Staff Profile

Roles and Responsibilities

Academic lead for preclinical imaging; CT/in vivo imaging system (IVIS)/MR  https://www.ncl.ac.uk/pivi/

Qualifications

1994-1997 – BSc Physiology and Biochemistry, University of Southampton
December 2000 - PhD awarded, University of Southampton

Previous Positions

1/10/05-31/08/06 School of Medicine Career Track Award, University of Southampton
02/04/03-30/08/05 Post doctoral scientist Wellcome Trust, University of Southampton
01/07/00- 31/03/03 Post doctoral scientist MRC, University of Southampton

Memberships

British Association for the Study of Liver disease (BASL), Basic Science committee member.

European Association for the Study of Liver disease (EASL).

Honours and Awards

Dame Sheila Sherlock Young Investigator Award 2006.

Newton Prize - Egypt country prize 2020 - with Prof Helen Reeves and Dr Marco Zaki

Research Interests

Current research projects include investigating the discrete biological functions of the c-Rel subnit of NF-kB subunits in heart and skin physiology and disease. Other work involves understanding how NF-kappaB and serotonin signaling regulates liver inflammation, fibrosis and regeneration. 

Postgraduate Supervision

currently supervise two postgraduate students

Funding

May 2010. Medical Research Council New Investigator Research Grant (NIRG). RelA Serine 536 Phosphorylation as a Selective Therapeutic Target in Fibrotic Disease. 

Awarded May 2008: Wellcome Trust, the role of hepatic myofibroblasts in hepatic injury and regeneration. PI Matthew Wright, co-applicants Derek Mann, Fiona Oakley and Alastair Burt.

Awarded March 2008: MRC Mres/PhD Studentship - NF-Kappaβ Signalling is a Critical Regulator of Skin Ageing – Do Manipulating Specific Components of NF-kappaβ Signalling Rejuvenate Skin? Fiona Oakley, Derek Mann, Nick Reynolds, Mark Birch-Machin.

Awarded November 2007, MRC research grant: A functional dissection of the serotonin system in liver disease. 2 years. PI Derek Mann, co-applicants Fiona Oakley and Matthew Wright.

Gerald kerkut charitable Trust funded PhD studentship. The role of nfkb1 in cardiovascular physiology. Co-applicants Prof. Derek Mann (Newcastle, ICM) and Dr Paul Townsend (University of Southampton)

Undergraduate Teaching

Supervise undergraduate lab projects

Postgraduate Teaching

Supervising three PhD students

Supervising two masters students

• Gawish R, Maier B, Obermayer G, Watzenboeck ML, Gorki A-D, Quattrone F, Farhat A, Lakovits K, Hladik A, Korosec A, Alimohammadi A, Mesteri I, Oberndorfer F, Oakley F, Brain J, Boon L, Lang I, Binder CJ, Knapp S. A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4. eLife 2022, 11, e78291.
• Madgwick S, Luli S, Sellier H, Butterworth JA, Leslie J, Moore AJ, Corbin EK, Yemm AI, Chiremba RT, Tiniakos D, Oakley F, Perkins ND, Hunter JE. Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential. Biochemical Journal 2022, 479(19), 2115-2130.
• Leslie J, Hunter JE, Collins A, Rushton A, Russell LG, Ramon-Gil E, Laszczewska M, McCain M, Zaki MYW, Knox A, Seow Y, Sabater L, Geh D, Perkins ND, Reeves HL, Tiniakos D, Mann DA, Oakley F. c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis. Hepatology 2023, 78(4), 1050-1063.
• Oakley F. Interrogating mechanisms of liver fibrosis with omics. Nature Reviews Gastroenterology and Hepatology 2022, 19, 89–90.
• Hall Z, Oakley F, Vacca M, Griffin JL. Reply. Hepatology 2022, 75(5), 1347-1348.
• Wijayasiri P, Astbury S, Kaye P, Oakley F, Alexander GJ, Kendall TJ, Aravinthan AD. Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression. Cells 2022, 11(14), 2221.
• Bilkei-Gorzo O, Heunis T, Marin-Rubio JL, Cianfanelli FR, Raymond BBA, Inns J, Fabrikova D, Peltier J, Oakley F, Schmid R, Hartlova A, Trost M. The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection. EMBO Journal 2022, 41(23), e108970.
• Gee L, Oakley F. 5-HT_2B Receptors in Liver. In: Receptors. Humana Press Inc, 2021, pp.247-264.
• Garcia-Macia M, Santos-Ledo A, Leslie J, Paish HL, Collins AL, Scott RS, Watson A, Burgoyne RA, White S, French J, Hammond J, Borthwick LA, Mann J, Bolanos JP, Korolchuk VI, Oakley F, Mann DA. A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis. Hepatology 2021, 74(6), 3441-3459.
• Barcena-Varela M, Paish H, Alvarez L, Uriarte I, Latasa MU, Santamaria E, Recalde M, Garate M, Claveria A, Colyn L, Arechederra M, Iraburu MJ, Milkiewicz M, Milkiewicz P, Sangro B, Robinson SM, French J, Pardo-Saganta A, Oyarzabal J, Prosper F, Rombouts K, Oakley F, Mann J, Berasain C, Avila MA, Fernandez-Barrena MG. Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: Dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis. Gut 2021, 70(2), 388-400.
• Zaki MYW, Mahdi AK, Patman GL, Whitehead A, Mauricio JP, McCain MV, Televantou D, Abou-Beih S, Ramon-Gil E, Watson R, Cox C, Leslie J, Wilson C, Govaere O, Lunec J, Mann DA, Nakjang S, Oakley F, Shukla R, Anstee QM, Tiniakos D, Reeves HL. Key features of the environment promoting liver cancer in the absence of cirrhosis. Scientific Reports 2021, 11(1), 16727.
• Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pelligrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, VidalPuig A, Oakley F, Vacca M, Griffin JL. Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma . Hepatology 2021, 73(3), 1028-1044.
• Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Grazia Vizioli M, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, Von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. The EMBO Journal 2021, 40(9), e106048.
• Leslie J, Robinson SM, Oakley F, Luli S. Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging. Scientific Reports 2021, 11, 1415.
• Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohooly-Y M, Acharjee A, Linden D, Bidualt G, Petsalaki E, Griffin Jl, Oakley F, Allison ME, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Molecular Metabolism 2021, 48, 101210.
• Esparza-Baquer A, Labiano I, Sharif O, Agirre-Lizaso A, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Jimenez-Agüero R, Riaño I, Landa A, La Casta A, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ. TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. Gut 2021, 70(7), 1345-1361.
• Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature Cancer 2020, 1, 976-989.
• Fielder E, Tweedy C, Wilson C, Oakley F, LeBeau FEN, Passos JF, Mann DA, von Zglinicki T, Jurk D. Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice. Aging Cell 2020, 19(10), e13188.
• Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Bone Morphogenic Protein 8B Promotes the Progression of Non-Alcoholic Steatohepatitis. Nature Metabolism 2020, 2, 514-531.
• Worrell J, Leslie J, Smith GR, Zaki M, Paish H, Knox A, James ML, Cartwright TN, OReily S, Kania G, Distler O, Distler J, Herrick A, Jeziorska M, Borthwick LA, Fisher AJ, Mann J, Mann DA, Oakley F. cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis. Rheumatology 2020, 59(12), 3939-3951.
• Leslie J, Garcia Macia M, Luli S, Worrell JC, Reilly W, Paish HL, Knox A, Barksby BS, Gee LM, Zaki MYW, Collins A, Burgoyne RA, Cameron R, Bragg C, Xu X, Chung GW, Brown CDA, Blanchard AD, Nanthakumar CB, Karsdal M, Robinson SM, Manas DM, Sen G, French J, White SA, Murphy S, Trost M, Zakrzewski JL, Klein U, Schwabe RF, Mederacke I, Nixon C, Bird T, Teuwen LA, Schoonjans L, Carmeliet P, Mann J, Fisher AJ, Sheerin NS, Borthwick LA, Mann DA, Oakley F. c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis. Nature Metabolism 2020, 2, 1350-1367.
• Leslie J, Millar BJM, del Carpio Pons A, Burgoyne RA, Frost JD, Barksby BS, Luli S, Scott J, Simpson JA, Gauldie J, Murray LA, Finch DK, Carruthers AM, Ferguson J, Sleeman MA, Rider D, Howarth R, Fox C, Oakley F, Fisher AJ, Mann DA, Borthwick LA. FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis. JCI Insight 2020, 5(4), e125937.
• Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, De Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, Van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JHW, Kania G, Frank-Bertoncelj M, Distler O. Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis. Journal of Clinical Investigation 2020, 130(9), 4888-4905.
• Cairns JT, Habgood A, Edwards-Pritchard RC, Joseph C, John AE, Wilkinson C, Stewart ID, Leslie J, Blaxall BC, Susztak K, Alberti S, Nordheim A, Oakley F, Jenkins G, Tatler AL. Loss of ELK1 has differential effects on age-dependent organ fibrosis. The International Journal of Biochemistry & Cell Biology 2020, 120, 105668.
• Leitch AC, Abdelghany TM, Charlton A, Grigalyte J, Oakley F, Borthwick LA, Reed L, Knox A, Reilly WJ, Agius L, Blain PG, Wright MC. Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse. Ecotoxicology and Environmental Safety 2020, 202, 110902.
• Sabater L, Locatelli L, Oakley F, Hardy T, French J, Robinson SM, Sen G, Mann DA, Mann J. RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat. Scientific Reports 2020, 10(1), 21708.
• Paish H, Reed L, Brown H, Bryan M, Govaere O, Leslie J, Barksby B, GarciaMacia M, Watson A, Xu X, Zaki M, Greaves L, Whitehall J, French J, White S, Manas D, Robinson S, Spoletini G, Griffiths C, Mann DA, Borthwick LA, Drinnan M, Mann J, Oakley F. A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices. Hepatology 2019, 70(4), 1377-1391.
• De Chiara F, Thomsen KL, Habtesion A, Jones H, Davies N, Gracia-Sancho J, Manicardi N, Hall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, Mookerjee RP, Mann J, Jalan R. Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease. Hepatology 2019, (ePub ahead of Print).
• Sirbu D, Luli S, Leslie J, Oakley F, Benniston AC. Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice using a Highly Bright Near-Infrared BODIPY Dye. ChemMedChem 2019, 14(10), 995-999.
• Oakley F, Gee LM, Sheerin NS, Borthwick LA. Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy. Current Opinion in Pharmacology 2019, 49, 95-101.
• Perugorria MJ, Esparza-Baquer A, Oakley F, Labiano I, Korosec A, Jais A, Mann J, Tiniakos D, Santos-Laso A, Arbelaiz A, Gawish R, Sampedro A, Fontanellas A, Hijona E, Jimenez-Aguero R, Esterbauer H, Stoiber D, Bujanda L, Banales JM, Knapp S, Sharif O, Mann DA. Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage. Gut 2019, 68(3), 533-546.
• Kayser BD, Lhomme M, Prifti E, Da Cunha C, Marquet F, Chain F, Naas I, Pelloux V, Dao MC, Kontush A, Rizkalla SW, Aron Wisnewsky J, Bermúdez-Humarán LG, Oakley F, Langella P, Clément K, Dugail I. Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity. The Faseb Journal 2019, 33(4), 4741-4754.
• CorreiaMelo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk V, Passos JF. Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice. Aging Cell 2019, 18(1), e12882.
• Abou-Beih S, Masson S, Saunders R, Haugk B, Oakley F, Tiniakos D. Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome. Virchows Archiv 2019, 475, 233–243.
• Chen J, Lobb IT, Morin P, Novo SM, Simpson J, Kennerknecht K, Von Kriegsheim A, Batchelor EE, Oakley F, Stark LA. Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway. Nucleic Acids Research 2018, 46(12), 6188-6205.
• Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Salvador EM, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Molecular Therapy 2017, 25(1), 218-231.
• Wettstein G, Luccarini JM, Poekes L, Faye P, Kupkowski F, Adarbes V, Defrêne E, Estivalet C, Gawronski X, Jantzen I, Philippot A, Tessier J, TuyaaBoustugue P, Oakley F, Mann DA, Leclercq I, Francque S, Konstantinova I, Broqua P, Junien JL. The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. Hepatology Communications 2017, 1(6), 524-537.
• Fearn A, Situmorang GR, Fox C, Oakley F, Howarth R, Wilson CL, Kiosia A, Robson MG, Mann DA, Moles A, Sheerin NS. The NF-kB1 is a key regulator of acute but not chronic renal injury. Cell Death and Disease 2017, 8, e2883.
• Luli S, Di Paolo D, Perri P, Brignole C, Hill SJ, Brown H, Leslie J, Marshall HL, Wright MC, Mann DA, Ponzoni M, Oakley F. A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. Journal of Hepatology 2016, 65(1), 75-83.
• Moles A, Butterworth JA, Sanchez A, Hunter JE, Leslie J, Sellier H, Tiniakos D, Cockell SJ, Mann DA, Oakley F, Perkins ND. A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer. Oncogene 2016, 35(35), 4623-4632.
• Gawish R, Maier B, Lakovits K, Hladik A, Korosec A, Mesteri I, Oakley F, Brain J, Lang I, Knapp S. B-cells and neutrophils promote disease tolerance to murine gram negative sepsis. In: Eighth Congress of The International Federation of Shock Societies. 2016, Tokyo: Lippincott Williams & Wilkins.
• Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS, Moles A. Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Scientific Reports 2016, 6, 20101.
• Hardy T, Oakley F, Anstee QM, Day CP. Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum. Annual Review of Pathology: Mechanisms of Disease 2016, 11, 451-496.
• Richter M, Fairhall EA, Hoffmann SA, Tröbs S, Knöspel F, Probert PM, Oakley F, Stroux A, Wright MC, Zeilinger K. Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system. Toxicology Research 2016, 5(1), 278-290.
• Robinson SM, Mann DA, Manas DM, Oakley F, Mann J, White SA. Response to 'Comment on 'The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome''. British Journal of Cancer 2016, 115(8), e8-e8.
• Vyrla D, Nikolaidis G, Oakley F, Perugorria MJ, Tsichlis PN, Mann DA, Eliopoulos AG. TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury. Journal of Immunology 2016, 196(10), 4298-4310.
• Probert PME, Meyer SK, Alsaeedi F, Axon AA, Fairhall EA, Wallace K, Charles M, Oakley F, Jowsey PA, Blain PG, Wright MC. An expandable donor-free supply of functional hepatocytes for toxicology. Toxicology Research 2015, 4(2), 203-222.
• Oakley F, Mann DA. Chapter 15 - Stellate Cell Depletion Models. In: Stellate Cells in Health and Disease. Elsevier Inc, 2015, pp.251-270.
• Moran-Salvador E, Paoli PP, Smith GR, Page A, Howarth RM, Oakley F, Mann J, Mann D. MeCP2 exerts global control over the myofibroblast transcriptome and reveals new regulators of fibrosis. In: The Liver Meeting 2015: 66th Annual Meeting of the American Association for the Study of Liver Diseases. 2015, San Francisco: John Wiley & Sons, Inc.
• Moles A, Butterworth J, Hunter J, Sanchez A, Mann D, Oakley F, Perkins ND. Mutation of Rela THR505 Enhances Liver Regeneration Following Partial Hepatectomy. In: 50th The International Liver Congress 2015. 2015, Vienna, Austria: Elsevier.
• Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Bagchi-Chakraborty J, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA. NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nature Communications 2015, 6, 6818.
• Luli S, Di Paolo D, Wilson C, Wright MC, Brown H, Ponzoni M, Mann D, Oakley F. Non-invasive fluorescent imaging of liver fibrosis and response to therapy in mice. In: The Liver Meeting 2015: 66th Annual Meeting of the American Association for the Study of Liver Diseases. 2015, San Francisco: John Wiley & Sons, Inc.
• Fox C, Howarth R, Callaghan K, Wood KM, Oakley F, Sheerin N, Moles A. Pepstatin A improves renal fibrosis by impairing UPA lysosomal recycling. In: 52nd ERA-EDTA Congress. 2015, London, UK: Oxford University Press.
• Locatelli L, Paoli PP, Hardy T, Howarth RM, Oakley F, Mann D. Sequence Profiling of miRNAs Reveals mir-150-5p as a Regulator of Transdifferentiation. In: The Liver Meeting 2015: 66th Annual Meeting of the American Association for the Study of Liver Diseases. 2015, San Francisco: John Wiley & Sons, Inc.
• Amer AO, Probert PM, Dunn M, Knight M, Vallance AE, Flecknell PA, Oakley F, Cameron I, White SA, Blain PG, Wright MC. Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation. PLoS ONE 2015, 10(8), e0136173.
• Moles A, Butterworth J, Hunter JE, Sanchez AM, Tiniakos D, Mann D, Oakley F, Perkins ND. Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities. In: 66th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. 2015, San Francisco, California: John Wiley & Sons, Inc.
• Wilson CL, Murphy LB, Leslie J, Kendrick S, French J, Fox CR, Sheerin NS, Fisher A, Robinson JH, Tiniakos DG, Gray DA, Oakley F, Mann DA. Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease. Journal of Hepatology 2015, 63(6), 1421-1428.
• Probert PME, Ebrahimkhani MR, Oakley F, Mann J, Burt AD, Mann DA, Wright MC. A reversible model for periportal fibrosis and a refined alternative to bile duct ligation. Toxicology Research 2014, 3(2), 98-109.
• Luli S, Hill S, Wilson CL, Wright MC, Mann DA, Oakley F. A simple fluorescence based method to non-invasively image liver fibrosis. In: The International Liver Congress 2014: 49th Annual Meeting of the European Association for the Study of the Liver. 2014, London: Elsevier BV.
• Moles A, Murphy L, Wilson CL, Bagchi Chakraborty J, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. Journal of Hepatology 2014, 60(4), 782-791.
• Jurk D, Wilson C, Passos J, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SLF, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature Communications 2014, 5, 4172.
• Skamarauskas JT, Oakley F, Smith FE, Bawn C, Dunn M, Vidler DS, Clemence M, Blain PG, Taylor R, Gamcsik MP, Thelwall PE. Non-invasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker. Hepatology 2014, 59(6), 2321-2330.
• Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3. PLoS One 2014, 9(1), e83391.
• O'Reilly S, Cant R, Ciechomska M, Finnigan J, Oakley F, Hambleton S, van Laar JM. Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-kappa B. Immunology 2014, 143(3), 331-340.
• Probert PM, Chung GW, Cockell SJ, Agius L, Mosesso P, White SA, Oakley F, Brown CD, Wright MC. Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies. Toxicological Sciences 2014, 137(2), 350-370.
• Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, Fisher A, O'Reilly S, van Laar JM, White SA, Perkins ND, Burt AD, Mann DA, Oakley F. Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. Hepatology 2013, 57(2), 817-828.
• Robinson SM, Mann J, Vasilaki A, Mathers J, Burt AD, Oakley F, White SA, Mann DA. Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. Journal of Hepatology 2013, 59(2), 318-326.
• Mann DA, Oakley F. Serotonin paracrine signaling in tissue fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013, 1832(7), 905-910.
• Fullard N, Moles A, O'Reilly S, van Laar JM, Faini D, Diboll J, Reynolds NJ, Mann DA, Reichelt J, Oakley F. The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice. American Journal of Pathology 2013, 182(6), 2109-2120.
• Robinson SM, Mann DA, Manas DM, Oakley F, Mann J, White SA. The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome. British Journal of Cancer 2013, 109(9), 2396-2403.
• Perugorria MJ, Murphy LB, Fullard N, Chakraborty JB, Vyrla D, Wilson CL, Oakley F, Mann J, Mann DA. Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice. Hepatology 2013, 57(3), 1238-1249.
• Southern SL, Collard TJ, Urban BC, Skeen VR, Smartt HJ, Hague A, Oakley F, Townsend PA, Perkins ND, Paraskeva C, Williams AC. BAG-1 interacts with the p50-p50 homodimeric NF-kappa B complex: implications for colorectal carcinogenesis. Oncogene 2012, 31(22), 2761-2772.
• Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J. Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology 2012, 56(3), 1129-1139.
• Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, Oakley F, Burt AD, Wilson CL, Anstee QM, Barter MJ, Masson S, Elsharkawy AM, Mann DA, Mann J. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nature Medicine 2012, 18(9), 1369-U110.
• Pritchett J, Harvey E, Athwal V, Berry A, Rowe C, Oakley F, Moles A, Mann DA, Bobola N, Sharrocks AD, Thomson BJ, Zaitoun AM, Irving WL, Guha IN, Hanley NA, Hanley KP. Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans. Hepatology 2012, 56(3), 1108-1116.
• Fullard N, Wilson CL, Oakley F. Roles of c-Rel signalling in inflammation and disease. International Journal of Biochemistry & Cell Biology 2012, 44(6), 851-860.
• Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamaño JH, Figg N, Foo RS, Mann J, Mann DA, Oakley F. The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis. American Journal of Pathology 2012, 180(3), 929-939.
• Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffre F, Maroteaux L, Mann DA. Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease. Nature Medicine 2011, 17(12), 1668-U189.
• Gieling RG, Elsharkawy AM, Caamano JH, Cowie DE, Wright MC, Ebrahimkhani MR, Burt AD, Mann J, Raychaudhuri P, Liou HC, Oakley F, Mann DA. The c-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation. Hepatology 2010, 51(3), 922-931.
• Elsharkawy AM, Oakley F, Lin F, Packham G, Mann DA, Mann J. The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. Journal of Hepatology 2010, 53(3), 519-527.
• Oakley F, Teoh V, Ching-A-Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA. Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser⁵³⁶ to Promote Myofibroblast Survival and Liver Fibrosis. Gastroenterology 2009, 136(7), 2334-2344.
• Hannivoort RA, Dunning S, Borght SV, Schroyen B, Woudenberg J, Oakley F, Buist-Homan M, van den Heuvel FAJ, Geuken M, Geerts A, Roskams T, Faber KN, Moshage H. Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology 2008, 48(2), 624-634.
• Watson MR, Wallace K, Gieling RG, Manas DM, Jaffray E, Hay RT, Mann DA, Oakley F. NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. Journal of Hepatology 2008, 48(4), 589-597.
• Mann J, Oakley F, Akiboye F, Elsharkawy A, Thorne AW, Mann DA. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death and Differentiation 2007, 14(2), 275-285.
• Ruddell RG, Oakley F, Hussain Z, Yeung I, Bryan-Lluka LJ, Ramm GA, Mann DA. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. American Journal of Pathology 2006, 169(3), 861-876.
• Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut 2006, 55(11), 1606-1616.
• Smith PG, Oakley F, Fernandez M, Mann DA, Lemoine NR, Whitehouse A. Herpesvirus saimiri-based vector biodistribution using noninvasive optical imaging. Gene Therapy 2005, 12(19), 1465-1476.
• Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA. Inhibition of Inhibitor of κB Kinases Stimulates Hepatic Stellate Cell Apoptosis and Accelerated Recovery From Rat Liver Fibrosis. Gastroenterology 2005, 128(1), 108-120.
• Mann DA, Oakley F. NF-kappaB: a signal for cancer. Journal of Hepatology 2005, 42(4), 610-611.
• Oakley F, Mann J, Nailard S, Smart DE, Mungalsingh N, Constandinou C, Ali S, Wilson SJ, Millward-Sadler H, Iredale JP, Mann DA. Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury. American Journal of Pathology 2005, 166(3), 695-708.
• Oakley F, Horn NM, Thomas AL. Histidine-stimulated divalent metal uptake in human erythrocytes and in the erythroleukaemic cell line HEL.92.1.7. Journal of Physiology 2004, 561(2), 525-534.
• Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA. Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1. Journal of Biological Chemistry 2003, 278(27), 24359-24370.
• Oakley F, Trim N, Constandinou CM, Ye W, Gray AM, Frantz G, Hillan K, Kendall T, Benyon RC, Mann DA, Iredale JP. Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis. The American Journal of Pathology 2003, 163(5), 1849-1858.