Staff Profile
Professor Anne Dickinson
Strategic Research Adviser
- Email: [email protected]
- Telephone: 0191 208 6794
- Address: MG262, Academic Haematology
ICM, Ground Floor
Leech Building
The Medical School
Newcastle University
Newcastle upon Tyne
NE2 4HH
I studied Biochemistry/Microbiology at the University of Leeds and was awarded Doctor of Philosophy (Pharmacy) from University of Nottingham on an MRC Studentship.
My first academic post was a Post Doctoral Research Associate in the German Cancer Research Centre, Heidelberg. I returned to the UK to a Research Associate role in the department of Haematology in Newcastle University and have
remained in the North East ever since. My early career included roles as a Grade B Clinical Scientist in Haematology and a Lecturer in Marrow Transplant Biology, specialising in the pathogenesis of Graft versus Host Disease.
I went on to become a Senior Lecturer whilst Head of the Tyneside Leukaemia Research Laboratories and became Health Professions Council registered as a Clinical Scientist. For several years I continued my research activity on
transplantation and graft versus host disease which culminated in a Professorship in 2002. During this time I developed Skimune® Technology, which has been used as a predictive assay for GvHD in Newcastle as part of a clinical protocol for
treatment of haematological disorders. I founded my spin-out Company Alcyomics Ltd in 2007, where I developed Skimune to test drugs for allo-immune responses (i.e. transplant rejection) but also for predicting contact sensitivity and allergic
reactions with development of novel IP.
I am also Director of Newcastle Cellular Therapies Facility. In partnership between Newcastle University and the Newcastle upon Tyne Hospitals NHS Foundation Trust, this is one of the largest facilities in Europe, designed specifically for the production of cellular therapies such as Autologous tolerogenic dendritic cells for rheumatoid arthritis and Limbal stem cells for limbal stem cell deficiency.
Google Scholar: Click here.
- Reis M, McDonald D, Nicholson L, Godthardt K, Knobel S, Dickinson AM, Filby A, Wang X-N. Global phenotypic characterisation of human platelet lysate expanded MSCs by high-throughput flow cytometry. Scientific Reports 2018, 8(1), 3907.
- Dickinson A, Nong Wang X, Ahmed S. An In Vitro Human Skin Test for Assessing Adverse Immune Reactions and Sensitization Potential. In: Alternatives for Dermal Toxicity Testing. Springer International Publishing, 2017, pp.437-448.
- Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM. An in vitro human skin test for assessing sensitization potential. Journal of Applied Toxicology 2016, 36(5), 669-684.
- Norden J, Pearce K, Irving J, Collin M, Wang X, Wolff D, Kolb HJ, Socie G, Kuzmina Z, Greinix H, Holler E, Rocha V, Gluckman E, Hromadnikova I, Dickinson AM. The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation. International Journal of Immunogenetics 2018, 45(5), 247-256.
- Crossland RE, Norden J, Juric MK, Green K, Pearce KF, Lendrem C, Greinix HT, Dickinson AM. Expression of Serum microRNAs is Altered During Acute Graft-versus-Host Disease. Frontiers in Immunology 2017, 8, 308.
- Gam R, Shah P, Crossland RE, Norden J, Dickinson AM, Dressel R. Genetic Association of Hematopoietic Stem Cell Transplantation Outcome beyond Histocompatibility Genes. Frontiers in Immunology 2017, 8, 380.
- Mavin E, Nicholson L, Amed RS, Gao F, Dickinson A, Wang Xiao-nong. Human regulatory T cells mediate transcriptional modulation of dendritic cell function. The Journal of Immunology 2017, 198(1), 138-146.
- Ahmed SS, Wang XN, Norden J, Pearce K, El-Gezawy E, Atarod S, Hromadnikova I, Collin M, Holler E, Dickinson AM. Identification and validation of biomarkers associated with acute and chronic graft versus host disease [Corrigendum]. Bone Marrow Transplantation 2016, 51(6), 890.
- Atarod S, Ahmed MA, Lendrem C, Pearce KP, Cope W, Norden J, Wang X, Collin M, Dickinson AM. MiR-146a and miR-155 expression levels in acute graft-versus-host disease incidence. Frontiers in Immunology (Alloimmunity and Transplantation) 2016, 7, 56.
- Jalapothu D, Boieri M, Crossland RE, Shah P, Butt IA, Norden J, Dressel R, Dickinson AM, Inngjerdingen M. Tissue-specific expression Patterns of Microrna during acute graft-versus-host Disease in the rat. Frontiers in Immunology 2016, 7, 361.
- Atarod S, Pearce K, Norden J, Lendrem C, Crossland R, Wang X, Sviland L, Janin A, Collin M, Dickinson A. Differential microRNA expressions in cutaneous acute graft-versus-host disease. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT). 2015, Istanbul, Turkey.
- Atarod S, Turner B, Pearce KF, Ahmed SS, Norden J, Bogunia-Kubik K, Wang XN, Collin M, Dickinson AM. Elevated level of HSPA1L mRNA correlates with graft-versus-host disease. Transplant Immunology 2015, 32(3), 188-194.
- Ahmed SS, Wang XN, Norden J, Pearce K, El-Gezawy E, Atarod S, Hromadnikova I, Collin M, Holler E, Dickinson AM. Identification and validation of biomarkers associated with acute and chronic graft versus host disease. Bone Marrow Transplantation 2015, 50(12), 1563-1571.
- Gam R, Norden J, Crossland R, Pearce K, Dickinson A. IRAK1 and miR-146a for predicting the outcome of allogeneic haematopoietic stem cell transplantation. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey.
- Gam R, Norden J, Crossland R, Pearce K, Dickinson AM, Univ Newcastle Upon Tyne. IRAK1 and miR-146a for predicting the outcome of allogeneic haematopoietic stem cell transplantation. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey: Nature Publishing Group.
- Gam R, Norden J, Crossland R, Pearce K, Holler E, Dressel R, Dickinson A. MICA genotype, serum and expression level effects on the outcome of HSCT. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey.
- Gam R, Norden J, Crossland R, Pearce K, Holler E, Dressel R, Dickinson AM, Framework CellEurope Project, Professor Anne Dickinson Univ Newc. MICA genotype, serum and expression level effects on the outcome of HSCT. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey: Nature Publishing Group.
- Atarod S, Smith H, Dickinson A, Wang X. MicroRNA levels quantified in whole blood varies from PBMCs. F1000Research 2015, 3, 183.
- Crossland RE, Norden J, Bibby L, Collin M, Dickinson A. Serum MicroRNAs MiR-146a, MiR-199, MiR-93*and MiR-423 as Biomarkers for Graft Versus Host Disease. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey: Nature Publishing Group.
- Crossland RE, Norden J, Collin M, Dickinson A. Urinary MicroRNA Expression is Associated with Incidence and Severity of Graft Versus Host Disease. In: 41st Annual Meeting of the European Society for Blood and Marrow Transplantation. 2015, Istanbul, Turkey: Nature Publishing Group.
- Crossland RE, Norden J, Bibby L, Davis J, Dickinson AM. Validation of Isolation Methodology and Endogenous Control Selection for qRT-PCR Assessment of Microrna Expression in Serum and Urine Exosomes. In: 56th ASH Annual Meeting and Exposition. 2014, San Francisco, CA, USA: American Society of Hematology.
- Atarod S, Dickinson AM. MicroRNAs: the missing link in the biology of graft-versus-host disease?. FRONTIERS IN IMMUNOLOGY 2013, 4.
- Mavin E, Ahmed SS, O'Boyle G, Turner B, Douglass S, Collin M, Ali S, Dickinson A, Wang X-N. Regulatory T Cells Inhibit CD8+ T-Cell Tissue Invasion in Human Skin Graft-Versus-Host Reactions. Transplantation 2012, 94(5), 456-464.
- Ruffin N, Osorio LM, Wang XN, Jackson G, Collin MP, Ahmed SS, Ekre H, Chiodi F, Dickinson AM. Association of Epithelial Fas Up-regulation with Cell Damage in a Human Graft-versus-Host- Disease Model. 2011.
- Ruffin N, Ahmed SS, Osorio LM, Wang XN, Jackson GH, Collin MP, Ekre HP, Chiodi F, Dickinson AM. The Involvement of Epithelial Fas in a Human Model of Graft Versus Host Disease. Transplantation 2011, 91(9), 946-951.
- Dickinson AM, Greinix H. Biomarkers in acute and chronic GvHD. In: Greinix, H, ed. Graft-versus-Host-Disease. Bremen: UNI-MED Verlag AG, 2008, pp.18-31.
- Haniffa MA, Wang XN, Holtick U, Rae M, Isaacs JD, Dickinson AM, Hilkens CM, Collin MP. Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells. Journal of Immunology 2007, 179(3), 1595-1604.
- Holtick U, Marshall SP, Hilkens CMU, Wang XN, Dickinson XN. Immature dendritic cells downregulate graft versus host reactions in the human skin explant model after co-culture with in vitro PUVA treated lymphocytes. Biology of Blood and Marrow Transplantation 2007, 13(2), 109-109.
- Wang XN, Dickinson AM. The 6th Annual Meeting of the UK Cord Blood and Adult Stem Cell Group. Expert Opinion on Biological Therapy 2006, 6(4), 417-421.
- Wang XN, Skinner R, Jackson GH, Proctor SJ, Dickinson AM. Role of T cell frequency analysis in predicting acute graft- versus-host disease in HLA matched sibling bone marrow transplantation. Bone Marrow Transplantation 1999, 23(Supplement 1), S97-S97.
- A. Crossley, J. E. Calvert, P. R. A. Taylor and A. M. Dickinson. A comparison of monoclonal antibody immobilization of platelet antigen (MAIPA) and immunobead methods for detection of GPIIb/IIIa antiplatelet antibodies in immune thrombocytopenic purpura. Transfusion Medicine 1997, 7, 127-134.
- Wang XN, Dickinson AM, Chapman C, Cavanagh G, Dunn J, Proctor SJ. Frequency analysis of allo-reactive helper T-lymphocyte precursors (HTLp) and cytotoxic T lymphocyte precursors (CTLp) using a combined single limiting dilution assay - Correlation with mixed lymphocyte responses. British Journal of Haematology 1996, 93, 144-144.
- Wang XN, Proctor SJ, Dickinson AM. Frequency analysis of recipient-reactive helper and cytotoxic T lymphocyte precursors using a combined single limiting dilution assay. Transplant Immunology 1996, 4(3), 247-251.
- Dickinson AM, Wang XN, Dunn JL, Taylor PRA, Sviland L, Proctor SJ. Predicting graft-versus-host disease in HLA-identical bone marrow transplants: Correlation between a skin explant model and T-cell frequency analysis. British Journal of Haematology 1996, 93(Suppl. 1), 145-145.