Staff Profile | Faculty of Medical Sciences

Professor Jeffrey Pearson

Professor of Molecular Physiology

Email: [email protected]
Telephone: +44 (0) 191 208 6996
Fax: +44 (0) 191 208 7424
Address: Institute for Cell and Molecular Biosciences
The Medical School
University of Newcastle upon Tyne
Framlington Place
Newcastle upon Tyne
NE2 4HH

Publications

Chater PI, Wilcox MD, Pearson JP. Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems. Advanced Drug Delivery Reviews 2018, 124, 184-192.
Bakshani CR, Morales-Garcia AL, Althaus M, Wilcox MD, Pearson JP, Bythell JC, Burgess G. Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection. npj Biofilms and Microbiomes 2018, 4(14), 1-12.
Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. American Journal of Respiratory and Critical Care Medicine 2018, 198(3), 340-349.
Yao A, Bates TJ, Pearson J, Robinson M, Ward C, Powell J. Laryngeal candidiasis: our experience from sixty biopsy specimens. Clinical Otolaryngology 2018, 43(2), 729-732.
Murphy DM, Ward C, Hunt EB, MacSharry J, Pearson JP. Response. Chest 2018, 153(4), 1077-1078.
Shellman Z, Aldhahrani A, Verdon B, Mather M, Paleri V, Wilson JA, Pearson J, Ward C, Powell J. Bile acids: a potential role in the pathogenesis of pharyngeal malignancy. Clinical Otolaryngology 2017, 42(5), 969-973.
Brownlee IA, Chater PI, Pearson JP, Wilcox MD. Dietary fibre and weight loss: Where are we now?. Food Hydrocolloids 2017, 68, 186-191.
Aldhahrani A, Verdon B, Ward C, Pearson J. Effects of Bile acids on Human Airway Epithelial Cells; implications for aerodigestive diseases. ERJ Open Research 2017, 3(1), 00107-2016.
Iglesias T, de Cerain AL, Irache JM, Martin-Arbella N, Wilcox M, Pearson J, Azqueta A. Evaluation of the cytotoxicity, genotoxicity and mucus permeation capacity of several surface modified poly(anhydride) nanoparticles designed for oral drug delivery. International Journal of Pharmaceutics 2017, 517(1-2), 67-79.
Al-momani H, Perry A, Jones R, Bourke S, Doe S, Perry J, Anderson A, Forrest T, Forrest I, Griffin M, Brodlie M, Pearson J, Ward C. Nontuberculous mycobacteria in gastrostomy fed patients with cystic fibrosis. Scientific Reports 2017, 7, 46546.
Brownlee IA, Gill S, Wilcox MW, Pearson JP, Chater PI. Starch digestion in the upper gastrointestinal tract of humans. Starch 2018, 70(9-10), 1700111.
Hunt EB, Ward C, Power S, Sullivan A, Pearson J, Lapthorne S, O'Byrne PM, Eustace J, Plant BJ, Maher MM, MacSharry J, Murphy DM. The potential role of aspiration in the asthmatic airway. Chest 2017, 151(6), 1272-1278.
Aldhahrani A, Powell J, Ladak S, Ali M, Ali S, Verdon B, Pearson J, Ward C. The Potential Role of Bile Acids in Acquired Laryngotracheal Stenosis. The Laryngoscope 2018, 128(9), 2029-2033.
Prufert F, Bonengel S, Kollner S, Griesser J, Wilcox MD, Chater PI, Pearson JP, Bernkop-Schnurch A. ζ potential changing nanoparticles as cystic fibrosis transmembrane conductance regulator gene delivery system: An in vitro evaluation. Nanomedicine 2017, 12(22), 2713-2724.
Jones R, Pearson J, Ward C. Functional Dyspepsia. New England Journal of Medicine 2016, 374, 895-896.
Chater PI, Wilcox M, Cherry P, Herford A, Mustar S, Wheater H, Brownlee I, Seal C, Pearson J. Inhibitory activity of extracts of Hebridean brown seaweeds on lipase activity. Journal of Applied Phycology 2016, 28(2), 1303-1313.
Zeybel GL, Pearson JP, Krishnan A, Bourke SJ, Doe S, Anderson A, Faruqi S, Morice AH, Jones R, McDonnell M, Zeybel M, Dettmar PW, Brodlie M, Ward C. Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation. Journal of Cystic Fibrosis 2016, 16(1), 124-131.
Al-Momani H, Perry A, Stewart CJ, Jones R, Krishnan A, Robertson AG, Bourke S, Doe S, Cummings SP, Anderson A, Forrest T, Griffin SM, Brodlie M, Pearson J, Ward C. Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients. Scientific Reports 2016, 6, 26985.
Hunt EB, Sullivan A, Ward C, Power S, Lapthorne S, Pearson J, Eustace J, Plant BJ, Maher MM, MacSharry J, Murphy DM. The Potential Role of Aspiration in the Asthmatic Airway Response. In: ITS Annual Scientific Meeting 2016. 2016, Dublin: Springer UK.
Pearson JP, Chater PI, Wilcox MD. The properties of the mucus barrier, a unique gel - how can nanoparticles cross it?. Therapeutic Delivery 2016, 7(4), 229-244.
Falconer J, Mahida R, Venkatesh D, Pearson J, Robinson JH. Unconventional T-cell recognition of an arthritogenic epitope of proteoglycan aggrecan released from degrading cartilage. Immunology 2016, 147(4), 389-398.
Powell J, Garnett J, Verdon B, Wilson J, Pearson J, Ward C. A Human in Vitro Model of the Subglottic Airway. Otolaryngology - Head and Neck Surgery 2015, 153(Suppl. 1), P83-P83.
Chater PI, Wilcox M, Brownlee I, Pearson JP. A synthetic model gut system to study macronutrient digestion in vitro. In: Proceedings of the Nutrition Society: Summer Meeting 2014. 2015, Cambridge University Press.
Chater PI, Wilcox MD, Brownlee IA, Pearson JP. Alginate as a protease inhibitor in vitro and in a model gut system; selective inhibition of pepsin but not trypsin. Carbohydrate Polymers 2015, 131, 142-151.
Houghton D, Chater P, Wilcox M, Brownlee I, Trenell MI, Seal C, Pearson J. Alginate enriched bread attenuates circulating lipids and non-alcoholic fatty liver disease. In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Azithromycin Attenuates Release Of Bile Acid-Mediated Neutrophilic And Remodeling Factors From Human Bronchial Epithelial Cells. In: American Thoracic Society International Conference. 2015, Denver, Colorado, USA: American Thoracic Society.
Brodlie M, Aseeri A, Lordan JL, Robertson AGN, McKean MC, Corris PA, Griffin SM, Manning NJ, Pearson JP, Ward C. Bile acid aspiration in people with cystic fibrosis before and after lung transplantation. European Respiratory Journal 2015, 46(6), 1820-1823.
McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Bile Acids Cause Direct Inflammation and Injury and Worsen Acid Induced Injury in the Pulmonary Epithelium. In: Irish Thoracic Society Annual Scientific Meeting 2015. 2015, Cork, Ireland: Springer.
McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Bile Acids Cause Direct Inflammation And Injury And Worsen Acid Induced Injury In The Pulmonary Epithelium. In: American Thoracic Society 2015 International Conference. 2015, Denver, Colorado, USA: American Thoracic Society.
Houghton D, Wilcox MD, Chater PI, Brownlee IA, Seal CJ, Pearson JP. Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity. Food Hydrocolloids 2015, 49, 18-24.
Griessinger J, Dunnhaupt S, Cattoz B, Griffiths P, Oh S, Gomez SBI, Wilcox M, Pearson J, Gumbleton M, Abdulkarim M, de Sousa IP, Bernkop-Schnurch A. Methods to determine the interactions of micro- and nanoparticles with mucus. European Journal of Pharmaceutics and Biopharmaceutics 2015, 96, 464-476.
de Sousa IP, Steiner C, Schmutzler M, Wilcox MD, Veldhuis GJ, Pearson JP, Huck CW, Salvenmoser W, Bernkop-Schnurch A. Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 2015, 97(Part A), 273-279.
Oh S, Wilcox M, Pearson JP, Borros S. Optimal design for studying mucoadhesive polymers interaction with gastric mucin using a quartz crystal microbalance with dissipation (QCM-D): Comparison of two different mucin origins. European Journal of Pharmaceutics and Biopharmaceutics 2015, 96, 477-483.
Wilcox MD, Van Rooij LK, Chater PI, de Sousa IP, Pearson JP. The effect of nanoparticle permeation on the bulk rheological properties of mucus from the small intestine. European Journal of Pharmaceutics and Biopharmaceutics 2015, 96, 484-487.
Chater PI, Wilcox MD, Pearson JP, Brownlee IA. The impact of dietary fibres on the physiological processes governing small intestinal digestive processes. Bioactive Carbohydrates and Dietary Fibre 2015, 6(2), 117-132.
Chater PI, Wilcox MD, Houghton D, Pearson JP. The role of seaweed bioactives in the control of digestion: implications for obesity treatments. Food & Function 2015, 6(11), 3420-3427.
Houghton D, Wilcox MD, Brownlee IA, Chater P, Seal CJ, Pearson JP. Method for quantifying alginate and determining release from a food vehicle in gastrointestinal digesta. Food Chemistry 2014, 151, 352-357.
Crossfield GL, Krishnan A, Bourke S, Anderson A, Gurney A, Dettmar PW, Brownlee I, Ward C, Pearson JP. Overweight and obesity challenges in the Cystic Fibrosis population - a need for revision in nutritional advice?. In: Nutrition Society Winter Meeting 2013, Diet, gut microbiology and human health. 2014, London, UK: Cambridge University Press.
Wilcox MD, Brownlee IA, Richardson J, Dettmar PW, Pearson JP. The modulation of pancreatic lipase activity by alginates. Food Chemistry 2014, 146, 479-484.
Houghton D, Wilcox M, Brownlee I, Seal C, Pearson J. Alginate enriched bread as an obesity treatment. In: 20th International Congress of Nutrition. 2013, Granada, Spain: S. Karger AG.
Parikh S, Brownlee IA, Robertson AG, Manning NT, Johnson GE, Brodlie M, Corris PA, Ward C, Pearson JP. Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?. Journal of Heart and Lung Transplantation 2013, 32(4), 418-423.
Griffin SM, Robertson AGN, Bredenoord AJ, Brownlee IA, Stovold R, Brodlie M, Forrest I, Dark JH, Pearson JP, Ward C. Aspiration and Allograft Injury Secondary to Gastroesophageal Reflux Occur in the Immediate Post-Lung Transplantation Period (Prospective Clinical Trial). Annals of Surgery 2013, 258(5), 705-712.
Ali MS, Parikh S, Chater P, Pearson JP. Bile acids in laryngopharyngeal refluxate: Will they enhance or attenuate the action of pepsin?. The Laryngoscope 2013, 123(2), 434-439.
Friedl H, Dünnhaupt S, Hintzen F, Waldner C, Parikh S, Pearson JP, Wilcox MD, Bernkop-Schnürch A. Development and Evaluation of a Novel Mucus Diffusion Test System Approved by Self-Nanoemulsifying Drug Delivery Systems. Journal of Pharmaceutical Sciences 2013, 102(12), 4406-4413.
Balasubramaniam V, Mustar S, Mustafa Khalid N, Abd Rashed A, Mohd Noh MF, Wilcox MD, Chater PI, Brownlee IA, Pearson JP. Inhibitory activities of three Malaysian edible seaweeds on lipase and α-amylase. Journal of Applied Phycology 2013, 25(5), 1405-1412.
Crossfield GL, Jackson W, Burke J, Woodcock AD, Strugala V, Ward C, Pearson JP, Dettmar PW, Morice AH. Pepsin detection despite the use of acid suppressant medication in patients with airway reflux related chronic cough. In: British Thoracic Society Winter Meeting 2013. 2013, London, UK: BMJ Publishing Group.
Robertson AGN, Krishnan A, Ward C, Pearson JP, Small T, Corris PA, Dark JH, Karat D, Shenfine J, Griffin SM. Anti-reflux surgery in lung transplant recipients: outcomes and effects on quality of life. European Respiratory Journal 2012, 39(3), 691-697.
Brownlee IA, Woodcock A, Zhang C, Li SQ, Pearson JP, Dettmar PW. Assessment of the potential of a novel detection method for measuring pepsin as a biomarker of reflux. In: Asian Pacific Digestive Week. 2012, Bangkok, Thailand: Wiley-Blackwell Publishing Asia.
Aseeri A, Brodlie M, Lordan J, Corris P, Pearson J, Ward C, Manning N. Bile Acids Are Present in the Lower Airways of People with Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2012, 185(4), 463-463.
Decalmer S, Stovold R, Houghton LA, Pearson J, Ward C, Kelsall A, Jones H, McGuinness K, Woodcock A, Smith JA. Chronic Cough: Relationship Between Microaspiration, Gastroesophageal Reflux, and Cough Frequency. Chest 2012, 142(4), 958-964.
Wilson CL, Hine DW, Pradipta A, Pearson JP, van Eden W, Robinson JH, Knight AM. Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4+T helper type 1 subset differentiation. Immunology 2012, 135(4), 344-354.
Kilarski LL, Pearson JP, Newsway V, Majounie E, Knipe MDW, Misbahuddin A, Chinnery PF, Burn DJ, Clarke CE, Marion MH, Lewthwaite AJ, Nicholl DJ, Wood NW, Morrison KE, Williams-Gray CH, Evans JR, Sawcer SJ, Barker RA, Wickremaratchi MM, Ben-Shlomo Y, Williams NM, Morris HR. Systematic Review and UK-Based Study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. Movement Disorders 2012, 27(12), 1522-1529.
Woodcock A, Li SQ, Zhang C, Pearson JP, Dettmar PW, Brownlee I. The effect of meal intake and physical activity on pepsin concentrations detected in the saliva of free-living, healthy individuals. In: Asian Pacific Digestive Week. 2012, Bangkok, Thailand: Wiley-Blackwell Publishing Asia.
Pearson JP, Parikh S. Review article: reflux and its consequences - the laryngeal, pulmonary and oesophageal manifestations. In: Alimentary Pharmacology and Therapeutics: 9th International Symposium on Human Pepsin (ISHP). 2011, Kingston upon Hull, UK: Wiley-Blackwell Publishing Ltd.
Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Measuring mucus thickness in reef corals using a technique devised for vertebrate applications. Marine Biology 2010, 157(2), 261-267.
Jatkar AA, Brown BE, Bythell JC, Guppy R, Morris NJ, Pearson JP. Coral Mucus: The Properties of Its Constituent Mucins. Biomacromolecules 2010, 11(4), 883-888.
Bulmer DM, Ali MS, Brownlee IA, Dettmar PW, Pearson JP. Laryngeal Mucosa: Its Susceptibility to Damage by Acid and Pepsin. Laryngoscope 2010, 120(4), 777-782.
Robertson AGN, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM. Lung Transplantation, Gastroesophageal Reflux, and Fundoplication. Annals of Thoracic Surgery 2010, 89(2), 653-660.
Brodlie M, McKean MC, Johnson GE, Perry JD, Nicholson A, Verdon B, Gray MA, Dark JH, Pearson JP, Fisher AJ, Corris PA, Lordan J, Ward C. Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs. Experimental Lung Research 2010, 36(2), 101-110.
Pearson JP, Brownlee IA. The Interaction of Large Bowel Microflora with the Colonic Mucus Barrier. International Journal of Inflammation 2010, Article ID 321426.
Robertson AGN, Shenfine J, Ward C, Pearson JP, Dark JH, Corris PA, Griffin SM. A Call for Standardization of Antireflux Surgery in the Lung Transplantation Population. Transplantation 2009, 87(8), 1112-1114.
Brownlee IA, Seal CJ, Wilcox M, Dettmar PW, Pearson JP. Applications of Alginates in Food. In: Rehm, BHA, ed. Alginates: Biology and applications. Berlin, Germany: Springer, 2009, pp.211-228.
Robertson AGN, Griffin SM, Ward C, Pearson JP, Bredenoord AJ, Dark JH, Fisher AJ, Lodean J, Corris PA. Aspiration in the Immediate Post Lung Transplantation Period. In: Journal of Heart and Lung Transplantation:29th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation. 2009, Paris, France: Elsevier Inc.
Robertson AGN, Ward C, Pearson JP, Bredenoord AJ, Fisher AJ, Lordan J, Corris PA, Dark JH, Griffin SM. Aspiration Secondary to Gastro-Oesophageal Reflux but not Duodenal Reflux Occurs in the Immediate Post Lung Transplantation Period. In: Transplant International: 14th Congress of the European Society for Organ Transplantation. 2009, Paris, France: Wiley-Blackwell Publishing Ltd.
Robertson AGN, Ward C, Pearson JP, Small T, Lordan J, Fisher AJ, Bredenoord AJ, Dark J, Griffin SM, Corris PA. Longitudinal changes in gastro-oesophageal reflux from 3 months to 6 months after lung transplantation. Thorax 2009, 64(11), 1005-1007.
Robertson AGN, Griffin SM, Murphy DM, Pearson JP, Forrest IA, Dark JH, Corris PA, Ward C. Targeting Allograft Injury and Inflammation in the Management of Post-Lung Transplant Bronchiolitis Obliterans Syndrome. American Journal of Transplantation 2009, 9(6), 1272-1278.
Stovold R, Forrest I, Murphy D, Johnston G, Lordan J, Fisher A, Dark J, Corris P, Pearson J, Ward C. Temporal Patterns of Lung Pepsin Levels in Allografts Suggest Aspiration Is an Ongoing Injury, Which Can Occur Early Following Lung Transplantation. In: Journal of Heart and Lung Transplantation: 29th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation. 2009, Paris, France: Elsevier Inc.
Brownlee IA, Atherton MR, Havler ME, Dettmar PW, Allen A, Pearson JP. The effect of dietary fibre intake on mucus secretion in the rat colon. In: Williams, P.A., Phillips, G.O, ed. Gums and stabilizers for the food industry. London, UK: Royal Society of Chemistry, 2009, pp.526-534.
Stovold R, Corris PA, Fisher AJ, Lordan JL, Pearson JP, Ward C. Does pepsin in gastric juice aspirated into the lung allograft stimulate mucus hypersecretion?. In: 28th Annual Meeting of the International Society for Heart and Lung Transplantation. 2008, Boston, MA: Journal of Heart and Lung Transplantation: Elsevier.
Stovold R, Forrest IA, Murphy DM, Johnson GE, Lordan J, Fisher AJ, Corris PA, Pearson JP, Ward C. Longitudinal assessment of pepsin levels in lung allografts suggests aspiration is an ongoing injury, which can occur early following lung transplantation. In: Thorax: Winter Meeting of the British Thoracic Society. 2008, London, UK: BMJ Publishing Group.
Robertson AGN, Griffin SM, Ward C, Pearson JP, Bredenoord AJ, Dark JH, Fisher AJ, Lordan J, Corris PA. Qualitative and quantitative assessments of aspiration in the immediate post-lung transplantation period. In: Thorax: Winter Meeting of the British Thoracic Society. 2008, London, UK: BMJ Publishing Group.
Decalmer S, Stovold R, Jones H, Pearson J, Ward C, Houghton LA, Kelsall A, McGuinness K, Woodcock AA, Smith JA. Relationships between micro-aspiration, gastro-oesophageal reflux and cough in chronic cough subjects. In: British Thoracic Society Winter Meeting. 2008, London: Thorax: BMJ Publishing Group.
Brodlie M, McKean MC, Perry J, Nicholson A, Johnson GE, Pearson JP, Fisher A, Corris PA, Lordan JL, Ward C. The culture of primary bronchial epithelial cells from the lungs of people with cystic fibrosis removed at the time of transplantation: a model to study cystic fibrosis lung disease. In: British Thoracic Society Winter Meeting 2008. 2008, London: Thorax: BMJ Publishing Group.
Strugala V, Dettmar PW, Pearson JP. Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn's disease. International Journal of Clinical Practice 2008, 62(5), 762-769.
Brownlee IA, Knight J, Dettmar PW, Pearson JP. Action of reactive oxygen species on colonic mucus secretions. Free Radical Biology and Medicine 2007, 43(5), 800-808.
Ali MS, Wilson JA, Bennett MK, Pearson JP. Mucin gene expression in hypertrophic adenoids. Acta Oto-Laryngologica 2007, 127(10), 1080-1085.
Stovold R, Forrest IA, Corris PA, Murphy DM, Smith JA, Decalmer S, Johnson GE, Dark JH, Pearson JP, Ward C. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection. American Journal of Respiratory and Critical Care Medicine 2007, 175(12), 1298-303.
Stovold R, Forrest IA, Corris PA, Murphy DM, Smith JA, Decalmer S, Johnson GE, Dark JH, Pearson JP, Ward C. Pepsin, a biomarker of gastric aspiration in lung allografts: A putative association with rejection. American Journal of Respiratory and Critical Care Medicine 2007, 175(12), 1298-1303.
Ali MS, Pearson JP. Upper airway mucin gene expression: A review. Laryngoscope 2007, 117(5), 932-938.
Viswanathan H, Brownlee IA, Pearson JP, Carrie S. MUC5B secretion is up-regulated in sinusitis compared with controls. American Journal of Rhinology 2006, 20(5), 554-557.
Brownlee IA, Dettmar PW, Strugala V, Pearson JP. The interaction of dietary fibres with the colon. Current Nutrition and Food Science 2006, 2(3), 243-264.
Brownlee IA, Allen A, Pearson JP, Dettmar PW, Havler ME, Atherton MR, Onsoyen E. Alginate as a source of dietary fiber. Critical Reviews in Food Science and Nutrition 2005, 45(6), 497-510.
Smirnova MG, Birchall JP, Pearson JP. Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion. Acta Oto-Laryngologica 2005, 125(10), 1043-1050.
Gill GA, Johnston N, Buda A, Pignatelli M, Pearson J, Dettmar PW, Koufman J. Laryngeal epithelial defenses against laryngopharyngeal reflux: Investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin. Annals of Otology, Rhinology and Laryngology 2005, 114(12), 913-921.
Ali MS, Hutton DA, Wilson JA, Pearson JP. Major secretory mucin expression in chronic sinusitis. Otolaryngology - Head and Neck Surgery 2005, 133(3), 423-428.
Ali MS, Wilson JA, Bennett M, Pearson JP. Mucin gene expression in nasal polyps. Acta Oto-Laryngologica 2005, 125(6), 618-624.
Ward C, Forrest IA, Brownlee IA, Johnson GE, Murphy DM, Pearson JP, Dark JH, Corris PA. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005, 60(10), 872-874.
Taylor C, Pearson JP, Draget KI, Dettmar PW, Smidsrod O. Rheological characterisation of mixed gels of mucin and alginate. Carbohydrate Polymers 2005, 59(2), 189-195.
Pearson JP, Brownlee IA. Structure and function of mucosal surfaces. In: Nataro, J.P., et al, ed. Colonization of Mucosal surfaces. Washington, DC: ASM Press, 2005, pp.3-16.
N'Dow, J., Jordan, N., Robson, C. N., Neal, D. E., Pearson, J. P. The bladder does not appear to have a dynamic secreted continuous mucous gel layer. Journal of Urology 2005, 173(6), 2025-2031.
Ward C, Headland L, Vest S, Brownlee IA, Forrest IA, Ward TA, Pritchard G, Murphy DM, Pearson JP, Dark J, Corris P. Clinically silent gastric aspiration is common in lung allografts. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA. Expression of much gene products in laryngeal squamous cancer. Otolaryngology - Head and Neck Surgery 2004, 131(1), 84-88.
Fergie N, Bayston R, Pearson JP, Birchall JP. Is otitis media with effusion the result of a biofilm infection?. Clinical Otolaryngology 2004, 29(1), 38-46.
Pearson JP, Brownlee IA, Taylor C. Mucin genes in the GI tract. In: Williams, P.A., Phillips, G.O, ed. Gums and Stabilisers for the Food Industry. Cambridge: Royal Society of Chemistry, 2004, pp.517-525.
N'Dow J, Pearson J, Neal D. Mucus production after transposition of intestinal segments into the urinary tract. World Journal of Urology 2004, 22(3), 178-185.
Brownlee IA, Hart JL, Dore MPE, Fenton DI, Dettmar PW, Pearson JP. Pancreatic proteases retain activity through stomach-like conditions, and increase oesophageal damage by pepsin. In: 105th Annual Meeting of the American Gastroenterological Association. 2004, New Orleans, LA, USA: W.B. Saunders Co.
Brownlee IA, Ward C, Forrest I, Pritchard G, Murphy D, Dark J, Corris PA, Pearson JP. Pepsin detection in the lungs of transplant patients: Evidence of gastric refluxate. In: 105th Annual Meeting of the American Gastroenterological Association. 2004, New Orleans, LA, USA: W.B. Saunders Co.
Smirnova MG, Birchall JP, Pearson JP. The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediators of Inflammation 2004, 13(2), 75-88.
Bulmer D, Ross PE, Axford SE, Johnston N, Gill GA, Pearson JP, Dettmar PW, Panetti M, Pignatelli M, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease: Further studies. Annals of Otology, Rhinology and Laryngology 2003, 112(6), 481-491.
Keegan SJ, Graham C, Neal DE, Blum-Oehler G, N'Dow J, Pearson JP, Gally DL. Characterization of Escherichia coli strains causing urinary tract infections in patients with transposed intestinal segments. Journal of Urology 2003, 169(6), 2382-2387.
Brownlee IA, Havler ME, Dettmor PW, Allen A, Pearson JP. Colonic microflora metabolites alter the protective capacity of the colonic mucus layer in vivo. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2003, Birmingham, UK: BMJ Group.
Strugala V, Allen A, Dettmar PW, Pearson JP. Colonic mucin: Methods of measuring mucus thickness. Proceedings of the Nutrition Society 2003, 62(1), 237-243.
Brownlee IA, Atherton MR, Havler ME, Dettmar PW, Onsoyen E, Allen A, Pearson JP. Colonic mucus barrier dynamics and mucosal haemaglobin content are modulated by dietary fibre. In: 104th Annual Meeting of the American Gastroenterological Association. 2003, Orlando, Florida, USA: W.B. Saunders Co.
Brownlee IA, Havler ME, Dettmar PW, Allen A, Pearson JP. Colonic mucus: Secretion and turnover in relation to dietary fibre intake. Proceedings of the Nutrition Society 2003, 62(1), 245-249.
Brownlee IA, Atherton MA, Havler ME, Dettmar PW, Allen A, Pearson JP. Dietary fibre modulates the protective potential of the colonic mucus barrier and mucosal health. In: Gut: Annual Meeting of the British Society of Gastroenterology. 2003, Birmingham, UK: BMJ Group.
Capper R, Guo L, Pearson JP, Birchall JP. Effect of nitric oxide donation on mucin production in vitro. Clinical Otolaryngology and Allied Sciences 2003, 28(1), 51-54.
Smirnova MG, Guo L, Birchall JP, Pearson JP. LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. Cellular Immunology 2003, 221(1), 42-49.
Taylor C, Allen A, Dettmar PW, Pearson JP. The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations. Biomacromolecules 2003, 4(4), 922-927.
Keegan SJ, Hormaeche CE, Pearson JP, Gally DL. Characterisation and adherence mechanisms of Escherichia colistrains causing infections in patients with a reconstructed bladder. Advances in Experimental Medicine and Biology 2002, 485, 263-271.
Smirnova MG, Birchall JP, Pearson JP. In vitro study of IL-8 and goblet cells: Possible role of IL-8 in the aetiology of otitis media with effusion. Acta Oto-Laryngologica 2002, 122(2), 146-152.
Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Is gastric reflux a cause of otitis media with effusion in children?. In: Laryngoscope: 105th Annual Meeting of the Triological Society. 2002, Boca Raton, Florida, USA: John Wiley & Sons, Inc.
Ali MS, Wilson JA, Pearson JP. Mixed nasal mucus as a model for sinus mucin gene expression studies. Laryngoscope 2002, 112(2), 326-331.
Tasker A, Dettmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children. Lancet 2002, 359(9305), 493.
Smirnova MG, Birchall JP, Pearson JP. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. European Cytokine Network 2002, 13(2), 161-172.
Smirnova MG, Kiselev SL, Gnuchev NV, Birchall JP, Pearson JP. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. European Cytokine Network 2002, 13(2), 161-172.
Panetti M, Pearson JP, Dettmar PW, Koufman JA. Active pepsin in airway secretions: Possible evidence for new supraesophageal pH criteria. In: 102nd Annual Meeting of the American Gastroenterological Association. 2001, Atlanta, Georgia, USA: W.B. Saunders Co.
Axford SE, Sharp N, Ross PE, Pearson JP, Dettmar PW, Panetti M, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease. Annals of Otology, Rhinology and Laryngology 2001, 110(12), 1099-1108.
Axford SE, Sharp N, Ross PE, Pearson JP, Dettmar PW, Panetti M, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease: Preliminary studies. Annals of Otology Rhinology and Laryngology 2001, 110(12), 1099-1108.
Dixon J, Strugala V, Griffin SM, Welfare MR, Dettmar PW, Allen A, Pearson JP. Esophageal mucin: An adherent mucus gel barrier is absent in the normal esophagus but present in columnar-lined Barrett's esophagus. American Journal of Gastroenterology 2001, 96(9), 2575-2583.
Hanson JM, Broweil DA, Cunliffe WJ, Varma J, Allen A, Hemming D, Shenton BK, Young JR, Higgs MJ, Brotherick I, Pearson JP. MUC1 expression in primary breast cancer: The effect of tamoxifen treatment. Breast Cancer Research and Treatment 2001, 67(3), 215-222.
Tasker A, Murphy F, Singh AE, Dettmar PW, Birchall JP, Pearson JP. MUC5B is the viscous component of middle ear effusions. In: 4th Extraordinary International Symposium on Recent Advances in Otitis Media. 2001, Sendai, Japan: Medimond SRL.
N'Dow J, Pearson JP, Bennett MK, Neal DE, Robs CN. Mucin gene expression in human urothelium. Journal of Otolaryngology 2001, 166, 219-220.
Pearson JP, Roberts NB. Mucosal protective effects of ecabet sodium: pepsin inhibition and interaction with mucus. Clinical Science 2001, 100(4), 411-417.
Tasker A, Dettmar PW, Birchall JP, Pearson JP. Pepsin in the middle ear - A reflux too far?. In: 4th Extraordinary International Symposium on Recent Advances in Otitis Media. 2001, Sendai, Japan: Medimond SRL.
N'Dow, J., Robson, C. N., Matthews, J. N. S., Neal, D. E., Pearson, J. P. Reducing mucus production after urinary reconstruction: A prospective randomized trial. Journal of Urology 2001, 165(5), 1433-1440.
Taylor C, Allen A, Dettmar PW, Pearson JP. Rheological studies of breakdown and reformation of gastric mucus gel demonstrates its unique flow properties which are essential to the maintenance of an intact protective barrier. In: British Society of Gastroenterology Annual Meeting. 2001, Glasgow, UK: BMJ Group.
Strugala V, Hainsworth PJ, Bennett MK, Hudson M, Dettmar PW, Allen A, Pearson JP. Thickness and continuity of the human colonic mucus layer is decreased in active UC but remains normal in quiescent UC. In: British Society of Gastroenterology Annual Meeting. 2001, Glasgow, UK: BMJ Group.
Smirnova MG, Kiselev SL, Birchall JP, Pearson JP. Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6. European Cytokine Network 2001, 12(1), 119-125.
Sunderland AM, Dettmar PW, Pearson JP. Alginates inhibit pepsin activity in vitro; A justification for their use in gastro-oesophageal reflux disease (gord). Gastroenterology 2000, 118(4), A21-A21.
Keegan SJ, Hormaeche CE, Pearson JP, Gally DL. Characterisation and adherence mechanisms of Escherichia coli strains causing infections in patients with a reconstructed bladder. Advances in Experimental Medicine and Biology 2000, 485(III), 263-271.
Strugala V, Allen A, Havler ME, Dettmar PW, Pearson JP. Deprivation of non-starch polysaccharides in the rat diet causes mucosal damage. In: Digestive Disease Week and the 101st Annual Meeting of the American Gastroenterological Association. 2000, San Diego, USA: American Gastroenterology Association.
Peizhong L, Whatmough K, Birchall JP, Wilson JA, Pearson JP. Does the bacterial DNA found in middle ear effusions come from viable bacteria?. Clinical Otolaryngology and Allied Sciences 2000, 25(6), 570-576.
Taylor C, Allen A, Dettmar PW, Pearson JP. Evidence for two discrete mucus secretions in the normal stomach. In: GASTROENTEROLOGY. 2000.
N'Dow, J., Pearson, J. P., Bennett, M. K., Neal, D. E., Robson, C. N. Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract. Journal of Urology 2000, 164(4), 1398-1404.
Strugala V, Pearson JP, Dettmar PW, Havler ME, Allen A. Mucosal bleeding in the rat colon occurs when non-starch polysaccharide is absent from the diet. In: GUT. 2000.
Severn TL, Hutton DA, Birchall JP, Pearson JP. Preliminary studies on mucin gene expression by human middle ear mucosa. Edited by Bara, J.; Christen, Y.; Droy-Lefaix, M.T. in Digestive mucus from research to clinical implications published by Irvin editions 119-123 2000.
Hutton DA, Allen A, Pearson JP. Proteinase Activity. In: Corfield, A.P, ed. Glycoprotein Methods and Protocols: The Mucins. Humana Press Inc, 2000, pp.393-401.
Knight J, Pearson JP, Droy-Lefaix MT, Allen A. Quenching of free radicals by mucus secretions. In: Bara, J; Christen, Y; Droy-Lefaix, MT, ed. Digestive mucus, from research to clinical implications. Irvin editions, 2000, pp.65-67.
Pearson JP, Allen A, Hutton DA. Rheology of Mucin. In: Corfield, A.P, ed. Glycoprotein Methods and Protocols: The Mucins. Humana Press Inc, 2000, pp.99-109.
Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: A review. Clinical Otolaryngology and Allied Sciences 2000, 25(3), 181-194.
Allen A, Pearson JP. The Gastrointestinal adherent mucous gel barrier. Methods in Molecular Biology 2000, 125(II), 57-64.
Fergie N, Guo L, Pearson JP, Birchall JP. The influence of prednisolone on the secretion of MUC5AC from TH29-MTX cell culture. Clinical Otolaryngology and Allied Sciences 2000, 25(6), 570-576.
Smirnova MG, Birchall JP, Pearson JP. TNF-alpha in the regulation of MUC5AC secretion: Some aspects of cytokine-induced mucin hypersecretion on the in vitro model. Cytokine 2000, 12(11), 1732-1736.
Strugala V, Dettmar PW, Pearson JP, Allen A. Two forms of the colonic mucus barrier. Edited by Bara, J; Christen, Y; Droy-Lefaiz, M.T. in Digestive mucus from research to clinical implications published by Irvin editions 143-147 2000.
Dixon J, Pearson JP, Griffin M, Welfare M, Dettmar PW, Allen A. A mucus gel barrier is present in Barrett's oesophagus but is not present in normal oesophagus. Gut 1999, 44(supplement 1), A109-A109.
Knight J, Droy-Lefaix MT, Allen A, Pearson JP. Extensive quenching of free radicals by mucus secretions. In: Gastroenterology. 1999, W.B. Saunders Co.
Strugala V, Dettmar PW, Pearson JP, Allen A. Is the colonic mucus barrier multilayered?. In: Gastroenterology. 1999, W.B. Saunders Co.
Birchall JP, Hutton DA, Guo L, Pearson JP. MUC 5B is the major mucin in middle ear mucosal glands. In: 7th International Symposium on Recent Advances in Otitis Media. 1999, Fort Lauderdale, Florida, USA.
Ali MS, Hutton DA, Pearson JP, Wilson JA. Mucin expression by the sinus mucosa in chronic sinusitis patients. In: 10th British Academic Conference in Otolaryngology. 1999, Cambridge, UK.
Dixon J, Pearson JP, Griffin MS, Welfare M, Dettmar PW, Allen A. Mucus gel barrier absent in normal oesophagus but present in Barrett's oesophagus. In: Gastroenterology. 1999, W.B. Saunders Co.
Pearson J, Murchison D. Relationship between reflectance and volatile-matter yield at the Maudlin (H) horizon of the offshore Northumberland and Durham coalfields. Fuel 1999, 78(12), 1417-1423.
Pearson JP, Rankin BJ, Hutton DA, Birchall JP, Wilson J. Selective upregulation of MUC 5B expression in otitis media with effusion (OME). In: 7th International Symposium on Recent Advances in Otitis Media. 1999, Fort Lauderdale, Florida, USA.
Strugala V, Dettmar PW, Havler ME, Pearson JP, Allen A. The effect of non-starch polysaccarides on the colonic mucus layer. In: Gut. 1999, BMJ Group.
Hutton D.A., Fogg F.J.J., Kubba H., Birchall J.P. and Pearson J.P. Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: evidence for the expression of different mucin gene products. Glycoconjugate Journal 1998, 15, 283-291.
N'Dow J, Pearson JP, Bennett M, Robson CN, Neal DE. Mucin gene expression in ileal segments transposed to the urinary tract. In: XIIth Congress of the European Association of Urology. 1998, Paris: Karger.
N'Dow JM, Pearson JP, Bennett M, Neal DE, Robson CN. Mucin gene expression in normal bladder and expression of MUC2 in TCC of the bladder. British Journal of Urology 1998, 81(4), 24-.
N'Dow JM, Pearson JP, Neal DE, Robson CN. Does normal urine contain mucin?. British Journal of Urology 1997, 80(1), 161-162.
N'Dow, J., Pearson, J. P., Sunderland, A. M., Neal, D. E., Robson, C. N. The protective layer of the bladder: Is it mucin?. British Journal of Urology 1997, 80(Supplement 2), 7.
Carrie S, Hutton DA, Birchall JP, Green GGR, Pearson JP. Otitis Media with Effusion: Components Which Contribute to the Viscous Properties. Acta Oto-Laryngologica 1992, 112(3), 504-511.