consumption rate using a standardised beta cell model. In: Diabetes UK Professional Conference 2013. 2013, Manchester, UK: Wiley-Blackwell Publishing Ltd.
• Brooks AMS, Aldibbiat A, Bennett D, Wardle J, Gordon C, Walker M, Shaw JAM. Restoration of endogenous C-peptide by islet transplantation is associated with increased duration of normoglycaemia and reduced blood glucose variability in recipients with Type 1 diabetes. In: Diabetes UK Professional Conference 2013. 2013, Manchester, UK: Wiley-Blackwell Publishing Ltd.
• Leelarathna L, Little SA, Walkinshaw E, Tan HK, Lubina-Solomon A, Kumareswaran K, Lane AP, Chadwick T, Marshall SM, Speight J, Flanagan D, Heller SR, Shaw JA, Evans ML. Restoration of self-awareness of hypoglycemia in adults with long-standing Type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial. Diabetes Care 2013, n/a, n/a.
• Oram RA, Brooks AMS, Smith R, Rutter MK, Johnson PR, Choudhary P, Rosenthal M, Forbes S, McDonald TJ, Hattersley AT, Shaw JAM. Urine c-peptide creatinine ratio can be used for home monitoring of islet transplant function. In: Diabetes UK Professional Conference 2013. 2013, Manchester: Wiley-Blackwell Publishing Ltd.
• Little S, Chadwick T, Choudhary P, Brennand C, Stickland J, Barendse S, Olateju T, Leelarathna L, Walkinshaw E, Tan HK, Marshall SM, Thomas RM, Heller S, Evans M, Kerr D, Flanagan D, Speight J, Shaw JAM. Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial). BMC Endocrine Disorders 2012, 12(1), 33.
• Thomas MP, Wilson CH, Nayar M, Manas DM, Walker M, Shaw J, White SA. Endoscopic Botulinum Toxin Injection for the Treatment of Diabetic Gastropathy in Pancreas and Islet-cell Transplant Patients. Experimental and Clinical Transplantation 2012, 10(2), 168-171.
• Niessen SJM, Powney S, Guitian J, Niessen APM, Pion PD, Shaw JAM, Church DB. Evaluation of a Quality-of-Life Tool for Dogs with Diabetes Mellitus. Journal of Veterinary Internal Medicine 2012, 26(4), 953-961.
• Niessen SJM, Fernandez-Fuente M, Mahmoud A, Campbell SC, Aldibbiat A, Huggins C, Brown AE, Holder A, Piercy RJ, Catchpole B, Shaw JAM, Church DB. Novel diabetes mellitus treatment: mature canine insulin production by canine striated muscle through gene therapy. Domestic Animal Endocrinology 2012, 43(1), 16-25.
• Barlow AD, Xie J, Moore CE, Campbell SC, Shaw JA, Nicholson ML, Herbert TP. Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2). Diabetologia 2012, 55(5), 1355-1365.
• Aldibbiat A, Huang GC, Zhao M, Holliman GN, Ferguson L, Hughes S, Brigham K, Wardle J, Williams R, Dickinson A, White SA, Johnson PRV, Manas D, Amiel SA, Shaw JAM. Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England. Cell Transplantation 2012, 21(1), 382-382.
• Little S, Shaw J, Home P. Hypoglycemic rates with basal insulin analogs. Diabetes Technology & Therapeutics 2011, 13(Suppl. 1), S53-S64.
• Choudhary P, Shin J, Wang YY, Evans ML, Hammond PJ, Kerr D, Shaw JAM, Pickup JC, Amiel SA. Insulin Pump Therapy With Automated Insulin Suspension in Response to Hypoglycemia: Reduction in nocturnal hypoglycemia in those at greatest risk. Diabetes Care 2011, 34(9), 2023-2025.
• White MG, Al-Turaifi HR, Holliman GN, Aldibbiat A, Mahmoud A, Shaw JAM. Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas. Journal of Endocrinology 2011, 211(2), 169-176.
• Wallace K, Shaw J, White SA, Wright S, Burt AD, Wright MC. Prolonged glucocorticoid exposure results in the appearance of hepatocytes in the adult pancreas. In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.
• Hammond P, Amiel S, Dayan C, Kerr D, Pickup J, Shaw J, Campbell F, Greene S, Hindmarsh P. ABCD position statement on continuous glucose monitoring: Use of glucose sensing in outpatient clinical diabetes care. Practical Diabetes International 2010, 27(2), 66-68.
• MacKinnon D, Shaw J, Docherty I. Devolution as Process: Institutional Structures, State Personnel and Transport Policy in the United Kingdom. Space and Polity 2010, 14(3), 271-287.
• Shakoor SKA, Aldibbiat A, Ingoe LE, Campbell SC, Sibal L, Shaw J, Home PD, Razvi S, Weaver JU. Endothelial Progenitor Cells in Subclinical Hypothyroidism: The Effect of Thyroid Hormone Replacement Therapy. Journal of Clinical Endocrinology and Metabolism 2010, 95(1), 319-322.
• Cumbers A, MacKinnon D, Shaw J. Labour, organisational rescaling and the politics of production: union renewal in the privatised rail industry. Work, Employment & Society 2010, 24(1), 127-144.
• Ridgway D, Manas D, Shaw J, White S. Preservation of the donor pancreas for whole pancreas and islet transplantation. CLINICAL TRANSPLANTATION 2010, 24(1), 1-19.
• Wallace K, White SA, Shaw JA, Burt AD, Wright MC. Chronic Elevated Systemic Glucocorticocoid Results in Widespread Pancreatic-Hepatic Trans-Differentiation In Vivo. In: The Liver Meeting 2009: 60th Annual Meeting of the American Association for the Study of Liver Diseases. 2009, Boston, Massachusetts: Hepatology: John Wiley & Sons, Inc.
• Sibal L, Aldibbiat A, Agarwal SC, Mitchell G, Oates C, Razvi S, Weaver JU, Shaw JA, Home PD. Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria. Diabetologia 2009, 52(8), 1464-1473.
• Reddy MS, Kibondo A, Aldibbiat A, Stamp S, Shenton B, Shaw JAM, Carter N, Cunningham A, Talbot D. Improved Preservation of Non Heart-Beating- Donor Pancreases Prior to Islet Isolation Using Portal Venous Oxygen Persufflation. American Journal of Transplantation 2009, 9, 405.
• Niessen S, Mahmoud A, Arden C, Brown A, Campbell S, Aldibbiat A, Church D, Shaw J. Muscle targeted gene therapy for diabetes mellitus: role of proteasomal decay in mutant proinsulin plasmid efficiency. In: Human Gene and Cell Therapy: 17th European Society of Gene and Cell Therapy. 2009, Hannover, Germany: Mary Ann Liebert, Inc. Publishers.
• Mahmoud A, Niessen S, Aldibbiat A, Al-Turaifi H, Huggins C , Shaw JAM. Muscle-targeted gene transfer enables continuous secretion of GLP-1 and exendin-4 in mice. Human Gene Therapy 2009, 20(11), 1542.
• White S, Shaw J, Sutherland D. Pancreas transplantation. The Lancet 2009, 373(9677), 1808-1817.
• Reddy M, Kibondo A, Aldibbiat A, Stamp S, Shenton BK, Shaw JAM, Carter N, Cunningham A, Talbot D. Portal venous oxygen persufflation for the preservation of non heart-beating-donor pancreases prior to islet isolation. In: 14th Congress of the European Society for Organ Transplantation. 2009, Paris, France: Transplant International: Wiley-Blackwell.
• Arden C, Hampson L, Huang G, Shaw J, Aldibbiat A, Holliman G, Manas D, Khan S, Lange A, Agius L. A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells. Biochemical Journal 2008, 411(1), 41-51.
• Niessen S, Mahmoud A, Aldibbiat A, Campbell S, Brown A, Huggins C, Catchpole B, Church D, Shaw J. Development of muscle targeted gene therapy with a mutant canine proinsulin plasmid for the treatment of canine diabetes mellitus. In: 16th Annual Congress of the European Society of Gene and Cell Therapy. 2008, Brugge, Belgium: Human Gene Theraphy: Mary Ann Liebert Inc.
• AlTuraifi HRH, Aldibbiat AIM, Holliman GN, Campbell SC, Shaw JAM, Huang GGC, Amiel SGC. Expression of pluripotent stem cell markers within intact adult human pancreas and proliferative adherent cell cultures derived from digested pancreas. Diabetologia 2008, 51(s1), S182 no. 437.
• Al-Turaifi HRH, AldibbiaT AIM, Holliman GN, Campbell SC, Shaw JAM, Huang GGC, Amiel SGC. Expression of pluripotent stem cell markers within intact adult human pancreas and proliferative adherent cell cultures derived from digested pancreas. In: DIABETOLOGIA. 2008, 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.
• Mahmoud A, Aldibbiat A, Niessen SJM, Campbell SC, Holliman GN, Joshi S, Scougall KT, Shaw JAM. Expression, storage and rapid regulated secretion of active glucagon like peptide-1 following muscle-targeted gene transfer. Diabetologia 2008, 51(s1), S363 no. 906.
• Mahmoud A, Aldibbiat A, Niessen SJM, Campbell SC, Holliman GN, Joshi S, Scougall KT, Shaw JAM. Expression, storage and rapid regulated secretion of active glucagon like peptide-1 following muscle-targeted gene transfer. In: DIABETOLOGIA. 2008, 233 SPRING ST, NEW YORK, NY 10013 USA: SPRINGER.
• Aldibbiat A, Holliman GN, Al-Turaifi H, Campbell SC, Huang G, Shaw J. Generation of insulin-synthesising pseudo-islets from adult stem cell cultures derived from the human pancreas. Diabetologia 2008, 51(Supplement 1), S183 no. 439.
• Aldibbiat A, Marriott CE, Scougall KT, Campbell SC, Huang GC, Macfarlane WM, Shaw JAM. Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway. Journal of Endocrinology 2008, 196(1), 33-43.
• Niessen SJM, Mahmoud A, Aldibbiat A, Huggins C, Church DB, Shaw JAM. Muscle-targeted gene therapy for the treatment of diabetes mellitus: Investigating the role of the immune system when employing mutant (pro)insulin. Diabetologia 2008, 51(Supplement 1), S243 no. 600.
• Niessen S, Mahmoud A, Campbell S, Brown A, Aldibbiat A, Huggins C, Church D, Shaw J. Novel furin-cleavable human insulin construct (hppI5) for muscle targeted gene therapy in diabetes mellitus. In: 16th Annual Congress of the European Society of Gene and Cell Therapy. 2008, Brugge, Belgium: Human Gene Therapy: Mary Ann Liebert Inc.
• Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, Butler CS, Shaw JA, Macfarlane WM. Selenium stimulates pancreatic beta-cell gene expression and enhances islet function. FEBS Letters 2008, 582(15), 2333-2337.
• Sibal L, Jones A, Aldibbiat A, Mitchell G, Oates C, Weaver J, Shaw JAM, Home PD. The influence of the presence of retinopathy on the circulating endothelial progenitor cell counts, endothelial function and carotid intima-media thickness in type I diabetes. Diabetologia 2008, 51(Supplement 1), S552 no. 1372.
• Thomas RM, Aldibbiat A, Griffin W, Cox MAA, Leech NJ, Shaw JAM. A randomized pilot study in type 1 diabetes complicated by severe hypoglycaemia, comparing rigorous hypoglycaemia avoidance with insulin analogue therapy, CSII or education alone. Diabetic Medicine 2007, 24(7), 778-783.
• Arden C, Trainer A, De La Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw J, Matschinsky FM, Agius L. Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic β-cells: Evidence for cellular instability of catalytic activity. Diabetes 2007, 56(7), 1773-1782.
• Ratanamart J, Huggins CG, Kirby JA, Shaw J. In vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids. Journal of Gene Medicine 2007, 9(8), 703-714.
• Aldibbiat A, Huang GC, Zhao M, Reddy MS, Holliman GH, Dunn J, Dickinson AM, Manas DM, Amiel SA, Shaw JAM. [abstract] Confirmation of maintained sterility, viability and function in clinical-grade human islets following transport from an approved geographically-distance isolation facility. Diabetic Medicine 2006, 23(s2), 23 abstract no. A86.
• Arden C, Scougall KT, Shaw JAM, Agius L. [abstract] Generation of MIN6 stable cell lines expressing GFP-tagged glucokinase for cellular analysis of glucokinase mutants. Diabetic Medicine 2006, 23(s2), 9 abstract no. A30.
• Sibal L, Aldibbiat A, Harvey IJ, Shenton BK, Holliman GN, Shaw JAM, Home PD. [abstract] Identification and quantification of circulating endothelial progenitor cells in individuals with Type 1 diabetes and non-diabetic controls. Diabetic Medicine 2006, 23(s2), 49 abstract no. P74.
• Arutchelvam V, Heslop E, Welsh P, Griffins W, Weatherburn S, Aldibbiat A, Leech N, Shaw JAM. [abstract] Safety and efficacy of continuous subcutaneous insulin infusion therapy in relation to pre-intervention HbA1c. Diabetic Medicine 2006, 23(s2), 86 abstract no. P222.
• Ratanamart J, Shaw JAM. Plasmid-mediated muscle-targeted gene therapy for circulating therapeutic protein replacement: A tale of the tortoise and the hare?. Current Gene Therapy 2006, 6(1), 93-110.
• Wilson MO, Scougall KT, McIntyre EA, Shaw JAM. Storage, processing and rapid regulated secretion of insulin following gene transfer to human muscle. In: British Society for Gene Therapy: 2nd Annual Meeting. 2006, Manchester, UK.
• Wong YT, Del-Rio-Martin J, Jaques B, Shaw JAM, Talbot D. Audit of diabetes in a renal transplant population. In: Transplantation Proceedings. 2005, Elsevier.
• Aldibbiat A, Scougall KT, Campbell SC, Macfarlane WM, Shaw JAM. Proinsulin overexpression as a tool for characterization of β-cell phenotype in transdifferentiation studies. Diabetes 2005, (under review).
• Ratanamart J, Huggins CG, Shaw JAM. Tetracycline-regulated human proinsulin secretion following plasmid-mediated gene transfer to muscle. In: British Society for Gene Therapy: 2nd Annual Meeting. 2005, Manchester, UK.
• Wilson MO, Scougall KT, Ratanamart J, McIntyre EA, Shaw JAM. Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle. Journal of Molecular Endocrinology 2005, 34(2), 391-403.
• Aldibbiat K, Scougall KT, Campbell SC, Macfarlane WM, Shaw J. Characterisation of pancreatic acinar cells for endocrine potential and determination of proinsulin processing and secretion following transfection with a human preproinsulin gene. In: Journal of Gene Medicine: 1st Annual Conference of the British Society for Gene Therapy. 2004, Oxford, UK: John Wiley & Sons, Inc.
• Ratanamart J, Scougall KT, Kirby JA, Shaw JAM. Establishment of an in vitro bioassay for immunogenicity of bacterial lipopolysaccharide and unmethylated CpG motifs in plasmid-derived gene therapy vectors. In: Journal of Gene Medicine: 1st Annual Conference of the British Society for Gene Therapy. 2004, Oxford, UK: John Wiley & Sons, Inc.
• Campbell RN, Shaw JAM, Macfarlane WM. Generation of glucose-responsive insulin expression constructs for use in a muscle-targeted gene therapy approach to the treatment of diabetes mellitus. In: Journal of Gene Medicine: 1st Annual Conference of the British Society for Gene Therapy. 2004, Oxford, UK: John Wiley & Sons, Inc.
• Wilson MO, Scougall KT, McIntyre E, Yeaman SJ, Walker M, Shaw JAM. Towards muscle-targeted gene therapy for diabetes: Tetracycline-repressible transcriptional regulation of (pro)insulin secretion in human muscle. In: 1st Annual Conference of the British Society for Gene Therapy. 2004, Keble College, Oxford: Journal of Gene Medicine: John Wiley & Sons Ltd.
• Wilson MO, McIntyre EA, Scougall KT, Shearing PA, Walker M, Yeaman SJ, Shaw JAM. Tetracycline-regulated (pro)insulin secretion and processing to mature insulin following plasmid-mediated transfection of human muscle. Diabetic Medicine 2003, 20(s2), 9.
• Scougall KT, Maltin CA, Shaw JAM. Tetracycline-regulated secretion of human insulin in a transfected non-endocrine cell line. Journal of Molecular Endocrinology 2003, 30(3), 331-346.
• Scougall KT, Shaw JAM. Tetracycline-regulated secretion of human insulin in transfected primary myoblasts. Biochemical and Biophysical Research Communications 2003, 304(1), 167-175.
• Shaw JAM, Pearson DWM, Krukowski ZH, Fisher PM, Bevan JS. Cushing's syndrome during pregnancy: Curative Adrenalectomy at 31 Weeks Gestation. European Journal of Obstetrics & Gynecology and Reproductive Biology 2002, 105(2), 189-191.
• Shaw JAM. Development of alternatives to insulin injection by genetic engineering. Diabetes Voice 2002, 47, 30-34.
• Shaw JAM, Docherty K. Genetic engineering in the treatment of diabetes. In: Wass, J.A.H., Shalet, S.M, ed. Oxford Textbook of Endocrinology and Diabetes. Oxford: Oxford University Press, 2002, pp.1866-1872.
• Unwin N, Shaw J, Zimmet P, Alberti KGMM. Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabetic Medicine 2002, 19(9), 708-723.
• Thomas RM, Korim MT, Kerrison M, Leech N, Shaw JAM. Retrospective audit of individuals with Type 1 diabetes mellitus with and without altered hypoglycaemia awareness / severe hypoglycaemia attending Newcastle Diabetes Centre. In: Endocrine Abstracts: 193rd Meeting of the Society for Endocrinology. 2002, London: BioScientifica Ltd.
• Shaw JAM, Delday MI, Hart AW, Docherty HM, Maltin CA, Docherty K. Secretion of bioactive human insulin following plasm id-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. European Journal of Endocrinology 2002, 172(3), 653-672.
• Zimmet P, Alberti KGMM, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414(6865), 782-787.
• Scougall KT, Shaw JAM. Tetracycline-regulated secretion of mature human insulin in transfected primary rat myoblasts. In: 37th Annual Meeting of the EASD. 2001, Glasgow, UK: Springer.
• Abraham P, Sati H, Kumar N, Shaw JAM, Middleton M, Culligan D, Watson H, Murray A, Bevan JS. Hyperprolactinaemia is uncommon in patients with Hodgkin’s and non-Hodgkin’s lymphoma. Journal of Endocrinology 2000, 164 Suppl, P35.
• Scougall KT, Maltin CA, Shaw JAM. Tetracycline-regulated secretion of human pro/insulin in transfected primary rat myoblasts. Diabetes Research and Clinical Practice 2000, 50((Suppl 1)), S180.
• Scougall KT, Shaw JAM. Tetracycline-responsive secretion of human proinsulin in transfected fibroblasts. Diabetic Medicine 2000, 17(3) Suppl 1, 4.
• Shaw JAM, Delday MI, Scougall KT, Hart A, Maltin CA, Docherty K. Constitutive secretion of human insulin in growing and mature rats following intramuscular injection of naked plasmid DNA. Journal of Endocrinology 1999, 163 Suppl, OC28.
• Shaw JAM and Docherty KD. Gene Therapy for NIDDM - will it have a role?. Towards Prediction and Prevention of NIDDM 1999.
• Shaw JAM, Docherty K. Gene therapy for type II diabetes: will it have a role?. In: Hitman, G.A, ed. Type II Diabetes: Prediction and Prevention. Oxford: Wiley-Blackwell, 1999, pp.367-381.
• Shaw JAM, Delday MI, Hart A, Docherty HM, Maltin CA, Docherty K. Towards off the shelf gene therapy for diabetes: insulin expression in rats following intramuscular DNA injection. Diabetic Medicine 1999, 16(5, s1), 28.