Staff Profile

Introduction

I am a member of the Respiratory Medicine Research Group 

https://scholar.google.co.uk/citations?user=tee0BA4AAAAJ&hl=en

https://orcid.org/0000-0002-6954-9611

Interests

• Modelling of COVID-19 using human epithelial models
• Injury and remodelling in airways disease
• Integrative pathophysiology in translational research

Awards

Thoracic Society of Australia and New Zealand Victorian Young Investigator Award

European Respiratory Society Long Term Research Fellow

European Respiratory Society Asthma and Allergy Research Award

European Respiratory Society Lung Transplant Research Prize (X2 to my students)

Funding

European Respiratory Society Research Fellow

MRC Project grant

MRC Clinical Fellowship (Supervisor)

MRF

TSB/Innovate UK

Industrial collaboration 

  1.     OUTLINE

     My primary interest is in patho-physiological changes in the human lung as denoted by bronchoalveolar lavage (BAL) and biopsy techniques. My commitment is to patho-physiological studies in translational human research, integrating this into teaching.

  2.     COLLABORATORS

External: Prof. E Haydn Walters, University of Tasmania. Dr Bob Rutherford University of Galway. Dr Des Murphy Cork University, Dr Jacky Smith University of Manchester.

Internal: Prof Jeff Pearson ICaMB, Prof. Mike Griffin (RVI Newcastle), Prof Janet Wilson (Freeman Hospital) Dr Stephen Bourke and Simon Doe, Adult CF Unit RVI Newcastle, Dr Bernard Verdon and Mr Rhys JonesRespiratory researchers in Newcastle: 

  3.     GRANTS (current and major finished ones)

Pilot trial of anti reflux therapy in IPF Type : Project Grant

Provider : British Lung Foundation Amount in EURO : 180,000 Year : 2013-2015.

Aerodigestive injury in IPF and CF. Type : Fellowship.

Provider : MRC/Technology Strategy Board. Amount in EURO : 200,000 Year : 2012-2014

Aspiration injury in bronchiectasis. Type: ERS Fellowship Dr Friel. Provider : ERS

Amount in EURO : 30,000 Year : 2013.

Aspiration injury in bronchiectasis. Type: Fellowship Dr Friel, following and due to previous ERS award

Provider : Irish Health Research Board Amount in EURO : 400,000 Year : 2013-2017

STRATEGIC RESEARCH CENTRE GRANT INOVCF-Innovative non-CFTR Approaches for Cystic Fibrosis Therapy. Co-I. Provider CF Trust Amount in EURO: 910,000 Year: 2014-2018

'Mucus permeating nanoparticulate drug delivery systems' Project Alexander EU FP7. €15.5 million (Co-I with Prof JP Pearson, Newcastle University split €830,000)

Azithromycin therapy  in BOS. Type : Project grant. Provider : MRC Amount in EURO : 600,000 Year : 2006-2010                                                                                                                                                                                                                                                                                                                                       4. PROJECTS

Primary culture to model airway injury in Respiratory Medicine

Aerodigestive biology in Respiratory Medicine

Azithromycin therapy in Bronchiolitis Obliterans Syndrome post lung transplantation, with clinical lead Prof. Paul Corris

Esteem Indicators

Academic activities

h index 53 Google Scholar

Faculty 1000Prime publication:  http://f1000.com/prime/1124482: Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis. Anwar GA, Bourke SC, Afolabi G, Middleton P, Ward C, Rutherford RM. Respir Med. 2008 Oct; 102(10):1494-6

Grants
. Reviewer for Medical Research Council
. Reviewer for National Health and Medical Research Council Australia
. Reviewer for Action Research UK

. Reviewer for Swiss National Science Foundation

Journals
. Reviewer for European Respiratory Journal
. Reviewer for Thorax
. Reviewer for American Thoracic Society Journals
. Reviewer for Respiratory Research (European 'open access)
. Reviewer for European Journal of Allergy and Clinical Immunology

Selected speaking engagements
. Invited speaker: BAL task force meeting (satellite of the European Respiratory Society meeting) 1996
. Invited speaker: BAL task force meeting 1997
. Invited speaker: BAL task force meeting 1998
. Invited speaker: Australian Defense Services and Training Organisation: Response of the lung to injury 1999
. Invited speaker: Determinants and targets in progressive airways disease: Remodelling, fibrosis and angiogenesis Melbourne 2000
. Sentinel presentation Airway remodelling in asthma. British Thoracic Society. Dec 2000.
(Cited in Highlights of the British Thoracic Society Winter Meeting 2000. L Hosking, D Thickett Thorax 2001;56:412–414 412).
. European Respiratory Society Airway epithelial workshop, Paris 2003, Invited participant.
. European Respiratory Society Airway smooth muscle pathogenesis workshop, Gothenburg 2004.
. Invited speaker European Respiratory Society Annual conference Glasgow 2004. Bronchiolitis Obliterans Syndrome, new tools.
. Invited speaker Airway Diseases a shared approach to management York April 2005. Gastric aspiration in lung transplantation.
. Invited speaker, Swedish CF research group, Gothenburg 2005.
. Scientific session chair European Respiratory Society Munich 2006
. Invited speaker International conference on human Pepsin, Nottingham 2006. Gastric aspiration in lung transplantation.
. Invited speaker. Translational studies in airway remodelling. Menzies Institute, University of Tasmania, Feb 2007
. Scientific session chair European Respiratory Society Stockholm 2006
. Invited speaker International conference on Human Pepsin, University of Winscosin USA 2008. Gastric aspiration in lung transplantation.

Current teaching

LEAD: Q1213-CVR8002: Q1213
Respiratory and Sleep Science Masters Modernising scientific healthcare in the NHS [Module lead and teacher]    

CVR8012Respiratory and Sleep Science 2 Module Leader 40%

30CVR8011Respiratory and Sleep Science 1Module Leader 35%

20CVR8002Introduction to Respiratory and Sleep Science Module Leader 45%

10PSC3012 Integrated PhysiologyLecturer 7%

10PSC2016Molecular Physiology and Pathophysiology Lecturer 30%

15BMS2011The Nervous System and Respiratory Diseases Lecturer 15%

Q1213-SPE1015-SPE8101: Q1213- Physiology for Speech and Language 15 credit

Q1213-PGY8005: Q1213- TRANSPLANTATION SCIENCES 20 credit

First Year Medical student Seminar group tutor: Asthma and COPD

Current PhD/MD students: (% supervision split)

Hafez Abedal-Wali Oqlah Al-momani (50%)
Muneef Manea A. Aldhafeeri (50%)
Adil Abdullah A Aldhahrani (50%)
Gemma Louise Crossfield (30%)

Melissa Jane Friel (50%) [Joint PhD Univ of Galway]
Rhys Jones (50%)
Amaran Krishnan (50%)
Shameem Sultanali LADAK (50%)
Therese Mary Frances Small (50%)

Elizabeth Jane Moisey (10%)

James Gray Macfarlane (10%)

• Brennan M, McDonnell MJ, Ward C, Alamer A, Duignan N, Rutherford RM. Bronchiectasis in the Elderly—a Disease That Has Not Gone Away. Current Geriatrics Reports 2020, 9, 19-29.
• Mavin E, Verdon B, Carrie S, Saint-Criq V, Powell J, Kuttruff CA, Ward C, Garnett JP, Miwa S. Real-time measurement of cellular bioenergetics in fully differentiated human nasal epithelial 2 cells grown at air-liquid-interface. American Journal of Physiology-Lung Cellular and Molecular Physiology 2020, 318(6), L1158-L1164.
• Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2020, 202(8), 1133-1145.
• Powell J, Verdon B, Wilson JA, Simpson AJ, Pearson J, Ward C. Establishment of an immortalized human subglottic epithelial cell line. Laryngoscope 2019, 129(11), 2640-2645.
• Tji-JoongGan C, Ward C, Meachery G, Lordan J, Fisher AJ, Corris PA. Long-term effect of azithromycin in bronchiolitis obliterans syndrome. BMJ Open Respiratory Research 2019, 6(1), e000465.
• Dutta P, Funston W, Mossop H, Ryan V, Jones R, Forbes R, Sen S, Pearson J, Griffin SM, Smith J, Ward C, Forrest IA, Simpson AJ. Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis. Thorax 2019, 74(4), 346-353.
• Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA. Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells. Journal of Visualized Experiements 2019, (148), e59815.
• Ward C, Kharaba ZJ. Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux. European Respiratory Journal 2019, 54(4), 1901376.
• Sullivan AF, Hunt EB, Ward C, Lapthorne S, Eustace JA, Fanning LJ, Plant BJ, O'Byrne PM, MacSharry JA, Murphy DM. The presence of Aspergillus fumigatus in asthmatic airways is not clearly related to clinical disease severity. Allergy 2019, 75(5), 1146-1154.
• Ladak SS, Roebuck E, Powell J, Fisher AJ, Ward C, Ali S. The role of miR-200b-3p in modulating TGF-β1 induced injury in human bronchial epithelial cells. Transplantation 2019, 103(11), 2275-2286.
• McDonnell MJ, O'Toole D, Ward C, Pearson JP, Lordan JL, De Soyza A, Loebinger M, Chalmers JD, Laffey JG, Rutherford RM. A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk. Respiratory Medicine 2018, 141, 132-143.
• McDonnell MJ, Ward C, Rutherford RM. Comorbidities and their impact. In: Chalmers JD, Polverino E, Aliberti S, ed. Bronchiectasis (ERS Monograph). Sheffield: European Respiratory Society, 2018, pp.45-61.
• Jolly MK, Ward C, Eapen MS, Myers S, Hallgren O, Levine H, Sohal SS. Epithelial mesenchymal transition (EMT), a spectrum of states: role in lung development, homeostasis and disease. Developmental Dynamics 2018, 247(3), 346-358.
• Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. American Journal of Respiratory and Critical Care Medicine 2018, 198(3), 340-349.
• Ward C, Jones R, Friel M, Hunt E, Murphy D. Pathophysiology in the Lung. In: Morice AH, Dettmar PW, ed. Reflux Aspiration and Lung Disease. Springer International Publishing AG, part of Springer Nature 2018, 2018, pp.55-69.
• Murphy DM, Ward C, Hunt EB, MacSharry J, Pearson JP. Response. Chest 2018, 153(4), 1077-1078.
• Al Momani H, Perry A, Jones R, McDonnell M, Krishnan A, Robertson A, Griffin M, Rutherford R, Brodlie M, Pearson J, Bourke S, Ward C. Risk factors for lung disease progression in children with cystic fibrosis. European Respiratory Journal 2018, 52(4), 1801492.
• Aldhahrani A, Powell J, Ladak S, Ali M, Ali S, Verdon B, Pearson J, Ward C. The Potential Role of Bile Acids in Acquired Laryngotracheal Stenosis. The Laryngoscope 2018, 128(9), 2029-2033.
• Eapen MS, Hansbro PM, McAlinden K, Kim RY, Ward C, Hackett T-L, Walters EH, Sohal SS. Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD). Scientific Reports 2017, 7(1), 13392.
• Sohal SS, Eapen MS, Ward C, Walters EH. Airway inflammation and inhaled corticosteroids in COPD. European Respiratory Journal 2017, 49(6), 1700289.
• Shellman Z, Aldhahrani A, Verdon B, Mather M, Paleri V, Wilson JA, Pearson J, Ward C, Powell J. Bile acids: a potential role in the pathogenesis of pharyngeal malignancy. Clinical Otolaryngology 2017, 42(5), 969-973.
• Ibrahim SH, Turner MJ, Saint-Criq V, Garnett J, Haq IJ, Brodlie M, Ward C, Borgo C, Salvi M, Venerando A, Gray MA. CK2 is a key regulator of SLC₄A2- mediated Cl-/HCO₃- exchange in human airway epithelia. Pflügers Archiv - European Journal of Physiology 2017, 469(9), 1073-1091.
• Aldhahrani A, Verdon B, Ward C, Pearson J. Effects of Bile acids on Human Airway Epithelial Cells; implications for aerodigestive diseases. ERJ Open Research 2017, 3(1), 00107-2016.
• Mahmood M, Ward C, Muller K, Sohal S, Walters EH. Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease. Medical Oncology 2017, 34, 45.
• Sohal SS, Eapen MS, Ward C, Walters EH. Epithelial-mesenchymal transition: A necessary new therapeutic target in chronic obstructive pulmonary disease?. American Journal of Respiratory and Critical Care Medicine 2017, 196(3), 393-394.
• Al-momani H, Perry A, Jones R, Bourke S, Doe S, Perry J, Anderson A, Forrest T, Forrest I, Griffin M, Brodlie M, Pearson J, Ward C. Nontuberculous mycobacteria in gastrostomy fed patients with cystic fibrosis. Scientific Reports 2017, 7, 46546.
• Eapen MS, McAllinden K, Tan D, Weston S, Ward C, Muller HK, Walters EH, Sohal SS. Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD. Respirology 2017, 22(6), 1125-1132.
• Hunt EB, Ward C, Power S, Sullivan A, Pearson J, Lapthorne S, O'Byrne PM, Eustace J, Plant BJ, Maher MM, MacSharry J, Murphy DM. The potential role of aspiration in the asthmatic airway. Chest 2017, 151(6), 1272-1278.
• Mahmood MQ, Reid D, Ward C, Muller HK, Knight DA, Sohal SS, Walters EH. Transforming growth factor (TGF) ß1 and Smad signaling pathways: A likely key to EMT-associated COPD pathogenesis. Respirology 2017, 22(1), 133–140.
• Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. β1-integrin accumulates in cystic fibrosis luminal airway epithelial membranes and decreases sphingosine promoting bacterial infections. Cell Host & Microbe 2017, 21(6), 707-718.e8.
• Mahmood MQ, Walters EH, Shukla SD, Weston S, Muller HK, Ward C, Sohal SS. β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction. Scientific Reports 2017, 7, 10832.
• Hunt E, Lapthorne S, Ward C, Eustace J, Plant B, Murphy D, MacSharry J. A Study To Define The Microbiome Of The Asthmatic Airway. In: American Thoracic Society (ATS) 2016. 2016, San Francisco: American Thoracic Society.
• Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M. Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets. Thorax 2016, 71(3), 284-287.
• McDonnell MJ, Alibert S, Goeminne PC, Restrepo MI, Finch S, Pesci A, Dupont LJ, Fardon TC, Wilson R, Loebinger MR, Skrbic D, Obradovic D, De Soyza A, Ward C, Laffey JG, Rutherford RM, Chalmers JD. Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study. The Lancet Respiratory Medicine 2016, 4(12), 969-979.
• Jones R, Pearson J, Ward C. Functional Dyspepsia. New England Journal of Medicine 2016, 374, 895-896.
• Turner MJ, Saint-Criq V, Patel W, Ibrahim SH, Verdon B, Ward C, Garnett JP, Tarran R, Cann MJ, Gray MA. Hypercapnia Modulates cAMP Signalling and Cystic Fibrosis Transmembrane Conductance Regulator-dependent Anion and Fluid Secretion in Airway Epithelia. Journal of Physiology 2016, 594(6), 1643-1661.
• Garnett J, Kalsi K, Sobotta M, Bearham J, Carr G, Powell J, Brodlie M, Ward C, Tarran R, Baines D. Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H⁺ secretion. Scientific Reports 2016, 6, 37955.
• Bayes HK, Ritchie ND, Ward C, Corris PA, Brodlie M, Evans TJ. IL-22 exacerbates weight loss in a murine model of chronic pulmonary Pseudomonas aeruginosa infection. Journal of Cystic Fibrosis 2016, 15(6), 759–768.
• Soltani A, Walters EH, Reid D, Shukla SD, Nowrin K, Ward C, Muller K, Sohal S. Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD. International Journal of Chronic Obstructive Pulmonary Disease 2016, 11(1), 2359-2367.
• Zeybel GL, Pearson JP, Krishnan A, Bourke SJ, Doe S, Anderson A, Faruqi S, Morice AH, Jones R, McDonnell M, Zeybel M, Dettmar PW, Brodlie M, Ward C. Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation. Journal of Cystic Fibrosis 2016, 16(1), 124-131.
• Al-Momani H, Perry A, Stewart CJ, Jones R, Krishnan A, Robertson AG, Bourke S, Doe S, Cummings SP, Anderson A, Forrest T, Griffin SM, Brodlie M, Pearson J, Ward C. Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients. Scientific Reports 2016, 6, 26985.
• Ladak S, Ward C, Ali S. MiRNA-200b Inhibits Epithelial-Mesenchymal Transition in TGF-b1 Induced Human Bronchial Epithelial Cells. In: 2016 American Transplant Congress (ATC). 2016, Boston: Wiley-Blackwell Publishing, Inc.
• Hunt E, Lapthorne S, Sullivan A, Ward C, Eustace J, Plant B, MacSharry J, Murphy D. Mucosal Cytokines In Asthmatic Bronchoalveolar Lavage (bal) Fluid Reflect Systemic Inflammation And Disease Severity. In: American Thoracic Society (ATS) 2016. 2016, San Francisco: American Thoracic Society.
• McDonnell MJ, Aliberti S, Goeminne PC, Dimakou K, Zucchetti SC, Davidson J, Ward C, Laffey JG, Finch S, Pesci A, Dupont LJ, Fardon TC, Skrbic D, Obradovic D, Cowman S, Loebinger MR, Rutherford RM, De Soyza A, Chalmers JD. Multidimensional severity assessment in bronchiectasis: an analysis of seven European cohorts. Thorax 2016, 71(12), 1110-1118.
• McDonnell MJ, Aliberti S, Goeminne PC, Dimakou K, Zucchetti SC, Davidson J, Ward C, Laffey JG, Finch S, Pesci A, Dupont LJ, Fardon TC, Skrbic D, Obradovic D, Cowman S, Loebinger MR, Rutherford RM, De Soyza A, Chalmers JD. Multidimensional Severity Assessment in Bronchiectasis-An Analysis of 7 European Cohorts. In: ITS Annual Scientific Meeting 2016. 2016, Dublin: Springer UK.
• Cole CC, Carnell SC, Jiwa KJ, Birch JB, Hester KH, Ward CW, Simpson JS, De Soyza ADS. Neutrophil vascular endothelial growth factor (VEGF) as a driving force for angiogenesis in bronchiectasis?. In: British Thoracic Society Winter Meeting 2016. 2016, London: BMJ Group.
• Birch J, Victorelli S, Rahmatika D, Anderson RK, Jiwa K, Moisey E, Ward C, Fisher AJ, De Soyza AJ, Passos JF. Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis. American Journal of Respiratory and Critical Care Medicine 2016, 193(8), 929-932.
• Hunt EB, Sullivan A, Ward C, Power S, Lapthorne S, Pearson J, Eustace J, Plant BJ, Maher MM, MacSharry J, Murphy DM. The Potential Role of Aspiration in the Asthmatic Airway Response. In: ITS Annual Scientific Meeting 2016. 2016, Dublin: Springer UK.
• Ladak SS, Ward C, Ali S. The potential role of microRNAs in lung allograft rejection. Journal of Heart and Lung Transplantation 2016, 35(5), 550-9.
• Powell J, Garnett J, Verdon B, Wilson J, Pearson J, Ward C. A Human in Vitro Model of the Subglottic Airway. Otolaryngology - Head and Neck Surgery 2015, 153(Suppl. 1), P83-P83.
• Corris PA, Ryan VA, Small T, Lordan J, Fisher AJ, Meachery G, Johnson G, Ward C. A randomised controlled trial of azithromycin therapy in Bronchiolitis Obliterans Syndrome (BOS) post lung transplantation . Thorax 2015, 70(5), 442-450.
• Garnett JP, Gray M, Brodlie M, Ward C, Baines DL. Airway epithelial cells secrete bicarbonate in response to acidic by-products of pseudomonas aeruginosa metabolism. In: 29th Annual North American Cystic Fibrosis Conference. 2015, Phoenix, Arizona: Wiley-Blackwell.
• McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Azithromycin Attenuates Release Of Bile Acid-Mediated Neutrophilic And Remodeling Factors From Human Bronchial Epithelial Cells. In: American Thoracic Society International Conference. 2015, Denver, Colorado, USA: American Thoracic Society.
• McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Azithromycin Attenuates Release of Bile Acid-Mediated Neutrophilic and Remodelling Factors from Human Bronchial Epithelial Cells. In: Irish Thoracic Society Annual Scientific Meeting 2015. 2015, Cork, Ireland: Springer London.
• Brodlie M, Aseeri A, Lordan JL, Robertson AGN, McKean MC, Corris PA, Griffin SM, Manning NJ, Pearson JP, Ward C. Bile acid aspiration in people with cystic fibrosis before and after lung transplantation. European Respiratory Journal 2015, 46(6), 1820-1823.
• McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Bile Acids Cause Direct Inflammation and Injury and Worsen Acid Induced Injury in the Pulmonary Epithelium. In: Irish Thoracic Society Annual Scientific Meeting 2015. 2015, Cork, Ireland: Springer.
• McDonnell MJ, O'Toole D, Rutherford R, De Soyza A, Lordan J, Pearson J, Ward C, Laffey JG. Bile Acids Cause Direct Inflammation And Injury And Worsen Acid Induced Injury In The Pulmonary Epithelium. In: American Thoracic Society 2015 International Conference. 2015, Denver, Colorado, USA: American Thoracic Society.
• Hunt EB, Lapthorne S, Ward C, Eustace J, Plant BJ, MacSharry J, Murphy DM. Describing the Microbiome in the Asthmatic Airway. In: Irish Thoracic Society Annual Scientific Meeting 2015. 2015, Cork, Ireland: Springer London.
• Mahmood MQ, Sohal SS, Shukla SD, Ward C, Hardikar A, Noor WD, Muller HK, Knight DA, Walters EH. Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction. International Journal of Chronic Obstructive Pulmonary Disease 2015, 10(1), 1515-1524.
• McDonnell MJ, Ahmed M, Das J, Ward C, Mokoka M, Breen DP, O'Regan A, Gilmartin JJ, Bruzzi J, Rutherford RM. Hiatal hernias are correlated with increased severity of non-cystic fibrosis bronchiectasis. Respirology 2015, 20(5), 749-757.
• Ward C, Uller L. 'To measure is to know' (Lord Kelvin). Respirology 2015, 20(1), 9-10.
• Sohal SS, Soltani A, Reid D, Ward C, Wills KE, Muller HK, Walters EH. A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial-mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study. International Journal of Chronic Obstructive Pulmonary Disease 2014, 9, 533-542.
• Jones RT, Krishnan A, Zeybel GL, Pearson JP, Simpson AJ, Griffin SM, Ward C, Forrest IA. Characterisation of Reflux and Aspiration in Idiopathic Pulmonary Fibrosis; An Integrated Approach. In: British Thoracic Society Winter Meeting 2014. 2014, London: BMJ Publishing Group.
• Sohal SS, Ward C, Walters EH. Importance of epithelial mesenchymal transition (EMT) in COPD and asthma. Thorax 2014, 69(8), 768-768.
• McDonnell MJ, Anwar GA, Rutherford RM, De Soyza A, Worthy S, Corris PA, Lordan JL, Bourke S, Afolabi G, Ward C, Middleton P, Middleton D. Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis. Respiratory Medicine 2014, 108(8), 1127-1133.
• Suwara MI, Vanaudenaerde BM, Verleden SE, Vos R, Green NJ, Ward C, Borthwick LA, Vandermeulen E, Lordan J, Van Raemdonck DE, Corris PA, Verleden GM, Fisher AJ. Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation. Transplant International 2014, 27(8), 857-867.
• Crossfield GL, Krishnan A, Bourke S, Anderson A, Gurney A, Dettmar PW, Brownlee I, Ward C, Pearson JP. Overweight and obesity challenges in the Cystic Fibrosis population - a need for revision in nutritional advice?. In: Nutrition Society Winter Meeting 2013, Diet, gut microbiology and human health. 2014, London, UK: Cambridge University Press.
• Ladak SS, Ali S, Ward C. The potential role of miRNA-200b in the development of Bronchiolitis obliterans syndrome. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing.
• Parikh S, Brownlee IA, Robertson AG, Manning NT, Johnson GE, Brodlie M, Corris PA, Ward C, Pearson JP. Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?. Journal of Heart and Lung Transplantation 2013, 32(4), 418-423.
• Griffin SM, Robertson AGN, Bredenoord AJ, Brownlee IA, Stovold R, Brodlie M, Forrest I, Dark JH, Pearson JP, Ward C. Aspiration and Allograft Injury Secondary to Gastroesophageal Reflux Occur in the Immediate Post-Lung Transplantation Period (Prospective Clinical Trial). Annals of Surgery 2013, 258(5), 705-712.
• Garnett JP, Gray MA, Tarran R, Brodlie M, Ward C, Baker EH, Baines DL. Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. PLoS One 2013, 8(10), e76283.
• Jones R, Krishnan A, Forrest I, Ward C, Pearson J, Simpson J, Immanuel A, Griffin SM. Initial Experience of an Aerodigestive Multidisciplinary Team. In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: John Wiley & Sons Ltd.
• McDonnell MJ, Ward C, Lordan JL, Rutherford RM. Non-cystic fibrosis bronchiectasis. QJM: An International Journal of Medicine 2013, 106(8), 709-715.
• Anwar GA, McDonnell MJ, Worthy SA, Bourke SC, Afolabi G, Lordan J, Corris PA, De Soyza A, Middleton P, Ward C, Rutherford RM. Phenotyping adults with non-cystic fibrosis bronchiectasis: A prospective observational cohort study. Respiratory Medicine 2013, 107(7), 1001-1007.
• Sohal SS, Ward C, Danial W, Wood-Baker R, Walters EH. Recent advances in understanding inflammation and remodeling in the airways in chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 2013, 7(3), 275-288.
• Sohal SS, Ward C, Danial W, Wood-Baker R, Walters EH. Recent advances in understanding inflammation and remodeling in the airways in chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 2013, 7(3), 275-288.
• Borthwick LA, Corris PA, Mahida R, Walker A, Gardner A, Suwara M, Johnson GE, Moisey EJ, Brodlie M, Ward C, Perry JD, de Soyza A, Mann DA, Fisher AJ. TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis. American Journal of Transplantation 2013, 13(3), 621-633.
• Robertson AGN, Krishnan A, Ward C, Pearson JP, Small T, Corris PA, Dark JH, Karat D, Shenfine J, Griffin SM. Anti-reflux surgery in lung transplant recipients: outcomes and effects on quality of life. European Respiratory Journal 2012, 39(3), 691-697.
• Aseeri A, Brodlie M, Lordan J, Corris P, Pearson J, Ward C, Manning N. Bile Acids Are Present in the Lower Airways of People with Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2012, 185(4), 463-463.
• Decalmer S, Stovold R, Houghton LA, Pearson J, Ward C, Kelsall A, Jones H, McGuinness K, Woodcock A, Smith JA. Chronic Cough: Relationship Between Microaspiration, Gastroesophageal Reflux, and Cough Frequency. Chest 2012, 142(4), 958-964.
• Brodlie M, Corris PA, Lordan J, Ward C. Interleukin-17 and Cystic Fibrosis Lung Disease. American Journal of Respiratory and Critical Care Medicine 2012, 185(1), 108-109.
• Gardner A, Fisher AJ, Richter C, Johnson GE, Moisey EJ, Brodlie M, Ward C, Krippner-Heidenreich A, Mann DA, Borthwick LA. The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation. American Journal of Pathology 2012, 180(6), 2293-2308.
• Borthwick LA, Sunny SS, Oliphant V, Perry J, Brodlie M, Johnson GE, Ward C, Gould K, Corris PA, De Soyza A, Fisher AJ. Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway. European Respiratory Journal 2011, 37(5), 1237-1247.
• Brodlie M, Lordan J, Ward C. Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?. Thorax 2011, 66(12), 1096.
• Brodlie M, Lordan JL, Ward C. Ceramide and cystic fibrosis lung disease. American Journal of Respiratory and Critical Care Medicine 2011, 183(1), 133.
• Ward C, Rydell-Tormanen K, Westergren-Thorsson G, Eriksson LT, Walters H. Infection and remodelling: a 21st century model of bronchiectasis?. European Respiratory Journal 2011, 38(4), 758-760.
• Brodlie M, McKean MC, Johnson GE, Anderson AE, Hilkens CM, Fisher AJ, Corris PA, Lordan JL, Ward C. Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease. European Respiratory Journal 2011, 37(6), 1378-1385.
• Wen Y, Reid DW, Zhang D, Ward C, Wood-Baker R, Walters EH. Assessment of airway inflammation using sputum, BAL, and endobronchial biopsies in current and ex-smokers with established COPD. International Journal of Chronic Obstructive Pulmonary Disease 2010, 5, 327-334.
• Brodlie M, McKean MC, Johnson GE, Gray J, Fisher AJ, Corris PA, Lordan JL, Ward C. Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease. American Journal of Respiratory and Critical Care Medicine 2010, 182(3), 369-375.
• Dhar R, Anwar GA, Bourke SC, Doherty L, Middleton P, Ward C, Rutherford RM. Efficacy of nebulised colomycin in patients with non-cystic fibrosis bronchiectasis colonised with Pseudomonas aeruginosa. Thorax 2010, 65(6), 553-553.
• Borthwick LA, McIlroy EI, Gorowiec MR, Brodlie M, Johnson GE, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ. Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair. American Journal of Transplantation 2010, 10(3), 498-509.
• Robertson AGN, Ward C, Small T, Lordan J, Fisher AJ, Bredenoord AJ, Corris PA, Dark J, Pearson JP, Griffin SM. Longitudinal changes in gastro-oesophageal reflux from three months to six months post lung transplantation. In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgeons. 2010, London, UK: John Wiley & Sons Ltd.
• Robertson AGN, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM. Lung Transplantation, Gastroesophageal Reflux, and Fundoplication. Annals of Thoracic Surgery 2010, 89(2), 653-660.
• Murphy DM, Forrest IA, Curran D, Ward C. Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects?. Expert Opinion on Investigational Drugs 2010, 19(3), 401-414.
• Brodlie M, McKean MC, Johnson GE, Perry JD, Nicholson A, Verdon B, Gray MA, Dark JH, Pearson JP, Fisher AJ, Corris PA, Lordan J, Ward C. Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs. Experimental Lung Research 2010, 36(2), 101-110.
• Sohal SS, Reid D, Soltani A, Ward C, Weston S, Muller HK, Wood-Baker R, Walters EH. Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology 2010, 15(6), 930-938.
• Small TM, Ward C, Lordan JL, Fisher AJ, Corris PA, Gibson GJ. Static lung volumes in lung transplant recipients with bronchiolitis obliterans syndrome. In: IRISH JOURNAL OF MEDICAL SCIENCE. 2010, 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND: SPRINGER LONDON LTD.
• Ward C, Ryan V, Pearson J. Susceptibility to Exacerbation in COPD. New England Journal of Medicine 2010, 363(27), 2671-2671.
• Robertson AGN, Shenfine J, Ward C, Pearson JP, Dark JH, Corris PA, Griffin SM. A Call for Standardization of Antireflux Surgery in the Lung Transplantation Population. Transplantation 2009, 87(8), 1112-1114.
• Brodlie M, Eger K, Hilkens CMU, Ward C. Airway epithelial cells as guardians of immune homeostasis?. Thorax 2009, 64(11), 1009.
• Robertson AGN, Ward C, Pearson JP, Bredenoord AJ, Fisher AJ, Lordan J, Corris PA, Dark JH, Griffin SM. Aspiration Secondary to Gastro-Oesophageal Reflux but not Duodenal Reflux Occurs in the Immediate Post Lung Transplantation Period. In: Transplant International: 14th Congress of the European Society for Organ Transplantation. 2009, Paris, France: Wiley-Blackwell Publishing Ltd.
• Forrest I, Ward C, Murphy D, Ryan V, Johnson G, Lordan J, Fisher A, Cawston T, Corris P. Bronchalveolar Lavage Neutrophilia and MMP-9 at 3 Months Post Lung Transplantation May Predict the Development of BOS. In: Journal of Heart and Lung Transplantation: 29th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation. 2009, Paris, France: Elsevier Inc.
• Ward C, Eger K, Diboll J, Jones D, Haniffa MA, Fisher A, Brodlie M, Lordan JL, Corris PA, Hilkens CM. Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells. Thorax 2009, 64(5), 430-435.
• Brodlie M, McKean MC, Johnson GE, Fisher AJ, Corris PA, Lordan JL, Ward C. Ceramide is increased and associated with neutrophilic inflammation in the lower airway epithelium of people with cystic fibrosis. In: Thorax: Winter Meeting of the British Thoracic Society. 2009, London, UK: BMJ Group.
• Borthwick LA, Parker SM, Brougham KA, Johnson GE, Gorowiec MR, Ward C, Lordan JL, Corris PA, Kirby JA, Fisher AJ. Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation. Thorax 2009, 64(9), 770-777.
• Robertson AGN, Ward C, Pearson JP, Small T, Lordan J, Fisher AJ, Bredenoord AJ, Dark J, Griffin SM, Corris PA. Longitudinal changes in gastro-oesophageal reflux from 3 months to 6 months after lung transplantation. Thorax 2009, 64(11), 1005-1007.
• Borthwick LA, McIlroy EI, Brodlle MJ, Ward C, Lordan JL, Kirby JA, Corris PA, Fisher AJ. Pro-inflammatory Cytokines IL-1 beta and TNT alpha, but Not IL-8, Cause Aberrant Lung Epithelial Wound Repair Via TGF-beta 1 Driven Epithelial to Mesenchymal Transition (EMT). In: International Society for Heart and Lung Transplantation: Twenty-Ninth Annual Meeting and Scientific Sessions. 2009, Paris, France: Elsevier Inc.
• Brodlie M, McKean MC, Johnson GE, Fisher AJ, Corris PA, Lordan JL, Ward C. Reticular basement membrane thickening in end-stage cystic fibrosis lung disease. In: Thorax: Winter Meeting of the British Thoracic Society. 2009, London, UK: BMJ Group.
• Robertson AGN, Griffin SM, Murphy DM, Pearson JP, Forrest IA, Dark JH, Corris PA, Ward C. Targeting Allograft Injury and Inflammation in the Management of Post-Lung Transplant Bronchiolitis Obliterans Syndrome. American Journal of Transplantation 2009, 9(6), 1272-1278.
• Stovold R, Forrest I, Murphy D, Johnston G, Lordan J, Fisher A, Dark J, Corris P, Pearson J, Ward C. Temporal Patterns of Lung Pepsin Levels in Allografts Suggest Aspiration Is an Ongoing Injury, Which Can Occur Early Following Lung Transplantation. In: Journal of Heart and Lung Transplantation: 29th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation. 2009, Paris, France: Elsevier Inc.
• Parker SM, Goriwiec MR, Borthwick LA, Johnson G, Ward C, Lordan JL, Corris PA, Saretzki GC, Fisher AJ. Airway epithelial cell senescence in the lung allograft. American Journal of Transplantation 2008, 8(7), 1544-1549.
• Walters EH, Reid D, Soltani A, Ward C. Angiogenesis: A potentially critical part of remodelling in chronic airway diseases?. Pharmacology & Therapeutics 2008, 118(1), 128-137.
• Anderson RL, Hiemstra PS, Ward C, Forrest IA, Murphy D, Proud D, Lordan J, Corris PA, Fisher AJ. Antimicrobial Peptides in Lung Transplant Recipients with Bronchiolitis Obliterans Syndrome. European Respiratory Journal 2008, 32(3), 670-677.
• Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Lordan JL, Ward C. Azithromycin attenuates effects of lipopolysaccharide on lung allograft bronchial epithelial cells. The Journal of Heart and Lung Transplantation 2008, 27(11), 1210-6.
• Murphy DM, Forrest IA, Corris PA, Johnson GE, Jones D, Small T, Fisher AJ, Egan JJ, Cawston TE, Lordan JL, Ward C. Azithromycin attenuates lipopolysaccharide-mediated release of interleukin-8 and GM-CSF from primary bronchial epithelial cells derived from stable lung transplant recipients. In: 28th Annual Meeting of the International Society for Heart and Lung Transplantation. 2008, Boston, MA: Journal of Heart and Lung Transplantation: Elsevier.
• Small TM, Ward C, Yates B, Murphy DM, Forrest IA, Lordan JL, Fisher AF, Dark JH, Corris PA. Azithromycin reverses airflow obstruction in established bronchicilitis obliterans syndrome - A three year follow up. In: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2008, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA: ELSEVIER SCIENCE INC.
• Reid DW, Wen Y, Johns DP, Williams TJ, Ward C, Walters EH. Bronchodilator reversibility, airway eosinophilia and anti-inflammatory effects of inhaled fluticasone in COPD are not related. Respirology 2008, 13(6), 799-809.
• Stovold R, Corris PA, Fisher AJ, Lordan JL, Pearson JP, Ward C. Does pepsin in gastric juice aspirated into the lung allograft stimulate mucus hypersecretion?. In: 28th Annual Meeting of the International Society for Heart and Lung Transplantation. 2008, Boston, MA: Journal of Heart and Lung Transplantation: Elsevier.
• Anwar GA, Bourke SC, Afolabi G, Middleton PG, Ward C, Rutherford RM. Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis. Respiratory Medicine 2008, 102(10), 1494-1496.
• Walters EH, Wood-Baker R, Reid DEC, Ward C. Innate immune activation in neutrophilic asthma. Thorax 2008, 63(1), 88-89.
• Stovold R, Forrest IA, Murphy DM, Johnson GE, Lordan J, Fisher AJ, Corris PA, Pearson JP, Ward C. Longitudinal assessment of pepsin levels in lung allografts suggests aspiration is an ongoing injury, which can occur early following lung transplantation. In: Thorax: Winter Meeting of the British Thoracic Society. 2008, London, UK: BMJ Publishing Group.
• Gorowiec MR, Borthwick LA, Pekalski ML, Lordan J, Corris PA, Ward C, Kirby JA, Saretzki GC, Fisher AJ. Oxidative stress induces epithelial to mesenchymal transition in human lung epithelial cells through transforming groeth factor beta and integrin beta6-dependent mechanism. In: Winter Meeting of the British Thoracic Society. 2008, London, England: BMJ Group.
• McIlroy EI, Borthwick LA, Brougham K, Ward C, Lordan J, Kirby JA, Corris PA, Fisher AJ. Pro-inflammatory cytokines dysregulate lung epithelial wound repair via epithelial to mesenchymal transition. In: Winter Meeting of the British Thoracic Society. 2008, London, England: BMJ Group.
• Robertson AGN, Griffin SM, Ward C, Pearson JP, Bredenoord AJ, Dark JH, Fisher AJ, Lordan J, Corris PA. Qualitative and quantitative assessments of aspiration in the immediate post-lung transplantation period. In: Thorax: Winter Meeting of the British Thoracic Society. 2008, London, UK: BMJ Publishing Group.
• Decalmer S, Stovold R, Jones H, Pearson J, Ward C, Houghton LA, Kelsall A, McGuinness K, Woodcock AA, Smith JA. Relationships between micro-aspiration, gastro-oesophageal reflux and cough in chronic cough subjects. In: British Thoracic Society Winter Meeting. 2008, London: Thorax: BMJ Publishing Group.
• Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Ward C, Lordan JL. Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients. American Journal of Physiology: Lung Cellular and Molecular Physiology 2008, 294(3), L592-L599.
• Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Ward C, Jordan JL. Simvastatin potentially decreases neutrophilic inflammation and remodelling in the transplanted airway. In: 28th Annual Meeting of the International Society for Heart and Lung Transplantation. 2008, Boston, MA: Journal of Heart and Lung Transplantation: Elsevier.
• Brodlie M, McKean MC, Perry J, Nicholson A, Johnson GE, Pearson JP, Fisher A, Corris PA, Lordan JL, Ward C. The culture of primary bronchial epithelial cells from the lungs of people with cystic fibrosis removed at the time of transplantation: a model to study cystic fibrosis lung disease. In: British Thoracic Society Winter Meeting 2008. 2008, London: Thorax: BMJ Publishing Group.
• Borthwick LA, Maloney S, Harrington C, Anderson RL, Ward C, Lordan J, Hiemstra PS, Corris PA, De Soyza A, Fisher AJ. Transforming growth factor beta 1 suppresses secretory leucoprotease inhibitor release in response to infection in lung epithelial cells. In: Thorax: Winter Meeting of the British Thoracic Society. 2008, London, UK: BMJ Publishing Group.
• Borthwick LA, Parker SM, Brougham KA, Gorowiec MR, Ward C, Lordan JL, Kirby JA, Corris PA, Fisher AJ. Tumour necrosis factor-α accentuates transforming growth factor-β driven epithelial to mesenchymal transition (EMT) in airway epithelial cells from lung transplant recipients. In: 28th Annual Meeting of the International Society for Heart and Lung Transplantation. 2008, Boston, MA: Journal of Heart and Lung Transplantation: Elsevier.
• Walters EH, Soltani A, Reid DW, Ward C. Vascular remodelling in asthma. Current Opinion in Allergy and Clinical Immunology 2008, 8(1), 39-43.
• Khor YH, Feltis BN, Reid DW, Ward C, Johns DP, Wood-Baker R, Walters EH. Airway cell and cytokine changes in early asthma deterioration after inhaled corticosteroid reduction. Clinical and Experimental Allergy 2007, 37(8), 1189-1198.
• Mackay LS, Pinnion K, Bolton S, Ward C, Lordan J, Fisher AJ, Foster M, Corris PA. Alveolar septae in severe end-stage emphysema show morphological evidence of dysregulated mesenchymal cell proliferation and loss of microvascularity. In: British Thoracic Society Winter 2007 Meeting. 2007, London: Thorax: BMJ Publishing Group.
• Murphy DM, Forrest IA, Ward C, Corris PA, Johnson GE, Jones D, Fisher AJ, Egan JJ, Cawston TE, Lordan JL. Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts. Thorax 2007, 62(9), 833.
• Feltis BN, Wignarajah D, Reid DW, Ward C, Harding R, Walters EH. Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma. Thorax 2007, 62(4), 314-319.
• Walters EH, Reid DW, Johns DP, Ward C. Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling. European Respiratory Journal 2007, 30(3), 574-588.
• Gorowiec MR, Parker SM, Borthwick LA, Ward C, Lordan J, Saretzki GC, Corris PA, Kirby JA, Fisher AJ. Oxidative stress increases transforming growth factor-beta expression and drives epithelial to mesenchymal transition in human lung epithelial cells. In: Winter Meeting of the British Thoracic Society. 2007, London, England: BMJ Group.
• Stovold R, Forrest IA, Corris PA, Murphy DM, Smith JA, Decalmer S, Johnson GE, Dark JH, Pearson JP, Ward C. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection. American Journal of Respiratory and Critical Care Medicine 2007, 175(12), 1298-303.
• Stovold R, Forrest IA, Corris PA, Murphy DM, Smith JA, Decalmer S, Johnson GE, Dark JH, Pearson JP, Ward C. Pepsin, a biomarker of gastric aspiration in lung allografts: A putative association with rejection. American Journal of Respiratory and Critical Care Medicine 2007, 175(12), 1298-1303.
• Parker SM, Ward C, Johnson G, Black F, Lordan JL, Corris PA, Saretzki GC, Fisher AJ. Stress-induced premature senescence in airway epithelium and accelerated lung allograft aging. Journal of Heart and Lung Transplantation 2007, 26(2), S84-S84.
• Parker SM, Gorowiec MR, Borthwick LA, Lordan JL, Ward C, Corris PA, Saretzki GC. Transforming growth factor beta (TGF beta) induces cellular senescence in primary bronchial epithelial cells: A possible role in airway remodelling. In: Thorax: Winter Meeting of the British Thoracic Society. 2007, London, UK: BMJ Group.
• Hanratty B, Hibbert D, Mair F, May C, Ward C, Corcoran G, Capewell S, Litva A. Doctor's understanding of palliative care. Palliative Medicine 2006, 20(5), 493-497.
• Borthwick L, Nazarowicz M, Ward C, Lordan J, Corris PA, Fisher AJ. Epithelial mesencymal transition occurs in primary airway epithelial cells in response to transforming growth factor-beta and epidermal growth factor. In: Winter Meeting of the British Thoracic Society/British Lung Foundation (BTS/BLF). 2006, London: Thorax: BMJ Publishing Group.
• Stovold R, Forrest IA, Murphy DM, Corris PA, Fisher A, Dark J, Pearson JP, Smith JA, Decalmer S, Ward C. Evidence of increased gastric aspiration in acute lung allograft rejection. In: Winter Meeting of the British Thoracic Society/British Lung Foundation (BTS/BLF). 2006, London: Thorax: BMJ Publishing Group.
• Feltis BN, Wignarajah D, Zheng L, Ward C, Reid D, Harding R, Walters EH. Increased vascular endothelial growth factor and receptors - Relationship to angiogenesis in asthma. American Journal of Respiratory and Critical Care Medicine 2006, 173(11), 1201-1207.
• Nazarowicz M, Borthwick L, Parker S, Ward C, Corris PA, Lordan J, Fisher AJ. Oxidative stress induces epithelial to mesenchymal transition in bronchial epithelial cells: A possible role in airway remodelling. In: Winter Meeting of the British Thoracic Society/British Lung Foundation (BTS/BLF). 2006, London, UK: Thorax: BMJ Publishing Group.
• Parker SM, Johnson G, Ward C, Black F, Lordan J, Corris PA, Saretzki GC, Fisher AJ. Premature senescence of airway epithelial cells: A possible role in airway remodelling after human lung transplantation. In: Winter Meeting of the British Thoracic Society/British Lung Foundation (BTS/BLF). 2006, London: Thorax: BMJ Publishing Group.
• Ward C, Murphy D, Forrest I, Jones D, Pritchard G, Stovold R, Fisher A, Cawston T, Lordan J, Corris P. The phosphodiesterase type IV (PDE IV) inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells derived from lung transplant recipients. In: Journal of Heart and Lung Transplantation: 26th Annual Meeting of the International Society for Heart and Lung Transplantation. 2006, Madrid, Spain: Elsevier Inc.
• Murphy DM, Ward C, Forrest IA, Pritchard G, Jones D, Stovold R, Fisher AJ, Cawston TE, Lordan JL, Corris PA. The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients. The Journal of Heart and Lung Transplantation 2006, 25(12), 1436-1440.
• Borthwick L, Nazarowicz M, Ward C, Lordan J, Corris PA, Fisher AJ. Tumour necrosis factor-alpha accentuates transforming growth factor-beta driven epithelial to mesenchymal transition in lung epithelial cells. In: Winter Meeting of the British Thoracic Society/British Lung Foundation (BTS/BLF). 2006, London: Thorax: BMJ Publishing Group.
• Ward C, De Soyza A, Fisher AJ, Pritchard G, Forrest I, Corris P. A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients. Journal of Heart and Lung Transplantation 2005, 24(5), 533-537.
• Ward C, Walters H. Airway wall remodelling: The influence of corticosteroids. Current Opinion in Allergy and Clinical Immunology 2005, 5(1), 43-48.
• Yates B, Murphy DM, Forrest IA, Ward C, Rutherford RM, Fisher AJ, Lordan JL, Dark JH, Corris PA. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. American Journal of Respiratory and Critical Care Medicine 2005, 172(6), 772-775.
• Reid DW, Walters EH, Johns DP, Ward C, Burns GP, Liakakos P, Williams TJ, Snell GI. Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation. Journal of Heart and Lung Transplantation 2005, 24(4), 489-492.
• Forrest IA, Nicholson L, Platt R, Ward C, Dark JH, Middleton PG, Corris PA. Genetic polymorphisms and bronchiolitis obliterans syndrome post lung transplantation. In: Journal of Heart and Lung Transplantation: The International Society for Heart and Lung Transplantation Twenty-Fifth Anniversary Meeting and Scientific Sessions. 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
• Ward C, Robertson H, Forrest IA, Lordan J, Murphy D, Dark JH, Corris PA, Jones DEJ, Kirby JA. Hypothesis: Epithelial-to-mesenchymal transition is a common cause of chronic allograft failure. In: 20th International Congress of the Transplantion Society. 2005, Vienna, Austria: Transplantation Proceedings, Elsevier.
• Ward C, Reid DW, Orsida BE, Feltis B, Ryan VA, Johns DP, Walters EH. Inter-relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper-reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis. Clinical and Experimental Allergy 2005, 35(12), 1565-1571.
• Zheng L, Orsida B, Whitford H, Levvey B, Ward C, Walters EH, Williams TJ, Snell GI. Longitudinal comparisons of lymphocytes and subtypes between airway wall and bronchoalveolar lavage after human lung transplantation. Transplantation 2005, 80(2), 185-192.
• Ward C, Forrest IA, Brownlee IA, Johnson GE, Murphy DM, Pearson JP, Dark JH, Corris PA. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005, 60(10), 872-874.
• Ward C, Forrest IA, Murphy DM, Johnson GE, Robertson H, Cawston TE, Fisher AJ, Dark JH, Lordan JL, Kirby JA, Corris PA. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 2005, 60(10), 865-871.
• Forrest IA, Murphy DM, Ward C, Jones D, Johnson GE, Archer L, Gould FK, Cawston TE, Lordan JL, Corris PA. Primary airway epithelial cell culture from lung transplant recipients. The European Respiratory Journal 2005, 26(6), 1080-1085.
• Feltis BN, Reid DW, Ward C, Walters EH. BAL eotaxin and IL-5 in asthma, and the effects of inhaled corticosteroid and beta2 agonist. Respirology 2004, 9(4), 507-13.
• Ward C, Headland L, Vest S, Brownlee IA, Forrest IA, Ward TA, Pritchard G, Murphy DM, Pearson JP, Dark J, Corris P. Clinically silent gastric aspiration is common in lung allografts. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Forrest IA, Murphy D, Lordan JL, Pritchard GE, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Corris PA, Ward C. Epithelial to mesenchymal transition in clinically stable lung transplantation. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Forrest IA, Platt RE, Nicholson L, Pritchard G, Murphy D, Ward C, Corris PA, Middleton PG. Genotypic risk factors for the development of the bronchiolitis oblitererans syndrome (BOS) after lung transplantation. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Murphy DM, Forrest IA, Ward C, Pritchard G, Jones D, Egan JJ, Cawston TE, Corris PA, Lordan JL. IL-17 stimulates IL-8 release in primary epithelial cell cultures derived from lung allografts. In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
• Ward C, De Soyza A, Fisher AJ, Pritchard G, Forrest IA, Corris PA. Reticular basement membrane thickening in airways of lung transplant recipients is not affected by inhaled corticosteroids. Clinical and Experimental Allergy 2004, 34(12), 1905-1909.
• Reid DW, Johns DP, Feltis B, Ward C, Walters EH. Exhaled nitric oxide continues to reflect airway hyperresponsiveness and disease activity in inhaled corticosteroid-treated adult asthmatic patients. Respirology 2003, 8(4), 479-486.
• Reid DW, Ward C, Wang N, Zheng L, Bish R, Orsida B, Walters EH. Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo. European Respiratory Journal 2003, 21(6), 994-999.
• Ward C, Camara M, Forrest I, Rutherford R, Pritchard G, Daykin M, Hardman A, De Soyza A, Fisher AJ, Williams P, Corris PA. Preliminary findings of quorum signal molecules in clinically stable lung allograft recipients. Thorax 2003, 58(5), 444-446.
• Strube G, Ward C, Reid D, Walters EH. Revision of BTS guidelines for treatment of asthma [1] (multiple letters). Thorax 2003, 58(3), 280-281.
• Whitford H, Walters EH, Levvey B, Kotsimbos T, Orsida B, Ward C, Pais M, Reid S, Williams T, Snell G. Addition of inhaled corticosteroids to systemic immunosuppression after lung transplantation: a double-blind, placebo-controlled trial [see comment]. Transplantation 2002, 73(11), 1793-1799.
• Ward C, Pais M, Bish R, Reid D, Feltis B, Johns D, Walters EH. Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002, 57(4), 309-316.
• Ward RJ, Ward C, Johns DP, Skoric B, Abramson M, Walters EH. European Community Respiratory Health Survey calibration project of dosimeter driving pressures. European Respiratory Journal 2002, 19(2), 252-256.
• Ward C, Walters EH, Zheng L, Whitford H, Williams TJ, Snell GI. Increased soluble CD14 in bronchoalveolar lavage fluid of stable lung transplant recipients. European Respiratory Journal 2002, 19(3), 472-478.
• Ward C, Reid D, Walters EH. Inhaled corticosteroid dosage in asthma - Reply. Thorax 2002, 57(9), 838.
• Ward C, Whitford H, Snell G, Bao H, Zheng L, Reid D, Williams TJ, Walters EH. Bronchoalveolar lavage macrophage and lymphocyte phenotypes in lung transplant recipients. Journal of Heart and Lung Transplantation 2001, 20(10), 1064-1074.
• Orsida BE, Ward C, Li X, Bish R, Wilson JW, Thien F, Walters EH. Effect of a Long-Acting β₂-Agonist over Three Months on Airway Wall Vascular Remodeling in Asthma. American Journal of Respiratory & Critical Care Medicine 2001, 164(1), 117-121.
• Ward C, Walters EH. Eg-1 positive eosinophils in asthma - Reply. American Journal of Respiratory and Critical Care Medicine 2001, 164(1), 171-172.
• Reid D, Snell G, Ward C, Krishnaswamy R, Ward R, Zheng L, Williams T, Walters H. Iron overload and nitric oxide-derived oxidative stress following lung transplantation. Journal of Heart & Lung Transplantation 2001, 20(8), 840-849.
• Tang C, Ward C, Reid D, Bish R, OByrne MP, Walters EH. Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma. Journal of Allergy & Clinical Immunology 2001, 107(5), 863-870.
• Ward C, Johns DP, Bish R, Pais M, Reid DW, Ingram C, Feltis B, Walters EH. Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma. American Journal of Respiratory and Critical Care Medicine 2001, 164(9), 1718-1721.
• Zheng L, Walters EH, Ward C, Wang N, Orsida B, Whitford H, Williams TJ, Kotsimbos T, Snell GI. Airway neutrophilia in stable and bronchiolitis obliterans syndrome patients following lung transplantation. Thorax 2000, 55(1), 53-59.
• Whitford H, Orsida B, Kotsimbos T, Pais M, Ward C, Zheng L, Williams T, Walters EH, Snell G. Bronchoalveolar lavage cellular profiles in lung transplantation: the effect of inhaled corticosteroids. Annals of Transplantation 2000, 5(3), 31-37.
• Ward C, Thien F, Secombe J, Gollant S, Walters EH. Bronchoalveolar lavage fluid urea as a measure of pulmonary permeability in healthy smokers. European Respiratory Journal 2000, 15(2), 285-90.
• Gabbay E, Walters EH, Orsida B, Whitford H, Ward C, Kotsimbos TC, Snell GI, Williams TJ. Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase. American Journal of Respiratory & Critical Care Medicine 2000, 162(6), 2182-2187.
• Zheng L, Orsida BE, Ward C, Wilson JW, Williams TJ, Walters EH, Snell GI. Airway Vascular Changes in Lung Allograft Recipients. Journal of Heart & Lung Transplantation 1999, 18(3), 231-238.
• Tang C, Rolland JM, Ward C, Li X, Bish R, Thien F, Walters EH. Modulatory effects of alveolar macrophages on CD4+ T-cell IL-5 responses correlate with IL-1beta, IL-6, and IL-12 production. European Respiratory Journal 1999, 14(1), 106-112.
• C. Tang,J. M. Rolland,X. Li,C. Ward,R. Bish,E. H. Walters. Alveolar macrophages from atopic asthmatics, but not atopic nonasthmatics, enhance interleukin-5 production by CD4+ T cells. American Journal of Respiratory & Critical Care Medicine 1998, 157(4 Pt 1), 1120-6.
• C. Tang,J. M. Rolland,C. Ward,F. Thien,X. Li,S. Gollant,E. H. Walters. Differential regulation of allergen-specific T(H2)- but not T(H1)-type responses by alveolar macrophages in atopic asthma. Journal of Allergy & Clinical Immunology 1998, 102(3), 368-75.
• C. Ward,G. I. Snell,L. Zheng,B. Orsida,H. Whitford,T. J. Williams,E. H. Walters. Endobronchial biopsy and bronchoalveolar lavage in stable lung transplant recipients and chronic rejection. American Journal of Respiratory & Critical Care Medicine 1998, 158(1), 84-91.
• C. Ward,G. I. Snell,B. Orsida,L. Zheng,T. J. Williams,E. H. Walters. Airway versus transbronchial biopsy and BAL in lung transplant recipients: different but complementary. European Respiratory Journal 1997, 10(12), 2876-80.
• C. Ward,J. Fenwick,H. Booth,E. H. Walters. Albumin is not suitable as a marker of bronchoalveolar lavage dilution in interstitial lung disease.[see comment]. European Respiratory Journal 1997, 10(9), 2029-33.
• C. Tang,J. M. Rolland,C. Ward,B. Quan,E. H. Walters. Allergen-induced airway reactions in atopic asthmatics correlate with allergen-specific IL-5 response by BAL cells. Respirology 1997, 2(1), 45-55.
• P. Liakakos,G. I. Snell,C. Ward,D. P. Johns,T. L. Bamford,T. J. Williams,E. H. Walters. Bronchial hyperresponsiveness in lung transplant recipients: lack of correlation with airway inflammation. Thorax 1997, 52(6), 551-6.
• C. Tang,J. M. Rolland,C. Ward,B. Quan,E. H. Walters. IL-5 production by bronchoalveolar lavage and peripheral blood mononuclear cells in asthma and atopy.[see comment]. European Respiratory Journal 1997, 10(3), 624-32.
• G. I. Snell,C. Ward,J. W. Wilson,B. Orsida,T. J. Williams,E. H. Walters. Immunopathological changes in the airways of stable lung transplant recipients. Thorax 1997, 52(4), 322-8.
• L. Zheng,C. Ward,G. I. Snell,B. E. Orsida,X. Li,J. W. Wilson,T. J. Williams,E. H. Walters. Scar collagen deposition in the airways of allografts of lung transplant recipients. American Journal of Respiratory & Critical Care Medicine 1997, 155(6), 2072-7.
• E. H. Walters,C. Ward,X. Li. Bronchoalveolar lavage in asthma research. Respirology 1996, 1(4), 233-45.
• I. Richmond,H. Booth,C. Ward,E. H. Walters. Intrasubject variability in airway inflammation in biopsies in mild to moderate stable asthma. American Journal of Respiratory & Critical Care Medicine 1996, 153(3), 899-903.
• C. Tang,I. M. Rolland,C. Ward,R. Bish,F. Thien,E. H. Walters. Seasonal comparison of cytokine profiles in atopic asthmatics and atopic non-asthmatics. American Journal of Respiratory & Critical Care Medicine 1996, 154(6 Pt 1), 1615-22.
• H. Booth,I. Richmond,C. Ward,P. V. Gardiner,R. Harkawat,E. H. Walters. Effect of high dose inhaled fluticasone propionate on airway inflammation in asthma. American Journal of Respiratory & Critical Care Medicine 1995, 152(1), 45-52.
• C. Ward,P. V. Gardiner,H. Booth,E. H. Walters. Intrasubject variability in airway inflammation sampled by bronchoalveolar lavage in stable asthmatics.[see comment]. European Respiratory Journal 1995, 8(11), 1866-71.
• P. V. Gardiner,C. Ward,H. Booth,A. Allison,D. J. Hendrick,E. H. Walters. Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics. American Journal of Respiratory & Critical Care Medicine 1994, 150(4), 1006-11.
• M. Duddridge,C. Ward,D. J. Hendrick,E. H. Walters. Changes in bronchoalveolar lavage inflammatory cells in asthmatic patients treated with high dose inhaled beclomethasone dipropionate. European Respiratory Journal 1993, 6(4), 489-97.
• C. Ward,M. Duddridge,J. Fenwick,P. V. Gardiner,A. Fleetwood,D. J. Hendrick,E. H. Walters. Evaluation of albumin as a reference marker of dilution in bronchoalveolar lavage fluid from asthmatic and control subjects. Thorax 1993, 48(5), 518-22.
• P. Gardiner,C. Ward,A. Allison,T. Ashcroft,W. Simpson,H. Walters,C. Kelly. Pleuropulmonary abnormalities in primary Sjogren's syndrome. Journal of Rheumatology 1993, 20(5), 831-7.
• C. Ward,M. Duddridge,J. Fenwick,S. Williams,P. V. Gardiner,D. J. Hendrick,E. H. Walters. The origin of water and urea sampled at bronchoalveolar lavage in asthmatic and control subjects. American Review of Respiratory Disease 1992, 146(2), 444-7.
• S. C. Stenton,E. N. Court,W. P. Kingston,P. Goadby,C. A. Kelly,M. Duddridge,C. Ward,D. J. Hendrick,E. H. Walters. Platelet-activating factor in bronchoalveolar lavage fluid from asthmatic subjects. European Respiratory Journal 1990, 3(4), 408-13.
• S. C. Stenton,C. Ward,M. Duddridge,A. Harris,J. B. Palmer,D. J. Hendrick,E. H. Walters. The actions of GR32191B, a thromboxane receptor antagonist, on the effects of inhaled PAF on human airways. Clinical & Experimental Allergy 1990, 20(3), 311-7.
• C. Ward,C. A. Kelly,S. C. Stenton,M. Duddridge,D. J. Hendrick,E. H. Walters. The relative contribution of bronchoalveolar macrophages and neutrophils to lucigenin- and luminol-amplified chemiluminescence.[see comment]. European Respiratory Journal 1990, 3(9), 1008-14.
• M. Duddridge,C. A. Kelly,C. Ward,D. J. Hendrick,E. H. Walters. The reversible effect of lignocaine on the stimulated metabolic activity of bronchoalveolar lavage cells. European Respiratory Journal 1990, 3(10), 1166-72.
• C. A. Kelly,S. C. Stenton,C. Ward,G. Bird,D. J. Hendrick,E. H. Walters. Lymphocyte subsets in bronchoalveolar lavage fluid obtained from stable asthmatics, and their correlations with bronchial responsiveness. Clinical & Experimental Allergy 1989, 19(2), 169-75.
• C. Kelly,C. Ward,G. Bird,D. Hendrick,H. Walters. The effect of filtration on absolute and differential cell counts in fluid obtained at bronchoalveolar lavage. Respiratory Medicine 1989, 83(2), 107-10.
• C. A. Kelly,C. Ward,S. C. Stenton,D. J. Hendrick,E. H. Walters. Assessment of pulmonary macrophage and neutrophil function in sequential bronchoalveolar lavage aspirates in sarcoidosis. Thorax 1988, 43(10), 787-91.
• C. Kelly,C. Ward,C. S. Stenton,G. Bird,D. J. Hendrick,E. H. Walters. Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness. Thorax 1988, 43(9), 684-92.
• KELLY C, WARD C, STENTON CS, BIRD G, HENDRICK DJ, WALTERS EH. NUMBER AND ACTIVITY OF INFLAMMATORY CELLS IN BRONCHOALVEOLAR LAVAGE FLUID IN ASTHMA AND THEIR RELATION TO AIRWAY RESPONSIVENESS. THORAX 1988, 43(9), 684-692.
• C. A. Kelly,C. J. Kotre,C. Ward,D. J. Hendrick,E. H. Walters. Anatomical distribution of bronchoalveolar lavage fluid as assessed by digital subtraction radiography. Thorax 1987, 42(8), 624-8.
• S, Pickford PD, Schofield PS, Ward C, Argent BE. Mechanism of the inhibitory effect of trifluoperazine on isoprenaline-evoked amylase secretion from isolated rat parotid glands. Biochem Pharmacol 1986, 35(23), 4121-4.